Diabetic Nephropathy Progression Not Driven by Ethnicity

Diabetic Nephropathy Progression Not Driven by Ethnicity

In a study, South-Asian and white European diabetics showed similar declines in eGFR over five years.

THC Locks May Offer Edge to Dialysis Patients

In a small study, taurolidine-heparin-citrate locks improved bacteremia-free catheter survival versus heparin-only locks.

AKI Risk Raised with Prophylactic Regimen

Increased rate of acute kidney injury observed with the use of gentamicin plus flucloxacillin after orthopedic surgery.

Dialysis Patients Struggle to Restrict Dietary Phosphorus

Dialysis Patients Struggle to Restrict Dietary Phosphorus

The increasing popularity of processed convenience foods could be a factor.

Renal Denervation Effective Despite Extra Renal Arteries

Researchers observe good blood-pressure lowering at six months.

Algorithm Predicts Transfusion Risk in Dialysis Patients

It uses data commonly available in electronic health records.

Radiologic Insertion of Tenckhoff Catheters Offers Benefits

Peritoneal dialysis patients can undergo the procedure on an outpatient basis.

Medications Found to Relieve CKD-Related Itching

Medications Found to Relieve CKD-Related Itching

Patients experience relief with the use of gabapentin and pregabalin.

Vitamin D Deficient Tx Patients Benefit from Oral Cholecalciferol

Plasma vitamin D levels increased to greater than 50 nmol/L in 80% of patients.

Oral Symptoms Common in Hemodialysis Patients

Patients report dry mouth sensation and difficulties swallowing.

Transplant Failure Portends Higher Mortality Risk

PARIS—Patients who have lost their graft have had renal failure longer and are likely to have more comorbidities.

Vasculitis Patients Have Poor Grasp of Treatment Effects

PARIS—Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have substantial knowledge deficits about potential treatment-related adverse effects, according to data from a British survey.

Daily Fluid Intake Found To Have No Effect on Mortality

PARIS—New data from a population-based cohort study appear to challenge the belief that survival is linked to daily fluid intake.

Hyperphosphatemia Linked to Diuretic Use

PARIS—Diuretics may raise phosphate levels and increase the likelihood of hyperphosphatemia in patients with chronic kidney disease.

High Uric Acid Raises CKD Risk, Study Finds

PARIS—High levels of uric acid are associated with an increased risk of chronic kidney disease (CKD), especially among hypertensive individuals.

Statins Have Mixed Effects in CKD Patients

PARIS—Statin medications appear to have different effects on patients with chronic kidney disease (CKD) depending on their disease stage, researchers reported.

Diabetic Renal Disease Boosts Mortality Risk after Failed Tx

PARIS—British investigators have reported a link between diabetes as primary renal disease (PRD) and survival after transplant failure.

Arterial Stiffness in CKD Patients Tied to Periodontal Health

PARIS—New data show that the severity of periodontitis is associated with arterial stiffness in patients with worsening chronic kidney disease (CKD).

Raising Lanthanum Dose Cuts Phosphorus Levels

PARIS—Raising the dose of the calcium-free phosphate binder lanthanum carbonate from a lower conventionally used dose of 2,250 or less to 3,000 mg/day may reduce phosphorus levels in patients with chronic kidney disease (CKD) and hyperphosphatemia.

Clinical Decision Tool Helps Cut RRT Referral Time

PARIS—Primary care physicians who use a clinical decision support system (CDSS) may be able to avoid late referrals for renal replacement therapy (RRT), researchers reported at the 49th Congress of the European Renal Association-European Dialysis and Transplant Association.

Mortality Linked to Short-Term Change in Kidney Function

PARIS—Short-term changes in estimated glomerular filtration rate (GFR) that exceed 25% are associated with an increased risk of death in patients with or without chronic kidney disease (CKD), British investigators reported at the 49th Congress of the European Renal Association-European Dialysis and Transplant Association.

Sexual Dysfunction is Common in Women on Hemodialysis

PARIS—Sexual dysfunction is highly prevalent in sexually active women with end-stage renal disease requiring hemodialysis (HD), according to data presented at the 49th Congress of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA).

Similar Survival Rates for Hemodiafiltration and Hemodialysis

PRAGUE—End-stage renal disease patients on post-dilution online hemodiafiltration (HDF) or high-flux hemodialysis (HD) have the same overall survival and non-fatal cardiovascular (CV) event rates, new findings show.

Survival Better with HD than PD in CHF Patients

PRAGUE—For patients with congestive heart failure (CHF) who initiate maintenance dialysis, those starting on peritoneal dialysis (PD) have a significantly greater death risk than those starting on hemodialysis (HD), according to a French study.

PP Declines Predict Worse HD Patient Survival

PP Declines Predict Worse HD Patient Survival

PRAGUE—Decreases in pulse pressure (PP), and to a lesser extent increases, predict worse survival in the first year for patients new to hemodialysis (HD), new findings suggest.

LDL Lowering Fails to Slow Renal Disease Progression

PRAGUE—Lowering LDL cholesterol (LDL) can prevent or even reverse atherosclerosis, but it does not do the same for the progression of chronic kidney disease (CKD).

HDL from CDK Patients Loses Vasoprotective Effects

HDL from CDK Patients Loses Vasoprotective Effects

PRAGUE—HDL cholesterol (HDL) in patients with chronic kidney disease (CKD) loses its protective effect on vascular endothelium, new findings suggest. Rather than supporting the beneficial functions of the endothelium, it appears to become pro-inflammatory and inhibit them.

NP-Based Program Helps Control CKD Cardiac Risk Factors

PRAGUE—A multifactorial intervention using a polydrug and lifestyle treatment strategy with nurse practitioner (NP) support can improve management of some cardiovascular (CV) risk factors and reduced the number of physician visits by patients with chronic kidney disease (CKD).

Paricalcitol Superior for Lowering iPTH

The drug was more likely than cinacalcet to achieve a 50 percent or greater decrease in iPTH from baseline.

Hyponatremia May Predict Contrast-Induced Nephropathy

PRAGUE—Transient hyponatremia may precede development of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography, according to investigators.

Study: PD Patients Receive Kidney Transplants Sooner

PRAGUE—End-stage renal disease patients who start on peritoneal dialysis (PD) rather than hemodialysis (HD) spend less time on a renal transplant waiting list before getting a kidney, new findings suggest.

Post-Transplantation Anemia Risk Factors Identified

PRAGUE—Renal transplant recipients who have anemia three months after receiving a kidney are more likely to have anemia more than six months post-transplant, according to researchers.

BP Meds at Bedtime Reduce CVD Risk

BP Meds at Bedtime Reduce CVD Risk

PRAGUE—Taking antihypertensive medications at bedtime significantly reduces cardiovascular disease (CVD) risk compared with ingesting the drugs upon awakening, according to researchers.

No Higher Death Risk with a Later Dialysis Start

PRAGUE—Early referral patients who start dialysis with an estimated glomerular filtration rate (eGFR) below 6 mL/min/1.73 m2 are not at increased risk of death compared with those who start dialysis at an eGFR above 6, a study showed.

Short-Course Rituximab Produces Long-Term Remissions of ANCA Vasculitis

PRAGUE—A single four-week course of rituximab was as effective as 18 months of standard therapy with daily oral cyclophosphamide (CyP) and azathioprine (AZA) for induction and maintenance of remission in patients with severe anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). For either treatment, the number, rate, and severity of adverse events did not differ.

New Findings Confirm Bardoxolone's Efficacy

PRAGUE—Therapy with bardoxolone, an oral antioxidant inflammation modulator, is associated with improved kidney function out to one year in patients with advanced chronic kidney disease (CKD) and type 2 diabetes, according to investigators.

Early Dialysis Start Not Advantageous

Early Dialysis Start Not Advantageous

MUNICH, GERMANY—Planned early initiation of dialysis does not improve survival or clinical outcomes among patients with end-stage renal disease, study findings show.

Gout Drug Has Cardiac Benefit

MUNICH, GERMANY—Allopurinol, a drug long used to treat gout, can cause regression of left ventricular hypertrophy (LVH) and improvement of endothelial dysfunction in CKD patients, a study found.

Sexual Dysfunction Very Common in CKD Patients

MUNICH, GERMANY—Sexual dysfunction is highly prevalent in men and women with CKD, data show.

UTI Pathogens Differ in Renal Transplant Patients

MUNICH, GERMANY—Urinary tract infections (UTIs) caused by non-coliform bacteria are significantly more common among renal transplant patients compared with the general population, according to a British study.

Statins Protect Kidneys In Cardiac Surgery Patients

MUNICH, GERMANY—Statins have a protective effect on renal function after cardiac surgery, according to Italian researchers.

CKD-Related Anemia Occurs Earlier in Women than Men

MUNICH, GERMANY—Among individuals with CKD, anemia occurs earlier in women than men, French researchers reported at the European Renal Association-European Dialysis and Transplant Association 2010 Congress.

Increased Hypertension Risk Found in Live Kidney Donors

MUNICH, GERMANY—Live kidney donors may experience an increase in blood pressure following nephrectomy, new data suggest.

Statin May Benefit Diabetic HD Patients with High Cholesterol

MUNICH, GERMANY—Atorvastatin may benefit hemodialysis (HD) patients with type 2 diabetes and high LDL cholesterol levels, a researcher reported at the the European Renal Association-European Dialysis and Transplant Association 2010 Congress.

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