Diabetic Nephropathy

Glycemic Control Intensity Does Not Influence ESRD, Mortality

Glycemic Control Intensity Does Not Influence ESRD, Mortality

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End-stage renal disease developed in similar proportions of diabetics regardless of whether they had intensive or standard glycemic control.

Biomarkers Predict Rapid Renal Decline in Type 2 Diabetes

Biomarkers Predict Rapid Renal Decline in Type 2 Diabetes

Biomarkers apoA4, CD5L, C1QB, and IBP3 may improve the prediction of rapid decline in renal function independently of recognized clinical risk factors in T2DM.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

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Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

Low Tryptophan May Signal Diabetic Nephropathy

Low Tryptophan May Signal Diabetic Nephropathy

There was a significant association for Trp with the event of rapid decline in eGFR.

sRAGE May Increase Risk of Diabetic Nephropathy

sRAGE May Increase Risk of Diabetic Nephropathy

Higher levels of sRAGE were significantly associated with incidence of DN after adjustment for duration of diabetes.

Children With Diabetic Ketoacidosis at High Risk of AKI

Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

Increased Use of DPP-4, SGLT-2 Inhibitors for Diabetic Nephropathy

Increased Use of DPP-4, SGLT-2 Inhibitors for Diabetic Nephropathy

DPP-4 inhibitors use was used in 54% of treatment visits by the last quarter of 2014; ACEIs and ARBs were prescribed in the majority of treatment visits with peaks above 90%.

Valsartan Reduces Microalbuminuria in IGT Patients

Valsartan Reduces Microalbuminuria in IGT Patients

Valsartan reduced the incidence of microalbuminuria in IGT without increasing the incidence of hyperkalemia or renal dysfunction compared with placebo.

T2DM Microvascular Complications Linked to Periodontitis Severity

T2DM Microvascular Complications Linked to Periodontitis Severity

Poor glycemic control linked to increased prevalence and severity of periodontitis.

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

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Use of the glucagon-like peptide-1 receptor agonist lowered 24-hour urinary albumin excretion rate by 32% over 12 weeks versus placebo.

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Findings in large cohort of patients with diabetes over 4 years of follow-up.

Advanced Glycation End-Products Predict Renal Function Decline

Advanced Glycation End-Products Predict Renal Function Decline

AGEs improve RFL prediction in American-Indians with type 2 diabetes.

Diabetic Kidney Disease Rates in US Hold Steady

Diabetic Kidney Disease Rates in US Hold Steady

No change in overall prevalence from 1988 to 2014; decrease in albuminuria, increase in reduced eGFR.

Slower Kidney Disease Progression Observed With Empagliflozin Use

Slower Kidney Disease Progression Observed With Empagliflozin Use

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Incident or worsening nephropathy was observed in 12.7% of patients receiving empagliflozin compared with 18.8% of those receiving placebo.

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Length of time spent in remission inversely related to risk of microvascular disease.

Kidney Function Decline Tied to CV Events in Diabetics

Kidney Function Decline Tied to CV Events in Diabetics

Renal function decline is independent factor for cardiovascular risk in patients with type 2 diabetes.

Study: Diabetic Nephropathy Underdiagnosed

Study: Diabetic Nephropathy Underdiagnosed

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Diabetic nephropathy lesions may develop prior to the onset of clinical findings.

Acthar Gel May Be an Option for Nephrotic Syndrome

Acthar Gel May Be an Option for Nephrotic Syndrome

Athcar gel may be a treatment option for patients with treatment-resistant nephrotic syndrome.

Diabetes, Diabetic Nephropathy Increased in Children

Diabetes, Diabetic Nephropathy Increased in Children

Increase in prevalence from 2002-2013, with highest prevalence among those aged 12 to less than 18 years.

Patiromer Benefits High-Risk Hyperkalemic Patients

Patiromer Benefits High-Risk Hyperkalemic Patients

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The medication significantly decreased potassium levels over 52 weeks in patients with resistant hypertension and diabetic kidney disease.

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Higher urinary potassium excretion, not sodium excretion, tied to lower risk of primary end point.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Vascular Lesions in Renal Biopsy Specimens Predict CV Events

Vascular Lesions in Renal Biopsy Specimens Predict CV Events

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Significant association found in patients with diabetic nephropathy.

Adding Finerenone Improves Albuminuria in Diabetic Nephropathy

Adding Finerenone Improves Albuminuria in Diabetic Nephropathy

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Hyperkalemia occurred in just 1.8% of patients taking finerenone 7.5 to 20 mg daily.

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric chronic kidney disease was linked to increases in all-cause and cardiovascular mortality, but not albuminuria or end-stage renal disease.

Poorly Controlled Diabetes May Increase Dementia

Poorly Controlled Diabetes May Increase Dementia

Older patients with more diabetes complications have greater cognitive decline, study finds.

Diabetic Kidney Disease Linked to High Uric Acid

Diabetic Kidney Disease Linked to High Uric Acid

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Increased uric acid levels were correlated with decreased HbA1c and increased prevalence of diabetic kidney disease, study finds.

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

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Intense glycemic control was significantly linked to higher risks of cardiovascular and all-cause mortality

Women with Type 1 Diabetes Fare Worse Than Men

Women with Type 1 Diabetes Fare Worse Than Men

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Among the increased risks, women with the disease had an 86% higher chance of dying from cardiovascular disease than men.

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