Diabetic Nephropathy

ESRD More Likely than Death for Patients with Diabetic Nephropathy

Jody A. Charnow December 07, 2011

Patients with type 2 diabetic nephropathy are more likely to progress to end-stage renal disease (ESRD) than die, according to investigators.

Podocytes May Need Insulin to Maintain Kidney Function

Delicia Honen Yard November 15, 2010

Podocytes demonstrate a strong reliance on insulin to function properly, according to a study published in Cell Metabolism (2010;12:329-340).

UACR Varies by Season in Diabetic Nephropathy

Daniel M. Keller, PhD November 15, 2010

Researchers have found a seasonal variation in urinary albumin-to-creatinine ratio (UACR) in Japanese patients with type 2 diabetes and early nephropathy, with the highest values in winter and the lowest in summer.

Morning Urine Test Better For Renal Risk Assessment

Delicia Honen Yard September 24, 2010

The albumin:creatinine ratio in the first urine excreted in the morning is better than 24-hour urinary albumin excretion in determining the risk for renal events in patients with type 2 diabetes and nephropathy, data show.

Vitamin B Could Have a Down Side in Patients with Diabetic Nephropathy

Delicia Honen Yard May 14, 2010

Patients with diabetic nephropathy should avoid taking high doses of B vitamins to lower homocysteine levels.

New Biomarkers of Diabetic Nephropathy

Susanne B. Nicholas, MD, PhD October 22, 2009

Cell adhesion molecules may be potential targets for therapeutic intervention to delay CKD progression.

Megadosage Candesartan Beneficial

Jody A. Charnow February 18, 2009

Renal disease patients who have persistent proteinuria despite treatment with the highest approved dosage of the angiotensin receptor blocker candesartan may benefit from higher dosages, a Canadian study finds.

Predictors of Cardiac Events After Renal Transplantation

Jody A. Charnow November 01, 2008

Diabetic nephropathy and CVD prior to renal transplantation are the most important predictors of post-transplant cardiovascular events, researchers in The Netherlands conclude.

U.K. Team: GFR Estimates Important

Jill Stein September 01, 2008

SAN FRANCISCO—British researchers have endorsed U.S. guidelines stating that screening diabetic patients for renal disease should involve estimated glomerular filtration rate (eGFR) in addition to testing for albuminuria.

Renoprotective Effect of Aliskiren Shown

Jody A. Charnow July 24, 2008

Aliskiren, an oral direct renin inhibitor, may have renoprotective effects that are independent of its BP-lowering effect in patients with type 2 diabetic nephropathy who are receiving the maximal recommended renoprotective treatment and optimal antihypertensive therapy, researchers report.

Intensive Glucose Control Found to Protect Kidneys

Jody A. Charnow June 10, 2008

Intensive glucose control with gliclazide (modified release) and other agents reduced the risk of nephropathy by one fifth in a large study of patients with type 2 diabetes.

Tighter Glycemic Control Beneficial

Debra Blair, MPH, RD, CSR December 01, 2007

Better glucose management can reduce mortality and morbidity in dialysis patients.

More Type 2 Diabetics Face ESRD

Jody A. Charnow October 23, 2007

End-stage renal disease (ESRD) is affecting a growing proportion of type 2 diabetics in Australia and New Zealand, a study found.

Telmisartan Offers Better Renoprotection

Jill Stein July 01, 2007

CHICAGO—Telmisartan (Micardis HCT), a novel angiotensin receptor blocker (ARB), and the older ARB losartan have similar BP-lowering efficacy in hypertensive patients with diabetic nephropathy, but treatment with the new agent is associated with larger reductions in proteinuria, new findings show.

Mechanisms of Diabetic Nephropathy

Raymond Townsend, MD April 24, 2007

The kidney consists of four basic tissue types: vessels, glomeruli, tubules, and interstitium. Each of these types may be influenced by different pathophysiologic mechanisms associated with diabetic nephropathy. Despite their variability, these mechanisms share common clinical outcomes including microalbuminuria, progesssion to end-stage renal disease, and increased risks of cardiovascular morbidity and mortality.

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On The Forefront

Boosting Renal Transplantation with Kidney Paired Donation

In the past five to 10 years, researchers have developed several techniques to overcome donor incompatibility, including paired donation. The following case illustrates the collaborative efforts between nephrologists and urologists at the Glickman Urological and Kidney Institute.