Good Long-Term Prognosis for Benign IgA Nephropathy

Good Long-Term Prognosis for Benign IgA Nephropathy
Good Long-Term Prognosis for Benign IgA Nephropathy

The long-term prognosis for Caucasian patients with immunoglobulin A (IgA) nephropathy with benign presentation (consisting of only minor urinary abnormalities and normal renal function) is excellent, without special treatment, data show.

Eduardo Gutiérrez, MD, of the Hospital 12 de Octubre in Madrid, and colleagues conducted a long-term study involving 141 Caucasian patients with biopsy-proven IgA nephropathy with normal kidney function, minor abnormalities at presentation, and who were not taking immunosuppressants or corticosteroids. Participants were followed for a median of 108 months.

After 10, 15, and 20 years, the researchers found that 96.7%, 91.9%, and 91.9% of patients, respectively, maintained serum creatinine levels below a 50 percent increase from baseline, according to an online report in the Journal of the American Society of Nephrology. No patient developed end-stage renal disease. After a median of 48 months of follow-up, clinical remission had occurred in 37.5% of patients. At the end of follow-up, the median proteinuria was 0.1 g/24 hours and 29.1% of patients had no proteinuria. Hypertension increased from 16.3% at presentation to 21.3% at the end of the study. Overall, 41.8% of patients were treated with renin-angiotensin blockers.

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