Wine May Reduce CVD Risk in Diabetics
Benefits observed for moderate consumption, but risk is increased for heavy consumption.
Moderate alcohol intake, particularly wine consumption, is associated with reduced risks of cardiovascular events in patients with type 2 diabetes, according to research published online in Diabetes Care.
Juuso I. Blomster, M.D., of the University of Turku in Finland, and colleagues investigated the effects of alcohol use on cardiovascular health for participants in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.
The researchers found that, during a median follow-up of five years, patients with diabetes who reported moderate alcohol consumption, compared with those who reported no alcohol consumption, had fewer cardiovascular events, including cardiovascular death, myocardial infarction, and stroke (adjusted hazard ratio [aHR], 0.83; 95 percent confidence interval [CI], 0.72 to 0.95; P = 0.008); fewer microvascular complications, including new or worsening nephropathy or retinopathy (aHR, 0.85; 95 percent CI, 0.73 to 0.99; P = 0.03); and lower all-cause mortality (aHR, 0.87; 95 percent CI, 0.75 to 1.00; P = 0.05).
Greater benefits were observed in participants who drank mostly wine. Compared with patients who reported no alcohol consumption, those who reported heavy alcohol use had dose-dependent increased risks of cardiovascular events and all-cause mortality.
"In patients with type 2 diabetes, moderate alcohol use, particularly wine consumption, is associated with reduced risks of cardiovascular events and all-cause mortality," the authors write.
Several study authors report financial ties to Servier, which contributed funding to the ADVANCE study.