Premixed Insulin Ups Hypoglycemia in Hospitalized Diabetes Patients

This article originally appeared here.
Patients receiving premixed insulin experienced similar glycemic control as basal-bolus regimen but elevated frequency of hypoglycemia.
Patients receiving premixed insulin experienced similar glycemic control as basal-bolus regimen but elevated frequency of hypoglycemia.

(HealthDay News) -- For hospitalized patients with diabetes, treatment with premixed insulin results in similar glycemic control but higher frequency of hypoglycemia compared with a basal-bolus regimen, according to a study published online in Diabetes Care.

Virginia Bellido, from Hospital Universitario Central de Asturias in Spain, and colleagues conducted a prospective, open-label trial in which inpatients with diabetes were randomized to receive a basal-bolus regimen with glargine once daily and glulisine before meals (33 patients) or premixed human insulin twice daily (30% regular insulin, 70% PH insulin; 39 patients).

The study was stopped prematurely at the first prespecified interim analysis because of an increased frequency of hypoglycemia >50% in patients treated with premixed human insulin. The researchers found that 64 and 24% of patients treated with premixed insulin and a basal-bolus regimen, respectively, experienced one or more episodes of hypoglycemia (P < 0.001). After the first day of treatment, there were no differences seen in mean daily blood glucose level between the groups. In 55.9% of blood glucose readings in the basal-bolus group and 54.3% in the premixed insulin group, a blood glucose target between 80 and 180 mg/dL before meals was achieved (P = 0.23).

"Inpatient treatment with premixed human insulin resulted in similar glycemic control but in significantly higher frequency of hypoglycemia compared with treatment with basal-bolus insulin regimen in hospitalized patients with diabetes," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Sanofi-Aventis, which funded the study.

Source

  1. Bellido1, V; Suarez, L; Galiana Rodriguez, M; et al. Diabetes Care October 12, 2015; doi: 10.2337/dc15-0160.
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