Intranasal Glucagon Treats Hypoglycemia in Type 1 Diabetes

This article originally appeared here.
Noninferior to IM glucagon for treating insulin-induced hypoglycemia in adults with type 1 diabetes.
Noninferior to IM glucagon for treating insulin-induced hypoglycemia in adults with type 1 diabetes.

(HealthDay News) -- For patients with type 1 diabetes, intranasal glucagon is effective for treating insulin-induced hypoglycemia, according to a study published online in Diabetes Care.

Michael R. Rickels, MD, from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues compared needle-free intranasal glucagon preparation with intramuscular glucagon for treatment of insulin-induced hypoglycemia in a randomized crossover noninferiority trial. Participants included 75 adults (mean age, 33 years; median diabetes duration, 18 years) with type 1 diabetes at 8 clinical centers.

The researchers found that the mean plasma glucose at time of glucagon administration was 48 ± 8 mg/dL at the intranasal visits and 49 ± 8 mg/dL at the intramuscular visits. All but one intranasal visit (98.7%) and all intramuscular visits (100%) met success criteria (increase in plasma glucose to ≥70 mg/dL or ≥20 mg/dL from the glucose nadir within 30 minutes after receiving glucagon). For intranasal and intramuscular preparation, the mean time to success was 16 and 13 minutes, respectively (P < 0.001). Head/facial discomfort was reported during 25 and 9% of intranasal and intramuscular dosing visits, respectively; nausea occurred in 35 and 38% of visits, respectively.

"Intranasal glucagon was highly effective in treating insulin-induced hypoglycemia in adults with type 1 diabetes," the authors write.

Several authors disclosed financial ties to pharmaceutical and medical device companies, including Locemia Solutions, which funded the study and provided the intranasal glucagon product.

Source

  1. Rickels MR, Ruedy KJ, Foster NC, et al. Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study. Diabetes Care. doi: 10.2337/dc15-1498.
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