Early Losartan No Better at Slowing Renal Decline
Findings in American-Indians with type 2 diabetes and urine albumin/creatinine ratio <300 mg/g
(HealthDay News) -- For American-Indians with type 2 diabetes, early administration of losartan does not slow progression of glomerular filtration rate (GFR) decline, according to a study published online in Diabetes Care.
Stephanie K. Tanamas, PhD, from the National Institutes of Health in Phoenix, and colleagues examined whether early administration of losartan slows progression of kidney disease in a 6-year trial in 169 American-Indians with type 2 diabetes. Participants with urine albumin/creatinine ratio <300 mg/g were randomized to receive losartan or placebo (84 and 85, respectively). The primary outcome was a reduction in GFR to ≤60 mL/min or half the baseline value (for those who entered with GFR <120 mL/min). Participants were followed for up to 12 years post-trial, with treatment managed outside the study.
The researchers found that treatment with renin-angiotensin system inhibitors was equivalent in both groups after completion of the clinical trial. During a median of 13.5 years following randomization, 29 and 35 participants originally assigned to losartan and placebo, respectively, reached the primary GFR outcome, with a hazard ratio of 0.72 (95 percent confidence interval, 0.44 to 1.18).
"We found no evidence of an extended benefit of early losartan treatment on slowing GFR decline in persons with type 2 diabetes," the authors write.
The study was funded in part by Merck, which provided the study drug and placebo tablets.
1. Tanamas SK, Saulnier PJ, Fufaa GD, Wheelock KM, Weil EJ, Hanson RL, Knowler WC, Bennett PH, and Nelson RG. Long-Term Effect of Losartan on Kidney Disease in American Indians With Type 2 Diabetes: A Follow-up Analysis of a Randomized Clinical Trial. Diabetes Care 2016 Sep; dc160795. doi:10.2337/dc16-0795