MACE Risk Similar With, Without Diabetes and No CAD
In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events.
(HealthDay News) — For patients undergoing coronary angiography (CAG), those with and without diabetes without coronary artery disease (CAD) have the same risk of death, cardiac death, and myocardial infarction, according to a study published online in Diabetes Care.
Kevin KW Olesen, MD, from the Aarhus University Hospital in Denmark, and colleagues stratified a population-based cohort of patients registered in the Western Denmark Heart Registry who underwent CAG according to the presence or absence of obstructive CAD and diabetes. Data were included for 93,866 patients, of whom 13.4% had diabetes at the time of CAG.
During a median follow-up of 4.1 years, the researchers found that the adjusted risk of death (rate ratio, 1.03; 95% confidence interval, 0.92 to 1.15), cardiac death (rate ratio, 1.21; 95% confidence interval, 0.90 to 1.64), and myocardial infarction (rate ratio, 0.88; 95% confidence interval, 0.65 to 1.17) was the same for patients with and without diabetes without obstructive CAD. Compared to patients without diabetes and CAD, patients with diabetes without CAD were more often treated with statins (75.3% vs 46.0%) and aspirin (65.7% vs 52.7%).
"In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events as patients without diabetes in the absence of angiographically significant CAD," the authors write.
One author was supported by a grant from the Program for Clinical Research Infrastructure established by the Lundbeck and Novo Nordisk Foundations.
- Olesen KKW, Madsen M, Egholm G, et al. Patients With and Without Diabetes Without Significant Angiographic Coronary Artery Disease Have the Same Risk of Myocardial Infarction in a Real-World Population Receiving Appropriate Prophylactic Treatment. Diabetes Care. 8 June 2017. doi: 10.2337/dc16-2388