Diabetes News Archive
Addition of CCTA-detected obstructive coronary artery disease to risk factors ups prediction of MACE.
The rates of overall symptomatic hypoglycemia for insulin degludec vs insulin glargine were 185.6 vs 265.4 episodes per 100 PYEs.
Patients who achieved SVR had a greater drop in HbA1c associated with antiviral treatment than those who sustained treatment failure.
Between 2002 and 2013, heart failure hospitalizations declined by 30.8% nationwide, and continue to drop.
Therapeutic inertia was seen in 18.1% of the 12,730 patients with HbA1c of ≥8% at baseline or during follow-up.
The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.
The researchers found that new-onset AF correlated with increased risk of heart failure in multivariable models.
Earlier treatment remained significantly correlated with lower in-hospital mortality in multivariate analysis.
In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events.
What's important is that doctors and other health-care providers, as well as patients, don't just assume these differences are normal and inconsequential.
The researchers found no differences between the groups in how well their blood glucose levels were controlled or in their quality of life.
In 96.2% of the episodes, blood glucose levels returned to normal within 30 minutes.
The researchers found that the primary outcome of first occurrence of an adjudicated major cardiovascular event occurred in 8.5% and 9.3% of patients in the degludec and glargine groups, respectively.
Study findings suggest that the medication may offer renal protection.
The investigators found that patients taking SGLT2 inhibitors were approximately twice as likely to develop diabetic ketoacidosis than those taking DPP4 inhibitors.
The NMTT is a reliable insulin secretion test in patients with type 2 diabetes, except those in a hyperglycemic state.
Participants lost 0.3% of body weight for every additional program session attended and every 30 minutes of activity reported.
There was a net 20% steps/day increase in active vs. control arm participants.
Amputations of the toe and middle of the foot were the most common, but leg amputations below and above the knee also occurred.
NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.
Finding could explain the association between obesity and diabetes and the development of kidney stones.
The incidence of NODAT was 33.8% among patients who switched to everolimus and 36.4% among those who stayed on calcineurin inhibitors.
In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.
The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.
A short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss.
The largest numbers of diet-related cardiometabolic deaths were related to high sodium, low nuts/seeds, high processed meats, low seafood omega-3 fats, low vegetables, low fruits, and high SSBs.
Among 187 metabolites identified in urine metabolic profiles, 3 metabolites were significantly higher in obese youth with T2D than in non-diabetic obese youth.
CSII produced a significantly greater reduction in HbA1c than multiple daily injections, and the treatment difference increased with baseline HbA1c .
Hyperglycemia from genetics increases the risk of coronary artery disease separately from type 2 diabetes and other CAD risk factors.
Isocaloric diets high in animal or plant protein allow similar improvements of metabolism and cardiovascular risk factors in T2DM patients.
These cardiovascular profiles during enteral nutrient exposure may have implications for postprandial hypotension.
The study found that many patients who had a hypoglycemic episode also had high increased odds of cardiovascular disease or death.
The 2017 Updates focus on pharmacologic approaches to glycemic treatment of type 2 diabetes.
Timing of intensification of OAD therapy led to greater reductions in HbA1c and lower risks of complications.
In short-term treatment duration, there was no increased risk of myocardial infarction stroke or heart failure using DPP-4i vs SU/TZD.
Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.
Patients with diabetes had higher cumulative rates of 1-year all-cause death, CVD death, and HF hospitalization.
Patients who underwent surgical procedures had a greater mean percentage reduction from baseline in glycated hemoglobin level than did patients who received medical therapy alone.
The largest difference between adolescents with type 2 diabetes vs type 1 diabetes was obesity.
Among the etiologies of readmission, cardiac causes including heart failure and coronary artery disease were most common.
Statistically significant increases in BP, MAP, and serum lipid levels were observed with LY2409021 treatment at a dose that lowered HbA1c and glucose levels.
Participants with high TG and low HDL levels had a 1.32-fold greater HR for CHD than those with normal TG and normal HDL levels.
Swedish smokeless tobacco (snus) increases insulin resistance and the risk of type 2 diabetes.
Dapagliflozin was associated with lower risk of both all-cause mortality and CVD, whereas DPP-4i was only associated with lower risk of all-cause mortality.
Important concepts of obesity prevention and treatment were poorly represented.
Combination therapy was effective in lowering the HbA1c independent of sex, ethnicity, BMI, or baseline HbA1c.
An estimated 12.3% of Americans over the age of 21 have masked hypertension.
A small set of serum protein biomarkers combined with clinical variables, enhances the prediction of renal function loss over a wide range of baseline eGFR values.
Sitagliptin did not significantly impact the primary composite, death, heart failure hospitalization, severe hypoglycemia, rates of acute pancreatitis and pancreatic cancer, or serious adverse events.
Serum levels of 7 modified metabolites were associated with renal function decline and time to ESRD.
The continued observation of heterogeneity of treatment response by baseline lipids suggests that fenofibrate therapy may reduce CVD in patients with diabetes.
To receive top ratings, a diet has to be relatively easy to follow, nutritious, safe, effective for weight loss, and protective against diabetes and heart disease.
Patients with type 2 diabetes had higher prevalence of CHB than the controls in the overall population.
The Indian Health Service has made progress by applying population health and team-based approaches to diabetes and kidney care.
The insulin response to an intravenous glucose load increased during treatment with empagliflozin, and further improved after the addition of linagliptin.
ACP recommends that clinicians add oral medications in patients with type 2 diabetes when lifestyle modifications have failed to improve hyperglycemia.
Breaking sitting with standing and light-intensity walking effectively improved 24-hour glucose levels and improved insulin sensitivity in individuals with type 2 diabetes.
Privately insured lower-income respondents with diabetes report significant decreases in service use for primary care, checkups, and specialty visits.
Each additional hour of patient in-hospital sleep correlated with lower proportional odds of a higher glucose category the next morning.
Coverage for the influenza vaccination coverage is more common than pneumonia or hepatitis B vaccination.
Urine haptoglobin, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with type 2 diabetes.
A lower BP was associated with a substantially lower risk of adverse renal outcomes, regardless of the prior assigned glycemic control strategy.
Blood glucose profile at discharge using CGM seems useful to predict HbA1c level after discharge in patients with type 2 diabetes.
The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up.
Conditions such as chronic illness, mental illness, or substance abuse commonly overlap with each other and with poverty, which contributes to poor health.
In patients with diabetes, deferred revascularization is associated with poor medium-term outcomes
In cross-sectional analyses there was a 13% reduction in prevalent diabetes with reduction of chemical exposures.
Diabetes patients are urged to physically move at least every 30 minutes throughout the day to improve blood glucose management.
Insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices for patients with type 2 diabetes.
Use of the glucagon-like peptide-1 receptor agonist lowered 24-hour urinary albumin excretion rate by 32% over 12 weeks versus placebo.
Those who exercised at least 150 minutes a week had a 26% lower risk of developing type 2 diabetes, and exercising more than the recommended 150 minutes has even greater benefits in reducing the risk of diabetes.
Treatment with saxagliptin was associated with improvement in ACR categories for individuals with normoalbuminuria, microalbuminuria, and macroalbuminuria.
Overweight women without diabetes who ate a high-protein diet did not show improvement in insulin sensitivity.
The prevalence of childhood and adolescent overweight and obesity leads to a substantially increased future diagnosis of diabetes.
Genetic increase of SBP levels are linked to greater risk of type 2 diabetes.
Findings in large cohort of patients with diabetes over 4 years of follow-up.
Blacks have increased incidence of hypertension, diabetes mellitus, dyslipidemia, but not a-fib.
Every additional absent dorsalis pedis or posterior tibial pulse linked to increased risk of all outcomes.
End-stage renal disease is 32% more likely to develop in patients with C-reactive protein levels of 6.9 mg/L or higher vs 3.0 mg/L or lower.
Effect estimates are much more significant for individuals diagnosed with prediabetes.
Trajectories in eGRF decline were linear for about 87% of patients, accelerating for 6%.
Study confirms the noninferiority of semaglutide.
Findings in American-Indians with type 2 diabetes and urine albumin/creatinine ratio 300 mg/g
Patients with diabetes had a significant 42% increased risk of recurrence of cancer and 79% increased risk of progression.
AGEs improve RFL prediction in American-Indians with type 2 diabetes.
No change in effective renal plasma flow, other intrarenal hemodynamic measures.
Add-on mineralocorticoid receptor antagonist therapy increased serum potassium by 0.4 mEq.
Risk for CV events and microvascular (with exception of peripheral neuropathy) complications down.
At 24 weeks, greater HbA1c reductions were seen with combination empagliflozin + metformin therapy.
Researchers suggest steaming, poaching, and stewing for better health.
Findings in African-American patients with new-onset diabetic ketoacidosis and severe hyperglycemia.
Researchers found that HbA1c was reduced by 1.2% at 6 months among study participants.
Metformin-associated 1-year risk of acute dialysis increased by 50.3 per 100,000 individuals.
Significantly higher nighttime systolic blood pressure, especially in patients with diabetes and low eGFR.
Increases in cardiovascular death, cancer death, noncardiovascular noncancer death in men, women
The odds of developing anemia were 2-fold greater among patients with than without diabetes mellitus.
Doubling of serum creatinine occured in 1,262 patients studied.
Men who used the medications prior to radical prostatectomy had 83% greater odds of Gleason 7-10 tumors compared with non-users.
The effect of gout on type 2 diabetes risk was more profound in women than men.
The prevalence of ED is 30% higher among men who have vitamin D levels below 20 ng/mL versus those with levels of 30 ng/mL or higher.
Renal and Urology News Articles
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)