Diabetes News Archive

More Intense Treatment, Worse Quality of Life in Diabetes

More Intense Treatment, Worse Quality of Life in Diabetes

Measuring the quality of life and status of health is imperative in patients with diabetes.

FDA Approves Short Acting Insulin Drug for Diabetes

FDA Approves Short Acting Insulin Drug for Diabetes

The FDA just approved a new short-acting insulin drug, Admelog, for patients with either T1D or T2D.

Primary Care-led Weight Loss Leads to T2DM Remission

Primary Care-led Weight Loss Leads to T2DM Remission

Remission was linked to 46% patients in intensive weight management programs.

FDA Approves Semiglutide for Type 2 Diabetes

FDA Approves Semiglutide for Type 2 Diabetes

Semaglutide helps patients with diabetes reduce blood glucose levels and lower body weight.

Antibiotic-Diabetes Link Questioned

Antibiotic-Diabetes Link Questioned

Lifestyle and clinical factors could have been misinterpreted, linking antibiotics to risk of diabetes.

Greater Adherence With Certain Type 2 Diabetes Meds

Greater Adherence With Certain Type 2 Diabetes Meds

Sulfonylureas and thiazolidinediones adherence was stronger than metformin adherence.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Severe Hypoglycemia a Red Flag for Cardiovascular Risks

Severe Hypoglycemia a Red Flag for Cardiovascular Risks

Severe hypoglycemia is associated with coronary heart disease, cardiovascular mortality, and cancer mortality.

Diabetes Disparities Tied to Chemically Induced Endocrine Inhibition

Diabetes Disparities Tied to Chemically Induced Endocrine Inhibition

Chemicals that inhibit endocrine functions may be associated with contrasts in diabetes-linked racial and socioeconomic disparities.

Diabetes With High BMI Ups Risk of Some Cancers

Diabetes With High BMI Ups Risk of Some Cancers

The combined effects of high BMI and diabetes resulted in 5.6% of all incident cancers in 2012.

CVD Hospitalization Rates Have Declined for Diabetes Patients

CVD Hospitalization Rates Have Declined for Diabetes Patients

For patients with diabetes, there was a significant decrease in hospitalization rates for acute coronary syndrome, cardiac dysrhythmia, heart failure, and certain strokes.

Increasing β-blocker Dose May Lower Death Risk in CHF With Diabetes

Increasing β-blocker Dose May Lower Death Risk in CHF With Diabetes

Effect is larger in chronic heart failure patients with diabetes than CHF patients without diabetes.

Type 2 Diabetes Trends: Metformin Use Up, Sulfonylurea Use Down

Type 2 Diabetes Trends: Metformin Use Up, Sulfonylurea Use Down

But sulfonylureas still most common drugs initiated as second-line treatment.

No Improvement in Glycemic Control in Recent Decade

No Improvement in Glycemic Control in Recent Decade

But significant improvements in HbA1c testing and awareness seen, except in those aged 20 to 44.

Sudden Cardiac Death Risk Increased for Children With Diabetes

Sudden Cardiac Death Risk Increased for Children With Diabetes

Increased risk seen for both all-cause mortality, sudden cardiac death in young people with diabetes.

ESRD Risk Low for Type 1 Diabetes

ESRD Risk Low for Type 1 Diabetes

Findings among a large study of Norwegian children followed for 40-plus years.

Hypertension, Diabetes at Hemodialysis Initiation Increasing

Hypertension, Diabetes at Hemodialysis Initiation Increasing

From 1995 to 2015, the prevalence of hypertension and diabetes among patients starting hemodialysis increased from 67.9% to 87.6% and from 43.1% to 59.6%, respectively.

Statins May Raise Odds of Type 2 Diabetes in Those at High Risk

Statins May Raise Odds of Type 2 Diabetes in Those at High Risk

In any Diabetes Prevention Program treatment group, statin use tied to increased diabetes risk.

Most Type 1 Diabetes Patients Have Kidney Disease

Most Type 1 Diabetes Patients Have Kidney Disease

Incidence of end-stage renal disease has declined but affects substantial portion of long-term T1D patients.

Sudden Cardiac Death Top Culprit in Diabetes With Atherosclerosis

Sudden Cardiac Death Top Culprit in Diabetes With Atherosclerosis

27% of CV deaths in diabetes patients with atherosclerotic CVD are categorized as sudden death.

New Guidelines Released for Type 2 Diabetes

New Guidelines Released for Type 2 Diabetes

Individualized management should include education, glycemic management plans, target HbA1c.

Hospitalization, Death in Heart Failure Modified by HbA1c

Hospitalization, Death in Heart Failure Modified by HbA1c

Stratification of T2D by HbA1c shows U-shaped associations for first hospitalization and mortality.

Greater Heart Disease Benefits From Yoga Aerobics Combo

Greater Heart Disease Benefits From Yoga Aerobics Combo

Greater improvement in CHD risk factors for combined intervention versus either alone.

Oral Semaglutide Increases Glycemic Control in Type 2 Diabetes

Oral Semaglutide Increases Glycemic Control in Type 2 Diabetes

Phase 3 studies next to assess longer-term/clinical outcomes, safety.

Oral Hypoglycemic Drugs With Insulin Lower HbA1c in Type 2 Diabetes

Oral Hypoglycemic Drugs With Insulin Lower HbA1c in Type 2 Diabetes

Adding sulfonylurea or metformin to insulin decreases HbA1c about 1

Case: Venovenous Hemodiafiltration Resolves Metformin Overdose

Case: Venovenous Hemodiafiltration Resolves Metformin Overdose

Case report describes treatment of female patient who attempted suicide with metformin overdose.

DPP4i Plus AGI Ups Glycemic Control in Type 2 Diabetes

DPP4i Plus AGI Ups Glycemic Control in Type 2 Diabetes

Greater drop in HbA1c with DPP4i added to alpha glucosidase inhibitor, with no increase in weight.

Insulin Dose Does Not Reflect Cardiovascular Events

Insulin Dose Does Not Reflect Cardiovascular Events

Similar findings among individuals with diabetes able to achieve normoglycemia.

Weight Loss Underappreciated for Type 2 Diabetes Remission

Weight Loss Underappreciated for Type 2 Diabetes Remission

Primary aim of diagetes management is lowering blood glucose or glycated hemoglobin (HbA1c) concentrations.

First-line Diabetes Rx Failure Attributed to Nonadherence

First-line Diabetes Rx Failure Attributed to Nonadherence

Second-line treatment often initiated without evidence of recommended use of first-line treatment.

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Instead, sensor is implanted below skin in patients with diabetes.

Many Medicare Recipients Overtreated for Diabetes

Many Medicare Recipients Overtreated for Diabetes

Study of Medicare patients shows overtreatment for diabetes is rarely deintensified.

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

The results demonstrated a tendency for a decrease in LDL-C level at 24 weeks in the ANA group, and improvement was mediated through the suppression of apoB-100 synthesis.

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Administration of exenatide in patients with type 2 diabetes at a wide range of cardiovascular risk appeared not to cause an increase in their overall cardiovascular risk.

2017 Standards of Medical Care in Diabetes Updated

2017 Standards of Medical Care in Diabetes Updated

This synopsis focuses on recommendations from the 2017 Standards of Care about monitoring and pharmacologic approaches to glycemic management for type 1 diabetes.

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

The researchers found that, compared with placebo, diacerein reduced HbA1c by 0.35% in the intention-to-treat analysis and by 0.41% in the per-protocol analysis.

Falling Insulin Requirement May Signal Placental Dysfunction

Falling Insulin Requirement May Signal Placental Dysfunction

Among pregnant women with FIR at 25, 30, and 36 weeks, the ratio of soluble fms-like tyrosine kinase 1 to placental growth factor was significantly higher.

Alcohol Consumption May Guard Against Diabetes

Alcohol Consumption May Guard Against Diabetes

Frequent consumption of alcohol is associated with the lowest risk of diabetes.

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

After 11 pounds gained, the risk of diabetes went up 31%, hypertension 14%, and cardiovascular disease 8%.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

The addition of V/S ratio to age, eGFR, BNP, antiplatelet agents, and HbA1c significantly improved classification performance for CVD.

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Meta-analysis of studies conducted around the world found that men with diabetes have more than 3.5 times increased risk for erectile dysfunction.

Early Menopause Might Up Type 2 Diabetes

Early Menopause Might Up Type 2 Diabetes

The researchers found that women who experienced premature menopause were 3.7 times more likely to develop diabetes.

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

The cardiac biomarker data provide support for the beneficial cardiovascular effect of sodium glucose co-transporter 2 inhibitors in T2DM.

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Diabetes patients pursuing lifestyle interventions had a significantly increased risk of frailty fracture compared to diabetes support and education intervention patients.

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

Diabetes was seventh leading cause of death in 2015 in United States, according to report.

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Addition of CCTA-detected obstructive coronary artery disease to risk factors ups prediction of MACE.

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

The rates of overall symptomatic hypoglycemia for insulin degludec vs insulin glargine were 185.6 vs 265.4 episodes per 100 PYEs.

Glycemic Control Improves With Hepatitis C Treatment

Glycemic Control Improves With Hepatitis C Treatment

Patients who achieved SVR had a greater drop in HbA1c associated with antiviral treatment than those who sustained treatment failure.

Hospitalizations for Heart Failure Decreasing in US

Hospitalizations for Heart Failure Decreasing in US

Between 2002 and 2013, heart failure hospitalizations declined by 30.8% nationwide, and continue to drop.

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Therapeutic inertia was seen in 18.1% of the 12,730 patients with HbA1c of ≥8% at baseline or during follow-up.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Four Risk Factors Account for Most Heart Failure in A-Fib

Four Risk Factors Account for Most Heart Failure in A-Fib

The researchers found that new-onset AF correlated with increased risk of heart failure in multivariable models.

Early Loop Diuretic Linked With Fewer Deaths in Heart Failure

Early Loop Diuretic Linked With Fewer Deaths in Heart Failure

Earlier treatment remained significantly correlated with lower in-hospital mortality in multivariate analysis.

MACE Risk Similar With, Without Diabetes and No CAD

MACE Risk Similar With, Without Diabetes and No CAD

In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events.

HbA1c Influenced by Race, Socioeconomic Factors

HbA1c Influenced by Race, Socioeconomic Factors

What's important is that doctors and other health-care providers, as well as patients, don't just assume these differences are normal and inconsequential.

Glucose Self-Monitoring Doesn't Improve HbA1c

Glucose Self-Monitoring Doesn't Improve HbA1c

The researchers found no differences between the groups in how well their blood glucose levels were controlled or in their quality of life.

Nasal Glucagon Effectively Treats Hypoglycemic Episodes

Nasal Glucagon Effectively Treats Hypoglycemic Episodes

In 96.2% of the episodes, blood glucose levels returned to normal within 30 minutes.

Insulin Degludec Noninferior to Glargine for CV Events in T2DM

Insulin Degludec Noninferior to Glargine for CV Events in T2DM

The researchers found that the primary outcome of first occurrence of an adjudicated major cardiovascular event occurred in 8.5% and 9.3% of patients in the degludec and glargine groups, respectively.

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Study findings suggest that the medication may offer renal protection.

Diabetic Ketoacidosis Risk Up With SGLT2 Inhibitors in T2DM

Diabetic Ketoacidosis Risk Up With SGLT2 Inhibitors in T2DM

The investigators found that patients taking SGLT2 inhibitors were approximately twice as likely to develop diabetic ketoacidosis than those taking DPP4 inhibitors.

Normal Meal Tolerance Test Useful for Type 2 Diabetes Management

Normal Meal Tolerance Test Useful for Type 2 Diabetes Management

The NMTT is a reliable insulin secretion test in patients with type 2 diabetes, except those in a hyperglycemic state.

National Diabetes Prevention Program Shows Early Success

National Diabetes Prevention Program Shows Early Success

Participants lost 0.3% of body weight for every additional program session attended and every 30 minutes of activity reported.

Step Count Rx Helps Patients Get More Fit

Step Count Rx Helps Patients Get More Fit

There was a net 20% steps/day increase in active vs. control arm participants.

FDA: Canagliflozin May Increase Risk of Foot, Leg Amputations

FDA: Canagliflozin May Increase Risk of Foot, Leg Amputations

Amputations of the toe and middle of the foot were the most common, but leg amputations below and above the knee also occurred.

PCSK9 Linked to New-Onset Diabetes After Kidney Transplantation

PCSK9 Linked to New-Onset Diabetes After Kidney Transplantation

NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.

Stone Formation Linked to Hemoglobin A1c Levels

Stone Formation Linked to Hemoglobin A1c Levels

Finding could explain the association between obesity and diabetes and the development of kidney stones.

NODAT Risk Similar After Switching From CNIs to Everolimus

NODAT Risk Similar After Switching From CNIs to Everolimus

The incidence of NODAT was 33.8% among patients who switched to everolimus and 36.4% among those who stayed on calcineurin inhibitors.

Diabetes Increases Post-Transplant Mortality Risk

Diabetes Increases Post-Transplant Mortality Risk

In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.

Obesity Ups Diabetes Risk Among Living Kidney Donors

Obesity Ups Diabetes Risk Among Living Kidney Donors

The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.

Brief, Intensive Lifestyle and Drug Treatment Improves Type 2 Diabetes

Brief, Intensive Lifestyle and Drug Treatment Improves Type 2 Diabetes

A short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss.

Poor Diet Blamed for Nearly 1 in 2 Heart Disease, Stroke, T2DM Deaths

Poor Diet Blamed for Nearly 1 in 2 Heart Disease, Stroke, T2DM Deaths

The largest numbers of diet-related cardiometabolic deaths were related to high sodium, low nuts/seeds, high processed meats, low seafood omega-3 fats, low vegetables, low fruits, and high SSBs.

Unique Urine Metabolite Profile ID'd for Obese Teens With T2DM

Unique Urine Metabolite Profile ID'd for Obese Teens With T2DM

Among 187 metabolites identified in urine metabolic profiles, 3 metabolites were significantly higher in obese youth with T2D than in non-diabetic obese youth.

Continuous Insulin Better Than Injections in Type 2 Diabetes

Continuous Insulin Better Than Injections in Type 2 Diabetes

CSII produced a significantly greater reduction in HbA1c than multiple daily injections, and the treatment difference increased with baseline HbA1c .

Genetic Hyperglycemia Ups CAD Risk, Apart From T2DM

Genetic Hyperglycemia Ups CAD Risk, Apart From T2DM

Hyperglycemia from genetics increases the risk of coronary artery disease separately from type 2 diabetes and other CAD risk factors.

Animal or Plant Protein Diet Aids Metabolism in Type 2 Diabetes

Animal or Plant Protein Diet Aids Metabolism in Type 2 Diabetes

Isocaloric diets high in animal or plant protein allow similar improvements of metabolism and cardiovascular risk factors in T2DM patients.

Metformin, Vildagliptin Affect BP Differently in Diabetes

Metformin, Vildagliptin Affect BP Differently in Diabetes

These cardiovascular profiles during enteral nutrient exposure may have implications for postprandial hypotension.

A Single Hypoglycemic Event Can Up Death Risk in Diabetes

A Single Hypoglycemic Event Can Up Death Risk in Diabetes

The study found that many patients who had a hypoglycemic episode also had high increased odds of cardiovascular disease or death.

Highlights From ADA's Standards of Medical Care in Diabetes

Highlights From ADA's Standards of Medical Care in Diabetes

The 2017 Updates focus on pharmacologic approaches to glycemic treatment of type 2 diabetes.

Immediate Intensification of Antidiabetic Rx Yields Better HbA1c

Immediate Intensification of Antidiabetic Rx Yields Better HbA1c

Timing of intensification of OAD therapy led to greater reductions in HbA1c and lower risks of complications.

No Increased Risks of Stroke, Heart Failure With DPP-4i

No Increased Risks of Stroke, Heart Failure With DPP-4i

In short-term treatment duration, there was no increased risk of myocardial infarction stroke or heart failure using DPP-4i vs SU/TZD.

Kidney Cancer Survival Better Among Metformin Users

Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.

Diabetes Increases Poor Outcomes in Heart Failure Patients

Diabetes Increases Poor Outcomes in Heart Failure Patients

Patients with diabetes had higher cumulative rates of 1-year all-cause death, CVD death, and HF hospitalization.

Bariatric Surgery Better Than Drugs Alone for Obese T2DM Patients

Bariatric Surgery Better Than Drugs Alone for Obese T2DM Patients

Patients who underwent surgical procedures had a greater mean percentage reduction from baseline in glycated hemoglobin level than did patients who received medical therapy alone.

Complications More Likely in Teens With Type 2 Diabetes

Complications More Likely in Teens With Type 2 Diabetes

The largest difference between adolescents with type 2 diabetes vs type 1 diabetes was obesity.

Hospital Readmission Common With Heart Failure

Hospital Readmission Common With Heart Failure

Among the etiologies of readmission, cardiac causes including heart failure and coronary artery disease were most common.

BP Boost May Limit Use of Glucagon Receptor Antagonist in T2DM

BP Boost May Limit Use of Glucagon Receptor Antagonist in T2DM

Statistically significant increases in BP, MAP, and serum lipid levels were observed with LY2409021 treatment at a dose that lowered HbA1c and glucose levels.

High Triglycerides, Low HDL-C Increase CHD, Stroke Risks

High Triglycerides, Low HDL-C Increase CHD, Stroke Risks

Participants with high TG and low HDL levels had a 1.32-fold greater HR for CHD than those with normal TG and normal HDL levels.

Smokeless Tobacco May Increase Risk of Type 2 Diabetes

Smokeless Tobacco May Increase Risk of Type 2 Diabetes

Swedish smokeless tobacco (snus) increases insulin resistance and the risk of type 2 diabetes.

Novel Oral GLDs Beat Insulin in Reducing T2DM Risks

Novel Oral GLDs Beat Insulin in Reducing T2DM Risks

Dapagliflozin was associated with lower risk of both all-cause mortality and CVD, whereas DPP-4i was only associated with lower risk of all-cause mortality.

Obesity Inadequately Addressed in Medical Licensing Exams

Obesity Inadequately Addressed in Medical Licensing Exams

Important concepts of obesity prevention and treatment were poorly represented.

Exenatide, Pioglitazone Improves Glycemic Control in T2DM

Exenatide, Pioglitazone Improves Glycemic Control in T2DM

Combination therapy was effective in lowering the HbA1c independent of sex, ethnicity, BMI, or baseline HbA1c.

Millions of US Adults May Have Masked Hypertension

Millions of US Adults May Have Masked Hypertension

An estimated 12.3% of Americans over the age of 21 have masked hypertension.

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

A small set of serum protein biomarkers combined with clinical variables, enhances the prediction of renal function loss over a wide range of baseline eGFR values.

Sitagliptin OK for Older Type 2 Diabetes Patients With CVD

Sitagliptin OK for Older Type 2 Diabetes Patients With CVD

Sitagliptin did not significantly impact the primary composite, death, heart failure hospitalization, severe hypoglycemia, rates of acute pancreatitis and pancreatic cancer, or serious adverse events.

Metabolites Linked to Faster Renal Decline, Failure in Type 1 Diabetes

Metabolites Linked to Faster Renal Decline, Failure in Type 1 Diabetes

Serum levels of 7 modified metabolites were associated with renal function decline and time to ESRD.

Fenofibrate May Reduce CVD in Statin-Treated T2DM Patients

Fenofibrate May Reduce CVD in Statin-Treated T2DM Patients

The continued observation of heterogeneity of treatment response by baseline lipids suggests that fenofibrate therapy may reduce CVD in patients with diabetes.

DASH Deemed Best Diet of the Year

DASH Deemed Best Diet of the Year

To receive top ratings, a diet has to be relatively easy to follow, nutritious, safe, effective for weight loss, and protective against diabetes and heart disease.

Hepatitis B More Prevalent in Type 2 Diabetes Patients

Hepatitis B More Prevalent in Type 2 Diabetes Patients

Patients with type 2 diabetes had higher prevalence of CHB than the controls in the overall population.

ESRD From Diabetes Declining in Native Americans

ESRD From Diabetes Declining in Native Americans

The Indian Health Service has made progress by applying population health and team-based approaches to diabetes and kidney care.

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