Diabetes News Archive

First-line Diabetes Rx Failure Attributed to Nonadherence

First-line Diabetes Rx Failure Attributed to Nonadherence

Second-line treatment often initiated without evidence of recommended use of first-line treatment.

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Instead, sensor is implanted below skin in patients with diabetes.

Many Medicare Recipients Overtreated for Diabetes

Many Medicare Recipients Overtreated for Diabetes

Study of Medicare patients shows overtreatment for diabetes is rarely deintensified.

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

The results demonstrated a tendency for a decrease in LDL-C level at 24 weeks in the ANA group, and improvement was mediated through the suppression of apoB-100 synthesis.

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Administration of exenatide in patients with type 2 diabetes at a wide range of cardiovascular risk appeared not to cause an increase in their overall cardiovascular risk.

2017 Standards of Medical Care in Diabetes Updated

2017 Standards of Medical Care in Diabetes Updated

This synopsis focuses on recommendations from the 2017 Standards of Care about monitoring and pharmacologic approaches to glycemic management for type 1 diabetes.

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

The researchers found that, compared with placebo, diacerein reduced HbA1c by 0.35% in the intention-to-treat analysis and by 0.41% in the per-protocol analysis.

Falling Insulin Requirement May Signal Placental Dysfunction

Falling Insulin Requirement May Signal Placental Dysfunction

Among pregnant women with FIR at 25, 30, and 36 weeks, the ratio of soluble fms-like tyrosine kinase 1 to placental growth factor was significantly higher.

Alcohol Consumption May Guard Against Diabetes

Alcohol Consumption May Guard Against Diabetes

Frequent consumption of alcohol is associated with the lowest risk of diabetes.

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

After 11 pounds gained, the risk of diabetes went up 31%, hypertension 14%, and cardiovascular disease 8%.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

The addition of V/S ratio to age, eGFR, BNP, antiplatelet agents, and HbA1c significantly improved classification performance for CVD.

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Meta-analysis of studies conducted around the world found that men with diabetes have more than 3.5 times increased risk for erectile dysfunction.

Early Menopause Might Up Type 2 Diabetes

Early Menopause Might Up Type 2 Diabetes

The researchers found that women who experienced premature menopause were 3.7 times more likely to develop diabetes.

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

The cardiac biomarker data provide support for the beneficial cardiovascular effect of sodium glucose co-transporter 2 inhibitors in T2DM.

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Diabetes patients pursuing lifestyle interventions had a significantly increased risk of frailty fracture compared to diabetes support and education intervention patients.

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

Diabetes was seventh leading cause of death in 2015 in United States, according to report.

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Addition of CCTA-detected obstructive coronary artery disease to risk factors ups prediction of MACE.

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

The rates of overall symptomatic hypoglycemia for insulin degludec vs insulin glargine were 185.6 vs 265.4 episodes per 100 PYEs.

Glycemic Control Improves With Hepatitis C Treatment

Glycemic Control Improves With Hepatitis C Treatment

Patients who achieved SVR had a greater drop in HbA1c associated with antiviral treatment than those who sustained treatment failure.

Hospitalizations for Heart Failure Decreasing in US

Hospitalizations for Heart Failure Decreasing in US

Between 2002 and 2013, heart failure hospitalizations declined by 30.8% nationwide, and continue to drop.

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Therapeutic inertia was seen in 18.1% of the 12,730 patients with HbA1c of ≥8% at baseline or during follow-up.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Four Risk Factors Account for Most Heart Failure in A-Fib

Four Risk Factors Account for Most Heart Failure in A-Fib

The researchers found that new-onset AF correlated with increased risk of heart failure in multivariable models.

Early Loop Diuretic Linked With Fewer Deaths in Heart Failure

Early Loop Diuretic Linked With Fewer Deaths in Heart Failure

Earlier treatment remained significantly correlated with lower in-hospital mortality in multivariate analysis.

MACE Risk Similar With, Without Diabetes and No CAD

MACE Risk Similar With, Without Diabetes and No CAD

In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events.

HbA1c Influenced by Race, Socioeconomic Factors

HbA1c Influenced by Race, Socioeconomic Factors

What's important is that doctors and other health-care providers, as well as patients, don't just assume these differences are normal and inconsequential.

Glucose Self-Monitoring Doesn't Improve HbA1c

Glucose Self-Monitoring Doesn't Improve HbA1c

The researchers found no differences between the groups in how well their blood glucose levels were controlled or in their quality of life.

Nasal Glucagon Effectively Treats Hypoglycemic Episodes

Nasal Glucagon Effectively Treats Hypoglycemic Episodes

In 96.2% of the episodes, blood glucose levels returned to normal within 30 minutes.

Insulin Degludec Noninferior to Glargine for CV Events in T2DM

Insulin Degludec Noninferior to Glargine for CV Events in T2DM

The researchers found that the primary outcome of first occurrence of an adjudicated major cardiovascular event occurred in 8.5% and 9.3% of patients in the degludec and glargine groups, respectively.

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Study findings suggest that the medication may offer renal protection.

Diabetic Ketoacidosis Risk Up With SGLT2 Inhibitors in T2DM

Diabetic Ketoacidosis Risk Up With SGLT2 Inhibitors in T2DM

The investigators found that patients taking SGLT2 inhibitors were approximately twice as likely to develop diabetic ketoacidosis than those taking DPP4 inhibitors.

Normal Meal Tolerance Test Useful for Type 2 Diabetes Management

Normal Meal Tolerance Test Useful for Type 2 Diabetes Management

The NMTT is a reliable insulin secretion test in patients with type 2 diabetes, except those in a hyperglycemic state.

National Diabetes Prevention Program Shows Early Success

National Diabetes Prevention Program Shows Early Success

Participants lost 0.3% of body weight for every additional program session attended and every 30 minutes of activity reported.

Step Count Rx Helps Patients Get More Fit

Step Count Rx Helps Patients Get More Fit

There was a net 20% steps/day increase in active vs. control arm participants.

FDA: Canagliflozin May Increase Risk of Foot, Leg Amputations

FDA: Canagliflozin May Increase Risk of Foot, Leg Amputations

Amputations of the toe and middle of the foot were the most common, but leg amputations below and above the knee also occurred.

PCSK9 Linked to New-Onset Diabetes After Kidney Transplantation

PCSK9 Linked to New-Onset Diabetes After Kidney Transplantation

NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.

Stone Formation Linked to Hemoglobin A1c Levels

Stone Formation Linked to Hemoglobin A1c Levels

Finding could explain the association between obesity and diabetes and the development of kidney stones.

NODAT Risk Similar After Switching From CNIs to Everolimus

NODAT Risk Similar After Switching From CNIs to Everolimus

The incidence of NODAT was 33.8% among patients who switched to everolimus and 36.4% among those who stayed on calcineurin inhibitors.

Diabetes Increases Post-Transplant Mortality Risk

Diabetes Increases Post-Transplant Mortality Risk

In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.

Obesity Ups Diabetes Risk Among Living Kidney Donors

Obesity Ups Diabetes Risk Among Living Kidney Donors

The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.

Brief, Intensive Lifestyle and Drug Treatment Improves Type 2 Diabetes

Brief, Intensive Lifestyle and Drug Treatment Improves Type 2 Diabetes

A short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss.

Poor Diet Blamed for Nearly 1 in 2 Heart Disease, Stroke, T2DM Deaths

Poor Diet Blamed for Nearly 1 in 2 Heart Disease, Stroke, T2DM Deaths

The largest numbers of diet-related cardiometabolic deaths were related to high sodium, low nuts/seeds, high processed meats, low seafood omega-3 fats, low vegetables, low fruits, and high SSBs.

Unique Urine Metabolite Profile ID'd for Obese Teens With T2DM

Unique Urine Metabolite Profile ID'd for Obese Teens With T2DM

Among 187 metabolites identified in urine metabolic profiles, 3 metabolites were significantly higher in obese youth with T2D than in non-diabetic obese youth.

Continuous Insulin Better Than Injections in Type 2 Diabetes

Continuous Insulin Better Than Injections in Type 2 Diabetes

CSII produced a significantly greater reduction in HbA1c than multiple daily injections, and the treatment difference increased with baseline HbA1c .

Genetic Hyperglycemia Ups CAD Risk, Apart From T2DM

Genetic Hyperglycemia Ups CAD Risk, Apart From T2DM

Hyperglycemia from genetics increases the risk of coronary artery disease separately from type 2 diabetes and other CAD risk factors.

Animal or Plant Protein Diet Aids Metabolism in Type 2 Diabetes

Animal or Plant Protein Diet Aids Metabolism in Type 2 Diabetes

Isocaloric diets high in animal or plant protein allow similar improvements of metabolism and cardiovascular risk factors in T2DM patients.

Metformin, Vildagliptin Affect BP Differently in Diabetes

Metformin, Vildagliptin Affect BP Differently in Diabetes

These cardiovascular profiles during enteral nutrient exposure may have implications for postprandial hypotension.

A Single Hypoglycemic Event Can Up Death Risk in Diabetes

A Single Hypoglycemic Event Can Up Death Risk in Diabetes

The study found that many patients who had a hypoglycemic episode also had high increased odds of cardiovascular disease or death.

Highlights From ADA's Standards of Medical Care in Diabetes

Highlights From ADA's Standards of Medical Care in Diabetes

The 2017 Updates focus on pharmacologic approaches to glycemic treatment of type 2 diabetes.

Immediate Intensification of Antidiabetic Rx Yields Better HbA1c

Immediate Intensification of Antidiabetic Rx Yields Better HbA1c

Timing of intensification of OAD therapy led to greater reductions in HbA1c and lower risks of complications.

No Increased Risks of Stroke, Heart Failure With DPP-4i

No Increased Risks of Stroke, Heart Failure With DPP-4i

In short-term treatment duration, there was no increased risk of myocardial infarction stroke or heart failure using DPP-4i vs SU/TZD.

Kidney Cancer Survival Better Among Metformin Users

Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.

Diabetes Increases Poor Outcomes in Heart Failure Patients

Diabetes Increases Poor Outcomes in Heart Failure Patients

Patients with diabetes had higher cumulative rates of 1-year all-cause death, CVD death, and HF hospitalization.

Bariatric Surgery Better Than Drugs Alone for Obese T2DM Patients

Bariatric Surgery Better Than Drugs Alone for Obese T2DM Patients

Patients who underwent surgical procedures had a greater mean percentage reduction from baseline in glycated hemoglobin level than did patients who received medical therapy alone.

Complications More Likely in Teens With Type 2 Diabetes

Complications More Likely in Teens With Type 2 Diabetes

The largest difference between adolescents with type 2 diabetes vs type 1 diabetes was obesity.

Hospital Readmission Common With Heart Failure

Hospital Readmission Common With Heart Failure

Among the etiologies of readmission, cardiac causes including heart failure and coronary artery disease were most common.

BP Boost May Limit Use of Glucagon Receptor Antagonist in T2DM

BP Boost May Limit Use of Glucagon Receptor Antagonist in T2DM

Statistically significant increases in BP, MAP, and serum lipid levels were observed with LY2409021 treatment at a dose that lowered HbA1c and glucose levels.

High Triglycerides, Low HDL-C Increase CHD, Stroke Risks

High Triglycerides, Low HDL-C Increase CHD, Stroke Risks

Participants with high TG and low HDL levels had a 1.32-fold greater HR for CHD than those with normal TG and normal HDL levels.

Smokeless Tobacco May Increase Risk of Type 2 Diabetes

Smokeless Tobacco May Increase Risk of Type 2 Diabetes

Swedish smokeless tobacco (snus) increases insulin resistance and the risk of type 2 diabetes.

Novel Oral GLDs Beat Insulin in Reducing T2DM Risks

Novel Oral GLDs Beat Insulin in Reducing T2DM Risks

Dapagliflozin was associated with lower risk of both all-cause mortality and CVD, whereas DPP-4i was only associated with lower risk of all-cause mortality.

Obesity Inadequately Addressed in Medical Licensing Exams

Obesity Inadequately Addressed in Medical Licensing Exams

Important concepts of obesity prevention and treatment were poorly represented.

Exenatide, Pioglitazone Improves Glycemic Control in T2DM

Exenatide, Pioglitazone Improves Glycemic Control in T2DM

Combination therapy was effective in lowering the HbA1c independent of sex, ethnicity, BMI, or baseline HbA1c.

Millions of US Adults May Have Masked Hypertension

Millions of US Adults May Have Masked Hypertension

An estimated 12.3% of Americans over the age of 21 have masked hypertension.

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

A small set of serum protein biomarkers combined with clinical variables, enhances the prediction of renal function loss over a wide range of baseline eGFR values.

Sitagliptin OK for Older Type 2 Diabetes Patients With CVD

Sitagliptin OK for Older Type 2 Diabetes Patients With CVD

Sitagliptin did not significantly impact the primary composite, death, heart failure hospitalization, severe hypoglycemia, rates of acute pancreatitis and pancreatic cancer, or serious adverse events.

Metabolites Linked to Faster Renal Decline, Failure in Type 1 Diabetes

Metabolites Linked to Faster Renal Decline, Failure in Type 1 Diabetes

Serum levels of 7 modified metabolites were associated with renal function decline and time to ESRD.

Fenofibrate May Reduce CVD in Statin-Treated T2DM Patients

Fenofibrate May Reduce CVD in Statin-Treated T2DM Patients

The continued observation of heterogeneity of treatment response by baseline lipids suggests that fenofibrate therapy may reduce CVD in patients with diabetes.

DASH Deemed Best Diet of the Year

DASH Deemed Best Diet of the Year

To receive top ratings, a diet has to be relatively easy to follow, nutritious, safe, effective for weight loss, and protective against diabetes and heart disease.

Hepatitis B More Prevalent in Type 2 Diabetes Patients

Hepatitis B More Prevalent in Type 2 Diabetes Patients

Patients with type 2 diabetes had higher prevalence of CHB than the controls in the overall population.

ESRD From Diabetes Declining in Native Americans

ESRD From Diabetes Declining in Native Americans

The Indian Health Service has made progress by applying population health and team-based approaches to diabetes and kidney care.

Empagliflozin With Add-On Linagliptin Effective After Metformin Failure

Empagliflozin With Add-On Linagliptin Effective After Metformin Failure

The insulin response to an intravenous glucose load increased during treatment with empagliflozin, and further improved after the addition of linagliptin.

ACP Updates Guidelines on Oral Treatments for Type 2 Diabetes

ACP Updates Guidelines on Oral Treatments for Type 2 Diabetes

ACP recommends that clinicians add oral medications in patients with type 2 diabetes when lifestyle modifications have failed to improve hyperglycemia.

Sitting Less, Moving More Improves Blood Glucose Control in Diabetes

Sitting Less, Moving More Improves Blood Glucose Control in Diabetes

Breaking sitting with standing and light-intensity walking effectively improved 24-hour glucose levels and improved insulin sensitivity in individuals with type 2 diabetes.

Deductibles Prevent Some Diabetes Pts From Seeking Care

Deductibles Prevent Some Diabetes Pts From Seeking Care

Privately insured lower-income respondents with diabetes report significant decreases in service use for primary care, checkups, and specialty visits.

Getting More Sleep May Lower Inpatient Hyperglycemia

Getting More Sleep May Lower Inpatient Hyperglycemia

Each additional hour of patient in-hospital sleep correlated with lower proportional odds of a higher glucose category the next morning.

CDC Reports Unequal Vaccination Coverage of Diabetes Patients

CDC Reports Unequal Vaccination Coverage of Diabetes Patients

Coverage for the influenza vaccination coverage is more common than pneumonia or hepatitis B vaccination.

Novel Biomarker Can Predict Kidney Damage in Type 2 Diabetes

Novel Biomarker Can Predict Kidney Damage in Type 2 Diabetes

Urine haptoglobin, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with type 2 diabetes.

Lower Blood Pressure May Protect Against Renal Events in T1DM

Lower Blood Pressure May Protect Against Renal Events in T1DM

A lower BP was associated with a substantially lower risk of adverse renal outcomes, regardless of the prior assigned glycemic control strategy.

Blood Glucose Level at Discharge Can Predict HbA1c

Blood Glucose Level at Discharge Can Predict HbA1c

Blood glucose profile at discharge using CGM seems useful to predict HbA1c level after discharge in patients with type 2 diabetes.

ESRD Uncommon Among Type 1 Diabetes Patients

ESRD Uncommon Among Type 1 Diabetes Patients

The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up.

1 in 2 Americans Have a Chronic Health Condition

1 in 2 Americans Have a Chronic Health Condition

Conditions such as chronic illness, mental illness, or substance abuse commonly overlap with each other and with poverty, which contributes to poor health.

Deferred Revascularization Worse for Diabetes Patients

Deferred Revascularization Worse for Diabetes Patients

In patients with diabetes, deferred revascularization is associated with poor medium-term outcomes

Reducing Chemical Exposure May Prevent Diabetes in Elderly

Reducing Chemical Exposure May Prevent Diabetes in Elderly

In cross-sectional analyses there was a 13% reduction in prevalent diabetes with reduction of chemical exposures.

New ADA Guidelines Say Diabetes Patients Should "Move More"

New ADA Guidelines Say Diabetes Patients Should "Move More"

Diabetes patients are urged to physically move at least every 30 minutes throughout the day to improve blood glucose management.

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices for patients with type 2 diabetes.

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Use of the glucagon-like peptide-1 receptor agonist lowered 24-hour urinary albumin excretion rate by 32% over 12 weeks versus placebo.

Walking After Meals Cuts Type 2 Diabetes Risk

Walking After Meals Cuts Type 2 Diabetes Risk

Those who exercised at least 150 minutes a week had a 26% lower risk of developing type 2 diabetes, and exercising more than the recommended 150 minutes has even greater benefits in reducing the risk of diabetes.

Saxagliptin Linked to Albuminuria Improvement

Saxagliptin Linked to Albuminuria Improvement

Treatment with saxagliptin was associated with improvement in ACR categories for individuals with normoalbuminuria, microalbuminuria, and macroalbuminuria.

High-Protein Diet Doesn't Aid Insulin Sensitivity in Women

High-Protein Diet Doesn't Aid Insulin Sensitivity in Women

Overweight women without diabetes who ate a high-protein diet did not show improvement in insulin sensitivity.

Teen Overweight, Obesity Predicts Diabetes Mortality

Teen Overweight, Obesity Predicts Diabetes Mortality

The prevalence of childhood and adolescent overweight and obesity leads to a substantially increased future diagnosis of diabetes.

Genetically Elevated Systolic BP May Up Type 2 Diabetes Risk

Genetically Elevated Systolic BP May Up Type 2 Diabetes Risk

Genetic increase of SBP levels are linked to greater risk of type 2 diabetes.

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Findings in large cohort of patients with diabetes over 4 years of follow-up.

Older Adults Have Many Cardiovascular Risk Factors

Older Adults Have Many Cardiovascular Risk Factors

Blacks have increased incidence of hypertension, diabetes mellitus, dyslipidemia, but not a-fib.

Absent Pulses Up Risk of Vascular Events, ESRD in Type 2 Diabetes

Absent Pulses Up Risk of Vascular Events, ESRD in Type 2 Diabetes

Every additional absent dorsalis pedis or posterior tibial pulse linked to increased risk of all outcomes.

High CRP Ups Kidney Failure Risk in Diabetic CKD Patients With Anemia

High CRP Ups Kidney Failure Risk in Diabetic CKD Patients With Anemia

End-stage renal disease is 32% more likely to develop in patients with C-reactive protein levels of 6.9 mg/L or higher vs 3.0 mg/L or lower.

Air Pollution May Increase Insulin Resistance Over Time

Air Pollution May Increase Insulin Resistance Over Time

Effect estimates are much more significant for individuals diagnosed with prediabetes.

eGFR Decline in Type 1 Diabetes Mostly Linear

eGFR Decline in Type 1 Diabetes Mostly Linear

Trajectories in eGRF decline were linear for about 87% of patients, accelerating for 6%.

Semaglutide Does Not Appear to Increase CV Risks

Semaglutide Does Not Appear to Increase CV Risks

Study confirms the noninferiority of semaglutide.

Early Losartan No Better at Slowing Renal Decline

Early Losartan No Better at Slowing Renal Decline

Findings in American-Indians with type 2 diabetes and urine albumin/creatinine ratio 300 mg/g

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