Antihyperglycemic Rx Patterns Shifting for CKD Patients

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Decrease in glyburide and thiazolidinedione Rx; increase in gliclazide, dipeptidyl peptidase-4 inhibitor.
Decrease in glyburide and thiazolidinedione Rx; increase in gliclazide, dipeptidyl peptidase-4 inhibitor.

(HealthDay News) -- Trends indicate a reduction in glyburide and thiazolidinedione prescriptions and increases in gliclazide and dipeptidyl peptidase-4 inhibitor prescriptions among older adults with diabetes and chronic kidney disease, according to a study published online in Diabetes, Obesity and Metabolism.

Kristin K. Clemens, MD, from Western University in London, Canada, and colleagues conducted a population-based study involving 144,252 older adults with diabetes and chronic kidney disease. The proportion of treated and newly treated patients prescribed insulin, sulphonylureas, alpha glucosidase inhibitors, metformin, thiazolidinediones, meglitinides, and dipeptidyl peptidase-4 inhibitors was examined in each study quarter (from April 1, 2004, through March 31, 2013). Prescription trends were further examined by stage of chronic kidney disease.

The researchers found that the predominant therapy prescribed was metformin (prescribed to 56.1% of treated patients). Decreases were seen in glyburide (glibenclamide) and thiazolidinedione prescriptions, while there were increases in gliclazide and dipeptidyl peptidase-4 inhibitor prescriptions. Glyburide was prescribed for up to 48.6% of patients with stage 3a to 5 chronic kidney disease or on chronic dialysis, while metformin was prescribed for up to 27.6% of those with stage 4 or 5 disease or on chronic dialysis.

"In patients with chronic kidney disease, there were trends towards safer antihyperglycemic medication prescribing," the authors write. "A considerable number of patients, however, continue to receive medications that should be avoided."

Two authors disclosed financial ties to the pharmaceutical industry.

Source

  1. Clemens KK, Liu K, Shariff S, et al. Secular trends in Antihyperglycemic Medication Prescriptions in Older Adults with Diabetes and Chronic Kidney Disease: 2004–2013. Diabetes, Obesity and Metabolism. doi:10.1111/dom.12658.
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