Combined High-Dosage Drugs Shown to Ease Resistant OAB

Share this article:

Elderly patients with overactive bladder (OAB) that does not respond sufficiently to dose-escalated antimuscarinic monotherapy may benefit from combined high-dosage antimuscarinics, researchers reported online in the UroToday International Journal.

They studied 81 OAB patients older than 65 years who previously recxeived double-dose antimuscarin monotherapy with trospium. After at least six months of such treatment with no or short-lived symptom improvement, patients were treated with two antimuscarinics.

Significant improvements were seen at a six-week follow-up, with the average number of daily incontinence events declining from six to two, average maximum bladder capacity increasing from 177 to 356 mL, average reflex volume rising from 149 to 284 mL, and average detrusor compliance improving from 16 to 37 mL/cm H2O. 

Side effects were comparable to that of normal-dosed antimuscarinics.

Share this article:
You must be a registered member of RUN to post a comment.

More in News in Brief

Reasons for Alpha Blocker Switch ID'd

Reasons for Alpha Blocker Switch ID'd

Lack of efficacy is the main reason for the switch.

Urodynamic Studies On the Upswing

Urodynamic Studies On the Upswing

Urodynamic studies for female Medicare patients increased by 29% from 2000 to 2010.

FDA Okays Rapid-Acting Inhaled Insulin

FDA Okays Rapid-Acting Inhaled Insulin

Afrezza is administered at the start of each meal or within 20 minutes after starting a meal.