Neoadjuvant VEGF-Targeted Therapy in Renal Cell Carcinoma

Recent therapeutic advances in metastatic renal cell carcinoma (RCC) have included agents targeted against vascular endothelial growth factor (VEGF).

Bioartificial Kidney Meeting Research Milestones

A pioneering implantable artificial kidney developed jointly by teams of researchers at Cleveland Clinic, the University of California at San Francisco, and the University of Michigan in Ann Arbor is on track to meet project milestones in a pilot and feasibility study funded by the NIH.

Changes in the In-Hospital Dialysis Unit

The provision of in-hospital dialysis services over the next decade will necessitate a rethinking of the unit infrastructure.

Partial Nephrectomy for Larger Renal Masses

Partial nephrectomy has been the procedure of choice for patients with poor renal function, tumors in solitary kidneys or bilateral renal tumors.

How a 'Glomerulonephritis Board' Can Help Improve Patient Care

How a 'Glomerulonephritis Board' Can Help Improve Patient Care

Considering the advancement in the diagnosis and treatment of glomerular disease, we formed a Glomerulonephritis Board (GN Board) at Cleveland Clinic that brings together key medical specialists.

Optimal Use of the Electronic Medical Record in CKD

The electronic medical record (EMR) has enabled creation of a CKD registry, a database that contains demographic information, clinical parameters, and outcome measurements of more than 41,000 CKD patients who have received medical care within the Cleveland Clinic Health System since January 2005.

Redefining Hypertension for Tomorrow: Target Levels

There is sufficient evidence to demonstrate that lowering BP to less than 140/90 mm Hg offers cardiovascular and renal protection.

Magnetic Resonance Imaging of the Prostate

Prostate magnetic resonance (MR) provides high-resolution images of the prostate; seminal vesicles; and nearby pelvic organs and structures, including the bladder and rectum.

Kidney Function in Living Donors: Understanding Health Versus Disease

Data from 1,000 former kidney donors suggest that normal values of glomerular filtration rate decline with age.

First Completely Transvaginal Nephrectomy

First Completely Transvaginal Nephrectomy

Jihad Kaouk, MD, Director of the Center for Laparoscopic and Robotic Surgery, and his team performed the world's first completely transvaginal nephrectomy on March 13, 2009.

Effects of Smoke on Bladder Cancer Treatment

Last year, our lab team received a grant from the Flight Attendants Medical Research Institute (FAMRI). FAMRI was created from a settlement with tobacco companies over flight attendant exposure to secondhand smoke in their work.

Transobturator Sling for Post-Op Incontinence in Men

A urethral sling placed via a transobturator approach has recently emerged as a treatment option for men with mild-to-moderate postprostatectomy incontinence.

After the PSA Cutoff Era: The Importance of Context

About two years ago, having recognized that the prostate-specific antigen (PSA) cutoff level of 4.0 ng/mL did not always assist in accurately categorizing a man's risk for prostate cancer, we began to eliminate this—or any—artificial cutoff defining a "normal" PSA value.

Eric A. Klein, MD, Appointed Glickman Institute Chairman

Eric A. Klein, MD, Appointed Glickman Institute Chairman

Eric A. Klein, MD, a thought leader in the biology and management of prostate cancer, has been appointed chairman of the Glickman Urological & Kidney Institute.

Kidney Transplants in Nonrenal Solid-Organ Transplant Recipients

The number of candidates on the list for kidney transplantation due to end-stage renal disease after a prior nonrenal transplant, particularly liver transplant, is growing significantly.

Factors Influencing Response to ESAs

Researchers are examining the role of iron-regulatory proteins in patients with CKD-related anemia

Robotic Single-Port Surgery Proves Successful

Robotic Single-Port Surgery Proves Successful

It improves range of motion and motor precision in ergonomically challenging surgical cases

Treating Bladder Ca with Sunitinib

The medication is being tested as adjuvant therapy in patients with locally advanced urothelial cancer.

Stem Cell Homing for Stress Urinary Incontinence

Prevalence data suggest that during their lifetimes, up to half of U.S. women experience some level of female pelvic floor disorders (FPFD). However, despite the prevalence of FPFD, little is known about their pathophysiology.

STEP: A Novel Way to Treat Large Volume BPH

We recently reported our initial experience with single-port transvesical enucleation of the prostate (STEP) performed through a solitary suprapubic incision via a single-access port inserted directly into the bladder in three patients with symptomatic BPH.

Cell Phone Use By Men May Decrease Fertility

Cell Phone Use By Men May Decrease Fertility

Evidence from our latest study has demonstrated a cause-and-effect relationship between cell-phone usage and poor semen quality, recognized as a common cause for male factor infertility.

Focal Therapy for Low-Risk Prostate Cancer

Focal Therapy for Low-Risk Prostate Cancer

Although the traditional approach to prostate cancer has been to target the entire gland, Cleveland Clinic has offered focal cryotherapy on a very limited basis since 2005 for men with low-risk disease who understand the implications of all treatment options.

Investigators Studying New Biomarkers for Predicting Acute Kidney Failure

Development of postoperative acute renal failure (ARF) increases the mortality after cardiac surgery to 50%. Previous attempts at therapeutic interventions have failed, and the survival rate associated with ARF remains dismal.

Consortium Establishes Criteria for Single-Port Surgery

A multidisciplinary consortium of 28 surgeons from the United States and around the world convened for a one-day closed-door brainstorming meeting at Cleveland Clinic on July 7. The consortium's goal was to establish an approach to advance responsibly the rapidly growing field of single-portal laparoscopic surgery.

Single-Port Laparoscopic and Robotic Surgery

The recently developed single-port, multichannel access approach to urologic surgery may allow many common laparoscopic and robotic procedures to be performed entirely through the patient's umbilicus, enabling essentially scarless abdominal surgery. To date, Cleveland Clinic has performed 115 single-port laparoscopic procedures for various indications.

Artificial Kidney Could Replace Dialysis

Most patients with end-stage renal disease (ESRD) depend on hemodialysis and suffer excessive mortality and morbidity. Kidney failure is becoming an epidemic in the United States, fueled by diabetes, obesity and, paradoxically, improved cardiac care.

Shared Philosophy and Natural Partnership

A year and a half ago, Cleveland Clinic's Glickman Urological Institute and Nephrology Department joined to form the Glickman Urological & Kidney Institute. Merging urologists, nephrologists, kidney and pancreas transplant surgeons, hypertension specialists, dialysis physicians, and scientists into one group was part of an institution-wide movement at Cleveland Clinic that organized clinical areas around organ and disease systems rather than individual specialties.

1,000th LPN Performed

Surgeons at the Cleveland Clinic's Glickman Urological and Kidney Institute completed their 1,000th laparoscopic partial nephrectomy (LPN) on Aug.7, making their experience with the procedure the most extensive in the world.

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