CKD

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

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Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

Total Kidney Volume in ADPKD Predicts CKD Progression

Total Kidney Volume in ADPKD Predicts CKD Progression

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Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.

Some High-risk Heart Failure Patients Benefit From MRAs

Some High-risk Heart Failure Patients Benefit From MRAs

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Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

A fourth of adults with CKD of unknown cause, familial nephropathy, or hypertension have diagnosed mutations that can be identified using WES.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

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Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

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Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

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Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Pruritus in Hemodialysis Patients Underestimated, Undertreated

Pruritus in Hemodialysis Patients Underestimated, Undertreated

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Among hemodialysis patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for the condition.

Decreasing Kidney Function Increases Atrial Fibrillation Risk

Decreasing Kidney Function Increases Atrial Fibrillation Risk

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Atrial fibrillation risk increases as estimated glomerular filtration rate decreases and albuminuria increases, according to a new meta-analysis.

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

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Pilot study suggests intranasal theophylline may be worth further investigation as a treatment.

Proteomics Identifies CKD Predictors

Proteomics Identifies CKD Predictors

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The investigators assessed proteomic profiling of 80 proteins using a multiplex assay.

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

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Researchers used pulse wave analysis to measure subendocardial viability ratio, a measure of myocardial perfusion, and its association with hemoglobin.

CKD Linked to High Intake of Red, Processed Meat

CKD Linked to High Intake of Red, Processed Meat

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Chronic kidney disease stage 3 is 23% more likely to develop in individuals in the highest versus lowest quintile of consumption of red and processed meat.

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

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Study findings suggest that the medication may offer renal protection.

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

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In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.

Medications Contribute to Phosphate Intake

Medications Contribute to Phosphate Intake

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Among the phosphate-containing medicinal products prescribed to chronic kidney disease patients, 76% may contain absorbable phosphate.

Study: 30% Decline in eGFR Over 2 Years Strongly Predicts ESRD

Study: 30% Decline in eGFR Over 2 Years Strongly Predicts ESRD

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Baseline eGFR, higher phosphorus, proteinuria, and male gender, also are associated with an elevated risk of end-stage renal disease in patients with chronic kidney disease.

Drug Controls Hyperkalemia in Diabetic Kidney Disease

Drug Controls Hyperkalemia in Diabetic Kidney Disease

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Patiromer's efficacy and safety confirmed out to 52 weeks.

ECG Metrics May Predict Cardiac Deaths in CKD Patients

ECG Metrics May Predict Cardiac Deaths in CKD Patients

ECG Metrics are stronger as markers for cardiovascular death than for all-cause mortality or noncardiovascular death.

Kidney Failure Risk, Ammonia Excretion Linked

Kidney Failure Risk, Ammonia Excretion Linked

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Study implicates an inability of a CKD patient's kidneys to excrete the daily acid load.

Poorly Controlled Diabetes May Increase Dementia

Poorly Controlled Diabetes May Increase Dementia

Older patients with more diabetes complications have greater cognitive decline, study finds.

Chronic Kidney Disease Raises Fracture Risk in Children

Chronic Kidney Disease Raises Fracture Risk in Children

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Fracture rates are 2.4- to 3-fold higher than rates found in the general population of children and adolescents.

Chronic Kidney Disease Risk Higher in Female Diabetics

Chronic Kidney Disease Risk Higher in Female Diabetics

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In a study, CKD was 35% more likely to develop in female than male diabetics in adjusted analyses that took into account death as a competing risk.

Risk Factors for CKD Progression ID'd

Risk Factors for CKD Progression ID'd

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Proteinuria, hyperphosphatemia, anemia linked more rapid annual decline in eGFR.

CKD Model May Improve Care via Electronic Health Records

CKD Model May Improve Care via Electronic Health Records

CKD, which is mainly defined by laboratory abnormalities, is a suitable EHR phenotype.

Metformin Use in Advanced CKD Raises Death Risk

Metformin Use in Advanced CKD Raises Death Risk

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Study reveals a 35% increase in all-cause mortality risk compared with non-use.

Cholecalciferol May Be Superior for Treating Vitamin D Deficiency

Cholecalciferol May Be Superior for Treating Vitamin D Deficiency

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Treatment with this compound resulted in higher circulating levels of 25(OH)D compared with ergocalciferol in Hispanic CKD patients.

Dysfunctional HDL May Contribute to Excess CVD Risk in CKD Patients

Dysfunctional HDL May Contribute to Excess CVD Risk in CKD Patients

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After standard lipid treatments, CKD patients still have up to a 70% residual risk of cardiovascular disease.

Vitamin D May Slow CKD Progression in Children

Vitamin D May Slow CKD Progression in Children

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In a study, renal survival increased by 8.2% with each 10 nmol/L increment in baseline levels of 25-hydroxyvitamin D.

Many Beverages Contain Hidden Phosphorus

Many Beverages Contain Hidden Phosphorus

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A study found that 78% of popular drinks, from flavored waters to lemonades to iced teas, contain far more phosphorus than listed in nutritional databases.

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