Chronic Kidney Disease

Recommendations Issued for Tolvaptan Use in ADPKD

Recommendations Issued for Tolvaptan Use in ADPKD

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ERA-EDTA offers guidance on selecting patients for treatment, when to start the drug, dosing strategies, and other aspects of care.

Statin Use May Raise Kidney Disease Risk

Statin Use May Raise Kidney Disease Risk

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Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

Caution Urged In the Use of Megestrol

Caution Urged In the Use of Megestrol

Use of oral megestrol acetate (MA) is associate with significant adverse effects.

Study: Sleep Apnea May Be a CKD Risk Factor

Study: Sleep Apnea May Be a CKD Risk Factor

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Chronic kidney disease found to be 58% more likely to develop in individuals with than without the sleep disorder.

Tolvaptan Lowers ADPKD Albuminuria

Tolvaptan Lowers ADPKD Albuminuria

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New findings suggest the medication induces beneficial renal structural changes.

Statins Reduce Proteinuria, Mortality in CKD Patients

Statins Reduce Proteinuria, Mortality in CKD Patients

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The drugs do not appear to prevent progression to ESRD, new meta-analysis finds.

Aliskiren's Effects on Albuminuria May Be Too Small

Aliskiren's Effects on Albuminuria May Be Too Small

Overall albuminuria drop may be too small for cardiovascular, renal risk protection.

Very Low-Protein Diet With Ketoanalogue May Slow CKD Progression

Very Low-Protein Diet With Ketoanalogue May Slow CKD Progression

Four patients would need to adhere to diet to avoid primary end point in per-protocol analysis.

Earlier ESA Initiation May Improve Renal Outcomes

Earlier ESA Initiation May Improve Renal Outcomes

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Study shows benefit of initiating epoetin beta therapy at hemoglobin levels not less than 10 g/dL in non-dialysis CKD patients.

Cinacalcet for SHPT May Lower Testosterone

Cinacalcet for SHPT May Lower Testosterone

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Serum total and free testosterone declined in men on hemodialysis who received a 6-month course of the drug for secondary hyperparathyroidism.

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

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Treatment corrects anemia and improves quality of life, according to a systemic review.

Weight-based Insulin in Hyperkalemia Results in Less Hypoglycemia

Weight-based Insulin in Hyperkalemia Results in Less Hypoglycemia

Less hypoglycemia for patients weighing less than 95 kg, with no impact on potassium lowering.

Online Tool Helps Predict ESRD in CKD Patients

Online Tool Helps Predict ESRD in CKD Patients

New risk calculator estimates who will need dialysis in 2 to 5 years.

The Promise of the New Hyperkalemia Drugs

The Promise of the New Hyperkalemia Drugs

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Renal & Urology News interviewed Matthew R. Weir, MD, director of the division of nephrology and professor of medicine at the University of Maryland School of Medicine in Baltimore.

Proton Pump Inhibitors Linked to Increased Risk of CKD

Proton Pump Inhibitors Linked to Increased Risk of CKD

While study can't prove cause-and-effect, increasing damage seen as dose rises.

Heart Failure Mortality in U.S. Increased 2012-2014

Heart Failure Mortality in U.S. Increased 2012-2014

Decrease in age-adjusted death rates from 2000 to 2012; increase from 2012 to 2014.

CKD Risk Following Inpatient Acute Kidney Injury Characterized

CKD Risk Following Inpatient Acute Kidney Injury Characterized

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Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.

Greater Use of Mechanical Circulatory Support in PCI

Greater Use of Mechanical Circulatory Support in PCI

2004 to 2012 saw increase in percutaneous ventricular assist devices, intraaortic balloon pump.

Kidney Damage Linked to Prediabetes

Kidney Damage Linked to Prediabetes

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In a prospective study, prediabetes was an independent risk factor for hyperfiltration and increased albuminuria.

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

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Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients with no kidney disease.

Current eGFR Better for ESRD Prediction

Current eGFR Better for ESRD Prediction

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It has a stronger association with future end-stage renal disease risk than past eGFR decline, large study shows.

Worrisome Drug Interaction for Acenocoumarol, Levofloxacin

Worrisome Drug Interaction for Acenocoumarol, Levofloxacin

Probable interaction described in 5 patients, all of whom had atrial fibrillation.

No Increased Bleeding Risk With Warfarin in CKD Patients

No Increased Bleeding Risk With Warfarin in CKD Patients

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Direct oral anticoagulants were superior to dose-adjusted warfarin, however, reducing the risk of major bleeding by 19% in patients with mild to moderate renal impairment.

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

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In a study, investigators observed that levels were higher in those with stage 3a than stage 3b chronic kidney disease.

Central Venous Pressure-Guided Hydration May Reduce CIN

Central Venous Pressure-Guided Hydration May Reduce CIN

Reduced risk of contrast-induced nephropathy with no increase in acute heart failure.

Greater Plant Protein Intake May Lower Death Risk in CKD Patients

Greater Plant Protein Intake May Lower Death Risk in CKD Patients

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The death risk decreases 23% with each 33% increase in plant protein to total protein ratio, study finds.

Patiromer Benefits High-Risk Hyperkalemic Patients

Patiromer Benefits High-Risk Hyperkalemic Patients

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The medication significantly decreased potassium levels over 52 weeks in patients with resistant hypertension and diabetic kidney disease.

Newer Anticoagulants Safer for CKD Patients

Newer Anticoagulants Safer for CKD Patients

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Meta-analysis reveals a lower risk of bleeding and arterial thromboembolism compared with conventional agents.

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