Chronic Kidney Disease

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

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Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

Total Kidney Volume in ADPKD Predicts CKD Progression

Total Kidney Volume in ADPKD Predicts CKD Progression

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Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.

Some High-risk Heart Failure Patients Benefit From MRAs

Some High-risk Heart Failure Patients Benefit From MRAs

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Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

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Pretreating enteral nutrition formula with sodium polystyrene sulfonate lowers potassium levels in hyperkalemic children with chronic kidney disease, small study finds.

Antiretroviral Combo May Increase Kidney Disease Risk

Antiretroviral Combo May Increase Kidney Disease Risk

CKD occurrence was seen in 3.4% of HIV patients receiving the combination of medications.

Shift in HIV-Associated Kidney Disease Characterized

Shift in HIV-Associated Kidney Disease Characterized

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Antiretroviral therapies have prolonged the survival of HIV patients, but the drugs can have adverse effects on the kidneys.

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

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In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Urinary ceruloplamin has potential to be a chronic kidney disease biomarker for patients with sickle cell anemia.

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

A fourth of adults with CKD of unknown cause, familial nephropathy, or hypertension have diagnosed mutations that can be identified using WES.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

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Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Medication Discrepancies Common in Advanced CKD

Medication Discrepancies Common in Advanced CKD

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In a study, taking a medication not on a nephrologists' list, not taking a specified medication, taking different doses, or following a different frequency topped the list.

Lithium Therapy May Not Increase ESRD Risk

Lithium Therapy May Not Increase ESRD Risk

In the subcohorts of patients with a diagnosis of bipolar disorder, continuing lithium was associated with decreased end-stage CKD, whereas continuing anticonvulsants was not.

New Model Improves Predictions of Advanced CKD Following AKI

New Model Improves Predictions of Advanced CKD Following AKI

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The model was based on 6 variables readily obtained at hospital discharge.

Potential Target for Fibrillary Glomerulonephritis ID'd

Potential Target for Fibrillary Glomerulonephritis ID'd

Fibrillary glomerulonephritis glomeruli exhibit overexpression of DNAJB9 protein.

Sertraline Not Effective for Depression in CKD

Sertraline Not Effective for Depression in CKD

No improvement for patients with MDD and chronic kidney disease without dialysis dependence.

Proton Pump Inhibitor Use May Up CKD, ESRD

Proton Pump Inhibitor Use May Up CKD, ESRD

Risk for both chronic kidney disease, end-stage renal disease higher with proton pump inhibitor use.

Review Highlights Nutritional Management of CKD

Review Highlights Nutritional Management of CKD

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A low-protein diet, for example, may slow disease progression.

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

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Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

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Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

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Transcatheter aortic valve replacement increases the risk of requiring renal replacement therapy and the risk of death among patients with stage 4 or 5 CKD.

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

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Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Serum Uromodulin May Predict CKD Development

Serum Uromodulin May Predict CKD Development

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Uromodulin may be a novel predictive serum biomarker.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

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In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Air Pollution May Lead to CKD, ESRD

Air Pollution May Lead to CKD, ESRD

Study finds link between particulate matter and renal function.

Pruritus in Hemodialysis Patients Underestimated, Undertreated

Pruritus in Hemodialysis Patients Underestimated, Undertreated

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Among hemodialysis patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for the condition.

Sleep Duration, Quality Associated With CKD Progression

Sleep Duration, Quality Associated With CKD Progression

Short and poor quality sleep are unrecognized risk factors for CKD progression.

Chronic Kidney Disease Raises Tinnitus Risk

Chronic Kidney Disease Raises Tinnitus Risk

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Tinnitus is 3-fold more likely to develop in patients with versus without chronic kidney disease, new study shows.

Intensive BP Control May Reduce Death Risk in CKD Patients

Intensive BP Control May Reduce Death Risk in CKD Patients

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Targeting and treating systolic blood pressure to a lower range was associated with a 14% decreased risk of death, meta-analysis shows.

Chronic Kidney Disease Risk Higher With Intensive BP Control

Chronic Kidney Disease Risk Higher With Intensive BP Control

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Targeting a systolic blood pressure below 120 mm Hg versus 135 to 139 mm Hg increased the absolute risk of incident CKD by 2.6% over 3 years, but decreased the risk of cardiovascular events or death.

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