Chronic Kidney Disease

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

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Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Serum Uromodulin May Predict CKD Development

Serum Uromodulin May Predict CKD Development

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Uromodulin may be a novel predictive serum biomarker.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

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In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Air Pollution May Lead to CKD, ESRD

Air Pollution May Lead to CKD, ESRD

Study finds link between particulate matter and renal function.

Pruritus in Hemodialysis Patients Underestimated, Undertreated

Pruritus in Hemodialysis Patients Underestimated, Undertreated

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Among hemodialysis patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for the condition.

Sleep Duration, Quality Associated With CKD Progression

Sleep Duration, Quality Associated With CKD Progression

Short and poor quality sleep are unrecognized risk factors for CKD progression.

Chronic Kidney Disease Raises Tinnitus Risk

Chronic Kidney Disease Raises Tinnitus Risk

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Tinnitus is 3-fold more likely to develop in patients with versus without chronic kidney disease, new study shows.

Intensive BP Control May Reduce Death Risk in CKD Patients

Intensive BP Control May Reduce Death Risk in CKD Patients

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Targeting and treating systolic blood pressure to a lower range was associated with a 14% decreased risk of death, meta-analysis shows.

Chronic Kidney Disease Risk Higher With Intensive BP Control

Chronic Kidney Disease Risk Higher With Intensive BP Control

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Targeting a systolic blood pressure below 120 mm Hg versus 135 to 139 mm Hg increased the absolute risk of incident CKD by 2.6% over 3 years, but decreased the risk of cardiovascular events or death.

Retinal Emboli Associated With CVD Risk Factors, Stroke, CKD

Retinal Emboli Associated With CVD Risk Factors, Stroke, CKD

Older age, Indian ethnicity, hypertension, chronic kidney disease, creatinine level, glomerular filtration rate, and history of stroke were associated with prevalent retinal emboli in multivariable-adjusted analysis.

Metoprolol Increases Uric Acid, Risk of Gout

Metoprolol Increases Uric Acid, Risk of Gout

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In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.

Study Finds No Link Between Marijuana Use and Kidney Function

Study Finds No Link Between Marijuana Use and Kidney Function

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No significant association found between marijuana use and change in estimated glomerular filtration rate or development of albuminuria.

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

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Bosutinib treatment was associated with a 66% decrease in the annual rate of kidney enlargement.

Infection Risk Increases as Kidney Function Declines

Infection Risk Increases as Kidney Function Declines

Lower respiratory tract infections, urinary tract infections, and sepsis made up a larger proportion of infections as kidney function worsened.

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

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Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.

Glomerular Disease Differs Globally

Glomerular Disease Differs Globally

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International survey finds geographic variation in the subtype frequencies in biopsied patients.

Decreasing Kidney Function Increases Atrial Fibrillation Risk

Decreasing Kidney Function Increases Atrial Fibrillation Risk

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Atrial fibrillation risk increases as estimated glomerular filtration rate decreases and albuminuria increases, according to a new meta-analysis.

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

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Pilot study suggests intranasal theophylline may be worth further investigation as a treatment.

Methylprednisolone Tied With Serious Adverse Events in IgA Nephropathy

Methylprednisolone Tied With Serious Adverse Events in IgA Nephropathy

The researchers found that serious events occurred in 14.7% and 3.2% of participants in the methylprednisolone and placebo groups, respectively, mainly due to excess serious infections.

Proteomics Identifies CKD Predictors

Proteomics Identifies CKD Predictors

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The investigators assessed proteomic profiling of 80 proteins using a multiplex assay.

Increased Mortality in CKD Pts With Impaired LV Global Longitudinal Strain

Increased Mortality in CKD Pts With Impaired LV Global Longitudinal Strain

After adjustment for age, gender, albumin levels, atrial fibrillation, and renal transplantation, LV GLS ≤10.6% was significantly associated with increased risk of all-cause mortality.

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

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Researchers used pulse wave analysis to measure subendocardial viability ratio, a measure of myocardial perfusion, and its association with hemoglobin.

suPAR May Trigger CKD, Renal Decline in <i>APOL1</i> Variant Pts

suPAR May Trigger CKD, Renal Decline in APOL1 Variant Pts

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.

Intensive Blood Pressure Reduction Benefits CKD Patients

Intensive Blood Pressure Reduction Benefits CKD Patients

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CKD patients treated to a target systolic blood pressure of less than 120 mm Hg were 28% less likely to die early.

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

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Anemic patients were 41% and 80% more likely to have coronary artery disease and peripheral artery disease than non-anemic patients.

CKD Linked to High Intake of Red, Processed Meat

CKD Linked to High Intake of Red, Processed Meat

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Chronic kidney disease stage 3 is 23% more likely to develop in individuals in the highest versus lowest quintile of consumption of red and processed meat.

1 in 7 Americans Has CKD and Most Unaware

1 in 7 Americans Has CKD and Most Unaware

The researchers said rising rates of diabetes and hypertension may help explain the increase in kidney disease, along with several other factors.

Nephrology Referrals May Not Benefit Elderly CKD Patients

Nephrology Referrals May Not Benefit Elderly CKD Patients

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Most elderly CKD patients ultimately will not require or desire renal replacement therapy.

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

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In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.

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