Renal Artery Embolization May Ease ADPKD Symptoms
In a small study, researchers performed the procedure using N-butyl cyanoacrylate.
SAN DIEGO—Reducing renal volume using a renal artery embolization technique is feasible and effective for treating symptomatic autosomal dominant polycystic kidney disease (ADPKD), Japanese researchers concluded in a report presented at the Society for Interventional Radiology annual meeting suggest.
Rie Yoshida, MD, of Kansai Medical University Hirakata Hospital in Hirakata City, Osaka, and colleagues studied 5 ADPKD patients (4 women and 1 man) who underwent renal artery embolization using a mixture of N-butyl cyanoacrylate (NBCA) and iodized oil with low density.
All patients had severe refractory symptoms secondary to enlarged kidneys after initiation of dialysis. Bilateral and unilateral renal artery embolization was performed in 4 patients and 1 patient, respectively. Angiography was performed to confirm complete occlusion of the entire renal artery. Among nine kidneys, renal volume reduction was evaluated using computed tomography at 1, 3, 6, and 12 months after treatment.
Results showed that the technical and clinical success was 100%. None of the patients underwent another renal artery embolization procedure or additional volume reduction therapy. One patient had a hematoma at the puncture site. Symptoms decreased markedly in all patients and did not recur.
The mean basal renal volume before embolization was 2,222 cm3. The mean volume reduction rates were 83.0%, 65.5%, and 62.9% at 1, 3, and 6 months, respectively. At 12 months, the mean volume was 1,411 cm3 and the volume reduction rate was 50.9%, which was statistically significant.
“Transcatheter renal artery embolization with NBCA for symptomatic ADPKD is a feasible and effective procedure that offers relief of symptoms as well as renal volume reduction,” the authors concluded in their study abstract.