Paricalcitol Cuts Protein Excretion
Paricalcitol treatment is associated with a significant reduction in protein excretion in patients with proteinuric renal disease, according to researchers.
Steven Fishbane, MD, and colleagues at Winthrop-University Hospital, Mineola, N.Y., studied 61 patients with an estimated glomerular filtration rate (eGFR) of 15-90 mL/min/1.73 m2 and protein excretion greater than 400 mg/day. They randomly assigned subjects to receive six months of paricalcitol at a dosage of 1 μg/day or placebo.
At baseline, mean urinary protein to creatinine ratios were 2.8 and 2.6 g/g in the paricalcitol and placebo groups, respectively. At the final study evaluation (six months for those completing the study), the mean ratios were 2.3 and 2.7, respectively.
Protein excretion from baseline to final evaluation rose declined by 17.6% in the paricalcitol group and rose by 2.9% in the placebo arm, a significant between-group difference, the investigators reported in the American Journal of Kidney Diseases (2009; published online ahead of print). In addition, significant more paricalcitol-treated patients than placebo recipients had a 10% decrease in proteinuria (57.1% vs. 25.9%).