High Fiber Intake May Lower Inflammation Risk

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NASHVILLE—Increased fiber intake is associated with a lower risk of inflammation in both the CKD and non-CKD populations, data suggest.

Jennifer Zitterkoph, RD, and colleagues at the University of Utah in Salt Lake City, analyzed data obtained from 1,103 CKD and 14,874 non-CKD participants in the National Health and Nutrition Examination Survey III (NHANES III).

The investigators defined CKD as a glomerular filtration rate below 60 mL/min/1.73 m2 as determined using the Modified Diet in Renal Disease study formula and defined inflammation as a C-reactive protein (CRP) level greater than 3 mg/L. The researchers estimated dietary fiber intake from a 24-hour dietary recall interview conducted by trained personnel and divided fiber intake into tertiles: less than 10.5, 10.5-17.3, and more than 17.3 g/day.

Among CKD subjects, 51%, 46%, and 37% of those in the lowest, middle, and highest tertiles, respectively, had inflammation. Among non-CKD subjects, the proportions were 29%, 25%, and 20%, respectively, the researchers reported here at the National Kidney Foundation's 2009 Spring Clinical Meetings.

Compared with CKD subjects in the highest tertile, those in the lowest tertile had a twofold greater risk of inflammation. In the non-CKD group, those in the lowest tertile had a 38% increased risk compared with subjects in the highest tertile.

“Interventional trials are needed to determine whether high dietary fiber intake results in decreased cardiovascular events and mortality in the CKD population,” the authors wrote.

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