Gout Prevalent in German CKD Cohort
the Renal and Urology News take:
Gout is fairly common among chronic kidney disease (CKD) patients, a recent analysis of the German Chronic Kidney Disease study suggests.
Investigators evaluated data from more than 5,000 CKD patients and identified gout in 24.3%, according to results published in Nephrology Dialysis Transplantation. As kidney function decreased, gout prevalence increased, from 16% among patients with eGFR above 60 mL/min/1.73 m2 (with proteinuria) to 36% among those with eGFR below 30.
Roughly a third of patients with gout were not taking any medication for treatment at the time of the analysis. In addition, half of gout patients on urate-lowering therapy still showed signs of hyperuricemia. “Pharmacological management of gout in patients with CKD is suboptimal,” the investigators suggested.
The following factors were linked with gout: serum urate, lower eGFR, older age, male sex, higher BMI and waist-to-hip ratio, higher triglyceride and C-reactive protein (CRP) concentrations, alcohol intake, and diuretics use.
The researchers hope to assess whether gout and hyperuricemia increase the risk of CKD progression and cardiovascular events with future follow-up of this cohort.
About a quarter of the German Chronic Kidney Disease study participants reported gout.
Methods Data from 5085 CKD patients aged 18–74 years with an estimated glomerular filtration rate (eGFR) of 30–<60 mL/min/1.73 m2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values…
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