Gout Prevalent in German CKD Cohort

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Gout is fairly common among chronic kidney disease (CKD) patients, a recent analysis of the German Chronic Kidney Disease study suggests. 

Investigators evaluated data from more than 5,000 CKD patients and identified gout in 24.3%, according to results published in Nephrology Dialysis Transplantation. As kidney function decreased, gout prevalence increased, from 16% among patients with eGFR above 60 mL/min/1.73 m2 (with proteinuria) to 36% among those with eGFR below 30. 

Roughly a third of patients with gout were not taking any medication for treatment at the time of the analysis. In addition, half of gout patients on urate-lowering therapy still showed signs of hyperuricemia. “Pharmacological management of gout in patients with CKD is suboptimal,” the investigators suggested. 

The following factors were linked with gout: serum urate, lower eGFR, older age, male sex, higher BMI and waist-to-hip ratio, higher triglyceride and C-reactive protein (CRP) concentrations, alcohol intake, and diuretics use. 

The researchers hope to assess whether gout and hyperuricemia increase the risk of CKD progression and cardiovascular events with future follow-up of this cohort.

Gout Prevalent in German CKD Cohort
About a quarter of the German Chronic Kidney Disease study participants reported gout.
Background Reduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout is available from studies of patients with chronic kidney disease (CKD). We therefore examined the prevalence and correlates of gout in the large prospective observational German Chronic Kidney Disease (GCKD) study. 

Methods Data from 5085 CKD patients aged 18–74 years with an estimated glomerular filtration rate (eGFR) of 30–<60 mL/min/1.73 m2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values…

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