Diabetic Foot Linked to GFR

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As diabetic patients' renal function decreases, their risk of diabetic foot syndrome (DFS) increases, a study finds.

Each 10 mL/min decrease in estimated glomerular filtration rate (eGFR) was associated with a 30% increased risk of DFS in type 1 diabetes patients and a 13% increased risk in type 2 diabetes patients, according to a report in Nephrology Dialysis Transplantation (2009;24:1896-1901).  

“Diabetic patients with CKD should be considered as a high-risk group for the development of DFS and should therefore be regularly screened for DFS during every office visit,” the researchers wrote.

Gunter Wolf, MD, and his colleagues at the University of Jena in Jena, Germany, studied 899 patients with type 1 diabetes and 4,007 with type 2 diabetes. Forty-six of the type 1 patients (5.1%) and 532 of the type 2 patients (13.2%) had DFS.

Among type 1 patients, those with DFS had significantly higher serum creatinine levels, lower eGFR, higher hemoglobinA1c (HbA1c) levels, and higher systolic BP than those without DFS. Among the type 2 patients, those with DFS were significantly older, had a higher HbA1c, a longer duration of diabetes, a lower eGFR, and higher serum creatinine levels compared with those without DFS.

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