Contrast Nephropathy Associated with Long-Term Mortality in CKD

Increased long-term mortality risk for patients with, but not those without, CKD.
Increased long-term mortality risk for patients with, but not those without, CKD.

Contrast-induced nephropathy (CIN) is associated with long-term mortality in patients with, but not those without, chronic kidney disease (CKD), according to a study published in The American Journal of Cardiology (2014;114:362-368).

Mitsuru Abe, MD, from the National Hospital Organization Kyoto Medical Center in Japan, and colleagues examined the effect of CIN on long-term mortality after percutaneous coronary intervention in patients with or without CKD. Data were included for 4,371 patients who had paired serum creatinine measurements before and after percutaneous coronary intervention.

The researchers found that the incidence of CIN was 5% in the study cohort overall, and 11% in patients with CKD and 2% in those without CKD. A total of 8.6% of patients died during a median follow-up of 42.3 months after discharge. After adjusting for confounders, CIN was associated with a significant 2.3 times increased risk of long-term mortality in the entire cohort. In addition, CIN was associated with a significant 2.6 times increased risk of long-term mortality in patients with CKD but a non-significant 23% increased risk patients without CKD.

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