suPAR May Trigger CKD, Renal Decline in APOL1 Variant Pts

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The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.
The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.

(HealthDay News) — Plasma suPAR levels independently predict renal function decline in individuals with apolipoprotein L1 (APOL1) risk variants, according to a study published online in Nature Medicine.

Researchers gathered data from two separate cohorts of black patients: 487 people from the Emory Cardiovascular Biobank and 607 from the multi-center African American Study of Kidney Disease and Hypertension. Fifteen and 24% of the cohorts, respectively, had high-risk APOL1 genotypes.

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.

"What we are learning today is that suPAR in a general way is to kidneys what cholesterol is to the heart," senior author Jochen Reiser, MD, PhD, chair of the internal medicine department at the Rush University Medical Center in Chicago, said in a university news release.

Reference

  1. Hayek SS, Koh KH, Grams M, et al. A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. Nat Med. 26 June 2017. doi: 10.1038/nm.4362
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