Chronic Kidney Disease Impairs Digestive Function
CKD associated with dysmotility and reduces fasting and post-prandial small bowel water.
(HealthDay News) -- Chronic kidney disease (CKD) has an adverse effect on digestive function, according to a study published online in the Journal of Gastroenterology and Hepatology.
Claire J. Grant, from the Lilibeth Caberto Kidney Clinical Research Unit in London, Canada, and colleagues conducted detailed gastrointestinal magnetic resonance imaging in fasted and fed states among 35 subjects without diabetes (12 with CKD stage 4/5 and 23 healthy controls). The authors assessed upper gastrointestinal function by quantification of gastric emptying and intra-luminal small bowel water.
The researchers observed correlations for CKD with dysmotility (P = .04) and reduced fasting and post-prandial small bowel water (P < .001), indicating abnormal digestive secretion and absorption. There was a correlation with the degree of endotoxemia (P =.04) and poorer symptom scores. No correlation was found with disease severity, arterial stiffness, or hydration status.
"CKD adversely affects digestive function," the authors write. "Abnormalities in digestive secretion and absorption may potentially have a broad impact in the prevention and treatment of both CKD and its complications."
The study was funded by Baxter Healthcare.
1. Grant CJ, Harrison LE, Hoad CL, et al. Patients with CKD have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy. Journal of Gastroenterology and Hepatology. doi: 10.1111/jgh.13458.