Total Kidney Volume in ADPKD Predicts CKD Progression

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Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.
Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.

Baseline total kidney volume and rate of kidney growth in patients with autosomal dominant polycystic kidney disease (ADPKD) are strongly associated with the development of advanced stages of chronic kidney disease (CKD), researchers concluded in a report published online ahead of print in Kidney International.

In an extended study of ADPKD patients in the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study, Alan S. L. Yu, MB, of the University of Kansas Medical Center in Kansas City, and colleagues found that baseline height-adjusted total kidney volume (htTKV) is a strong independent predictor for the development of CKD after a median follow-up of 13 years. Each 100 mL/m increment in baseline htTKV was associated with a significant 38% and 42% increased odds for stage 3 and 4 CKD, respectively, and 35% increased odds of stage 5 CKD or end-stage renal disease. The rate of change in htTKV was negatively correlated with the slope of the glomerular filtration rate.

“These findings support the use of total kidney volume as a prognostic and potentially monitoring biomarke4r in ADPKD,” the authors concluded.

Reference

Yu ASL, Shen C, Landsittel DP, et al. Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in autosomal dominant polycystic kidney disease. Kidney Int. 2017; published online ahead of print.

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