Choice of First-Line Targeted Therapy Agent for Metastatic Clear Cell RCC

A 55-year-old woman in excellent overall health was diagnosed with a13 cm left renal mass extending into the left renal vein and concomitant low volume pulmonary metastases. She underwent an uneventful cytoreductive left radical nephrectomy.

Pathology reveals Fuhrman Grade 3 clear cell renal cell carcinoma. Repeat imaging demonstrates rapid disease progression with worsening thoracic metastatic disease and new asymptomatic bony metastases.

The ...