Macrolide Antibiotics Not Tied to Ventricular Arrhythmia
Study shows lower all-cause mortality in adults prescribed macrolide antibiotics.
HealthDay News — For older adults, macrolide antibiotics are not associated with a higher risk of ventricular arrhythmia within 30 days compared with nonmacrolide antibiotics, according to a study published online in CMAJ, the journal of the Canadian Medical Association.
Mai H. Trac, from Western University in London, Canada, and colleagues conducted a population-based retrospective cohort study involving adults aged older than 65 years with a new prescription for an oral macrolide antibiotic in Ontario, Canada, from 2002 to 2013. Using propensity scores, patients weracrolide antibiotics were not associated with a higher risk of ventricular arrhythmia e matched in a 1:1 ratio to controls prescribed nonmacrolide antibiotics. The analyses were repeated in 4 subgroups defined by the presence or absence of chronic kidney disease, congestive heart failure, coronary artery disease, and concurrent use of a drug known to prolong QT interval.
The researchers found that mcompared with nonmacrolide antibiotics (0.03 versus 0.03%; relative risk, 1.06; 95% confidence interval, 0.83 to 1.36). However, macrolide antibiotics were associated with a lower risk of 30-day all-cause mortality (0.62 versus 0.76%; relative risk, 0.82; 95% confidence interval, 0.78 to 0.86). Similar correlations were seen in all subgroups.
"These findings suggest that current warnings from the U.S. Food and Drug Administration may be overstated," the authors write.
One author's institution received unrestricted research funding from Pfizer.
- Trac MH, McArthur E, Jandoc R, et al. Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. Can Med Assoc J. 2016; doi: 10.1503/cmaj.150901