Lower Beta-Blocker Dose May Boost Survival After Heart Attack

Dosage should be tailored to the needs of individual patients, researchers say.
Dosage should be tailored to the needs of individual patients, researchers say.

(HealthDay News) -- Patients treated with low-dose beta-blockers after myocardial infarction may fare better than those given the standard dose, according to a study published in the Journal of the American College of Cardiology.

Jeffrey Goldberger, M.D., M.B.A., professor of medicine at the Northwestern University Feinberg School of Medicine and a cardiologist at Northwestern Memorial Hospital, and colleagues analyzed information on 6,682 myocardial infarction patients. Ninety percent of them were prescribed a beta-blocker.

Every patient on a beta-blocker lived longer than those who were not given this medication, the investigators found. Among those who received a full dose, 14.7% died within 2 years, compared with 12.9% who got a half-dose of the drug. Meanwhile, 9.5% of the patients on a quarter-dose and 11.5% of those on a one-eighth-dose died during this time period.

"We now need to figure out how to dose it in individual patients. That's something no one has considered in the decades that we have been using this medication," Goldberger said in a university news release. "This huge gap in knowledge has been completely unexplored. Since this is medicine we use in every single heart attack patient, we ought to figure out how to use it properly."

Sources

  1. Goldberger, JJ; Bonow, RO; Cuffe, M; et al. J Am Coll Cardiol. 2015;66(13):1431-1441; doi: 10.1016/j.jacc.2015.07.047.
  2. Taqueti, VR; O'Gara, PT; J Am Coll Cardiol. 2015;66(13):1442-1444; doi: 10.1016/j.jacc.2015.08.007.
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