Deceased-Donor Age Affects Kidney Transplant Outcomes
Recipients of kidneys from individuals who donated the organs after cardiac death are more likely to experience graft loss and delayed graft function.
Recipients of kidneys donated after cardiac death by individuals older than 50 years are more likely to experience graft loss and delayed graft function, researchers reported at the Canadian Urological Association 2016 annual meeting in Vancouver.
David M. Mikhail, MD, and collaborators at Western University in London, Ontario, studied transplant outcomes involving 6,800 cardiac-death donors. The group included 1,832 donors older than 50 years and 4,968 donors younger than 50 years. The mean donor ages were 55 and 31 years, respectively, and mean recipient ages were 56 and 50 years, respectively. The median Kidney Donor Profile Index was 37% and 74% for donors younger and older than 50 years, respectively. These values predicted 1, 3, and 5-year graft survival rates of 91%, 82%, and 71% among recipients of kidneys from the under-50 donors and 86%, 73%, and 60%, respectively, among recipients of kidneys from the over-50 donors. The delayed graft function rate (DGF) was significantly higher among recipients of kidneys from the over-50 donor group (49% vs. 37%). In both groups, DGF correlated with worse graft survival.
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