Bone Disease

Osteoporosis Drugs Up Bone Mineral Density in Nonmetastatic PCa

Osteoporosis Drugs Up Bone Mineral Density in Nonmetastatic PCa

Improvement in BMD was seen with denosumab, which also reduced the incidence of new radiographic vertebral fractures in one high-quality trial.

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

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Bone mineral density in the lumbar spine and femoral neck increased over time in hemodialysis patients who underwent total parathyroidectomy without autotransplantation.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

Guidelines for CKD Mineral and Bone Disorder Updated

Guidelines for CKD Mineral and Bone Disorder Updated

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Among other changes, the new KDIGO guidelines highlight the potential dangers of hypercalcemia.

Post-Parathyroidectomy Bone Changes in HD Patients Characterized

Post-Parathyroidectomy Bone Changes in HD Patients Characterized

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Researchers using spectral computed tomography found that calcium concentration increased in cortical bone and decreased in cancellous bone.

Study Finds New Clues to CKD Mineral Bone Disease

Study Finds New Clues to CKD Mineral Bone Disease

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Bone expression of sclerostin and parathyroid hormone receptor-1 increased in earlier stages of CKD, whereas FGF-23 and phosphorylated b-catenin showed increased expression in later stages.

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

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Alkaline phosphatase was more strongly linked to mortality compared with other biomarkers of chronic kidney disease-mineral and bone disorder.

Bone Metastases Seldom Progress During Radium-223 Therapy

Bone Metastases Seldom Progress During Radium-223 Therapy

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At 6 months of treatment, bone imaging showed stable disease in 94% of patients with available data, study finds.

Anemia, Bone Density Improve With Testosterone Replacement

Anemia, Bone Density Improve With Testosterone Replacement

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Older men on TRT versus placebo for 1 year had improved hemoglobin levels and volumetric bone mineral density and estimated bone strength.

Vitamin D Status Linked to Body Fat in Older Women

Vitamin D Status Linked to Body Fat in Older Women

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Adipose tissue may be more important than vitamin D intake, new study suggests.

Bone Mass Increases After Total Parathyroidectomy

Bone Mass Increases After Total Parathyroidectomy

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In a study, 94.1% of total PTx patients had improvement of bone mineral density at their most affected site.

Fewer Post-Transplant Fractures With Practice Changes

Fewer Post-Transplant Fractures With Practice Changes

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Fracture incidence within a year of transplant was 3 times lower among patients who had surgery from 2009 to 2011 vs 2004 to 2006.

Natural Vitamin D Supplement Effective for Nondialysis CKD-MBD

Natural Vitamin D Supplement Effective for Nondialysis CKD-MBD

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Over 33 months, the 25-hydroxyvitamin D level of ergocalciferol recipients increased significantly from 15.14 to 37.32 ng/mL.

Erectile Dysfunction Predicts Higher Risk of Osteoporosis

Erectile Dysfunction Predicts Higher Risk of Osteoporosis

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Low testosterone levels may be a contributing factor.

Loop Diuretics May Increase SHPT Risk in Non-Dialysis CKD

Loop Diuretics May Increase SHPT Risk in Non-Dialysis CKD

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SHPT risk was 4 times higher among patients taking furosemide vs hydrochlorothiazide.

Why SHPT Remains Difficult to Treat

Why SHPT Remains Difficult to Treat

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The control of phosphorus is underappreciated, for example.

ED Patients at Higher Risk of Hip Fracture

ED Patients at Higher Risk of Hip Fracture

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Almost quadruple the risk found among Asian men with erectile dysfunction.

Novel Approaches to Using Radium-223

Novel Approaches to Using Radium-223

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An interview with Neal Shore, MD

SHPT Risk Linked to eGFR in Children With Chronic Kidney Disease

SHPT Risk Linked to eGFR in Children With Chronic Kidney Disease

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High intact parathyroid hormone levels were associated with a lower estimated glomerular filtration rate.

CKD Severity Linked to Low BMD, Hip Fracture, and Mortality

CKD Severity Linked to Low BMD, Hip Fracture, and Mortality

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The risk of dying following a hip fracture was 6.5 times higher for patients with severe CKD than for those with normal kidney function or mild CKD.

Bisphosphonates May Protect Bone Density of Diabetic Women

Bisphosphonates May Protect Bone Density of Diabetic Women

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Fracture risk may be lower with bisphosphonates in women with diabetes.

Restricting Dietary Protein and Phosphorus May Improve CKD-MBD

Restricting Dietary Protein and Phosphorus May Improve CKD-MBD

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Very low protein intake was not superior to traditional low protein diets, however.

Extra Calcium from Diet, Supplements May Not Protect Bones

Extra Calcium from Diet, Supplements May Not Protect Bones

Researchers find no evidence that increasing calcium intake will prevent fractures.

Phosphorus-Based Food Additives May Impact Bone Metabolism

Phosphorus-Based Food Additives May Impact Bone Metabolism

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Even healthy adults show evidence of abnormal bone metabolism.

Low Sodium Raises Risk of Fracture

Low Sodium Raises Risk of Fracture

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Hyponatremia is a risk factor for osteoporosis and fracture, a new study confirms.

Abnormal Mineral, Bone Markers in Dialysis Patients Hike Mortality

Abnormal Mineral, Bone Markers in Dialysis Patients Hike Mortality

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Large European study identifies ranges of phosphorus, calcium, and parathyroid hormone levels with the lowest death risk.

More Than 1 in 6 Seniors Have Osteoporosis, CDC Says

More Than 1 in 6 Seniors Have Osteoporosis, CDC Says

Prevalence of osteoporosis 16.2% in adults aged 65 years and older; higher among women.

Resistance Exercises Can Improve Men's Bone Health

Resistance Exercises Can Improve Men's Bone Health

Findings for weight-lifting, jump training in middle-aged men with osteopenia.

Vitamin D Supplements May Not Improve Bone Health

Vitamin D Supplements May Not Improve Bone Health

No increases seen in bone density, muscle mass, or mobility in postmenopausal women.

Daily Fruits and Vegetables Linked to Reduced Hip Fracture

Daily Fruits and Vegetables Linked to Reduced Hip Fracture

Dose-response association noted with increased fracture rates for fruit and vegetable intake below 5 servings/day.

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