Bladder Cancer

Bladder Cancer Risk Higher in Urinary Stone Formers

Bladder Cancer Risk Higher in Urinary Stone Formers

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Patients with versus without a history of urinary calculi had nearly 2-fold greater odds of bladder cancer, meta-analysis showed.

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

40% of active surveillance events were deemed to require treatment.

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

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Chemoradiation for muscle-invasive bladder cancer is associated with a lower 1-year mortality risk versus radical cystectomy, but at year 2 and beyond, mortality risk is lower with radical cystectomy.

Quit Smoking Medications Not Found Effective

Quit Smoking Medications Not Found Effective

No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence.

Few Immuno-Oncology Agents Effective by ASCO Standards

Few Immuno-Oncology Agents Effective by ASCO Standards

Durable survival, response rates rarely recognized as significant by current oncology value frameworks.

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy.

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

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The proportion of patients who received neoadjuvant chemotherapy for muscle-invasive bladder cancer prior to cystectomy rose from 4% to 27% of patients from 1994 to 2013.

Preop Aerobic Exercise May Improve Cystectomy Outcomes

Preop Aerobic Exercise May Improve Cystectomy Outcomes

A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

About 45.1% of cancer deaths and 42% of all incident cancers are linked to modifiable risk factors.

Trimodal Therapy and RC for MIBC Offer Similar Survival

Trimodal Therapy and RC for MIBC Offer Similar Survival

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Mean disease-specific survival at 10 years was 50.9% for TMT and 57.8% for RC patients, a non-significant difference.

Urinary Arsenic Falling in Public Water Consumers

Urinary Arsenic Falling in Public Water Consumers

Reduction occurred after implementation of EPA's maximum contaminant level for arsenic

Fewer Cancer Patients Are Asked to Quit Smoking

Fewer Cancer Patients Are Asked to Quit Smoking

General practitioners less likely to support smoking cessation in patients with cancer than with CHD

Photocure Seeks Expanded Use of Blue Light Cystoscopy

Photocure Seeks Expanded Use of Blue Light Cystoscopy

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FDA has accepted a supplemental New Drug Application asking to expand the labeling indication for Cysview to include use the bladder cancer-detecting system in the outpatient setting.

COBRA Score Gauges Mortality Risk After Cystectomy

COBRA Score Gauges Mortality Risk After Cystectomy

Tool incorporates the relative contribution of tumor stage, lymph node involvement.

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Patients with high alteration number in variants of unknown significance had better outcomes.

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Patients on combination therapy have increased risk of thyroid dysfunction and hypophysitis.

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

The researchers note that TACC3 is a mitotic spindle protein required for accurate segregation of chromosomes, and errors in segregation can lead to aneuploidy, contributing to cancer progression.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

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Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively.

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

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Radical cystectomy is associated with better survival, but findings suggest BPT may produce acceptable oncologic outcomes in appropriately selected patients.

Enhanced Cystoscopy Improves the Care of Bladder Cancer Patients

Enhanced Cystoscopy Improves the Care of Bladder Cancer Patients

The guidelines state that clinicians should offer blue light cystoscopy, if available, as an adjunct to traditional white light cystoscopy (WLC) to increase tumor detection and decrease recurrence.

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

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Instilling mitomycin C within 24 hours of TURBT vs after 2 weeks was associated with a 27% lower risk of recurrence.

Study: Cystectomy Complication Rate Not Improving

Study: Cystectomy Complication Rate Not Improving

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Researchers find no significant change in overall complication rate from 2010 to 2015, but hospital length of stay and need for transfusion have declined.

TERT Test May Improve Detection of Bladder Cancer Recurrence

TERT Test May Improve Detection of Bladder Cancer Recurrence

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In a study, a positive test result was associated with a 5-fold increased risk of recurrent non-muscle invasive bladder cancer.

Robotic, Open Radical Cystectomy Offer Similar Results

Robotic, Open Radical Cystectomy Offer Similar Results

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A new review shows no significant differences in oncologic outcomes, long-term complications, and health-related quality of life between robot-assisted and open radical cystectomy.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

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Symptomatic recurrence was associated with a nearly 2-fold higher risk of death from the time of recurrence versus surveillance-detected recurrence.

Surgery, Combined Modality Offer Similar MIBC Outcomes

Surgery, Combined Modality Offer Similar MIBC Outcomes

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Meta-analysis reveals no significant difference in overall-, disease-specific, and progression-free survival between radical cystectomy and radiation-based, bladder preservation therapy.

MIBC Patients Should Be Followed Long-term After Cystectomy

MIBC Patients Should Be Followed Long-term After Cystectomy

After recurrent disease, 5-year overall survival was worse among patients with late recurrence.

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