Bladder Cancer

Urinary Cytology and Biomarkers in NMIBC: What's New?

Urinary Cytology and Biomarkers in NMIBC: What's New?

Cystoscopy and cytology remain the standard for diagnosis, but a plethora of urinary biomarkers could someday be a useful adjunct to NMIBC surveillance.

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

One-year overall survival of 61% for gemcitabine and cisplatin plus ipilimumab.

Non-Invasive Test for Urothelial Cancer Detection

Non-Invasive Test for Urothelial Cancer Detection

When combined with cytology, UroSEEK detected 95% of patients who developed bladder cancer

Bladder Cancer Mortality in Men Lower With 5-ARI Use

Bladder Cancer Mortality in Men Lower With 5-ARI Use

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Use of 5-alpha-reductase inhibitors before and after diagnosis of the malignancy is associated with a 15% and 22% decreased risk of bladder cancer mortality, respectively.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

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In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model, based on 6 factors, predicts overall survival for patients treated with atezolizumab

Active Surveillance Reasonable for NMIBC

Active Surveillance Reasonable for NMIBC

Appears to be a cost-effective strategy for patients with small size, stage pTa or pT1a recurrent tumors

Atezolizumab Safe, Beneficial Long-Term in mUC

Atezolizumab Safe, Beneficial Long-Term in mUC

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In a 3-year study, toxic effects of atezolizumab remained manageable and responses durable.

Biopsy, Pathology Results Often Differ in UTUC

Biopsy, Pathology Results Often Differ in UTUC

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Study results serve as a caution against relying on ureteroscopic biopsy to establish tumor grade and stage, researchers say.

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

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Patients with bladder adenocarcinomas have the best survival, whereas those with small cell carcinomas of the bladder have the worst.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

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In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

Nicotine and nicotine-derived nitrosamine ketone enhance mutational susceptibility in human cells.

Post-Cystectomy UTI Risk Linked to Comorbidities

Post-Cystectomy UTI Risk Linked to Comorbidities

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A Charlson Comorbidity Index score of 2 or higher is an independent risk factor for urinary tract infections within 90 days following radical cystectomy for bladder cancer, study finds.

MRI Differentiates Low-Grade Bladder Tumors

MRI Differentiates Low-Grade Bladder Tumors

Diffusion-weighted imaging and use of higher field strengths further improve accuracy.

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

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The locoregional recurrence-free survival rate at 2 years was significantly higher for patients treated with chemotherapy plus RT versus those treated with chemotherapy alone.

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

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Patients on hemodialysis who undergo radical cystectomy for bladder cancer have 30-day and 5-year mortality rates of 9.3% and 87.9%, respectively, study finds.

Bladder Cancer Risk Higher in Urinary Stone Formers

Bladder Cancer Risk Higher in Urinary Stone Formers

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Patients with versus without a history of urinary calculi had nearly 2-fold greater odds of bladder cancer, meta-analysis showed.

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

40% of active surveillance events were deemed to require treatment.

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

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Chemoradiation for muscle-invasive bladder cancer is associated with a lower 1-year mortality risk versus radical cystectomy, but at year 2 and beyond, mortality risk is lower with radical cystectomy.

Quit Smoking Medications Not Found Effective

Quit Smoking Medications Not Found Effective

No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence.

Few Immuno-Oncology Agents Effective by ASCO Standards

Few Immuno-Oncology Agents Effective by ASCO Standards

Durable survival, response rates rarely recognized as significant by current oncology value frameworks.

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy.

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

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The proportion of patients who received neoadjuvant chemotherapy for muscle-invasive bladder cancer prior to cystectomy rose from 4% to 27% of patients from 1994 to 2013.

Preop Aerobic Exercise May Improve Cystectomy Outcomes

Preop Aerobic Exercise May Improve Cystectomy Outcomes

A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

About 45.1% of cancer deaths and 42% of all incident cancers are linked to modifiable risk factors.

Trimodal Therapy and RC for MIBC Offer Similar Survival

Trimodal Therapy and RC for MIBC Offer Similar Survival

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Mean disease-specific survival at 10 years was 50.9% for TMT and 57.8% for RC patients, a non-significant difference.

Urinary Arsenic Falling in Public Water Consumers

Urinary Arsenic Falling in Public Water Consumers

Reduction occurred after implementation of EPA's maximum contaminant level for arsenic

Fewer Cancer Patients Are Asked to Quit Smoking

Fewer Cancer Patients Are Asked to Quit Smoking

General practitioners less likely to support smoking cessation in patients with cancer than with CHD

Photocure Seeks Expanded Use of Blue Light Cystoscopy

Photocure Seeks Expanded Use of Blue Light Cystoscopy

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FDA has accepted a supplemental New Drug Application asking to expand the labeling indication for Cysview to include use the bladder cancer-detecting system in the outpatient setting.

COBRA Score Gauges Mortality Risk After Cystectomy

COBRA Score Gauges Mortality Risk After Cystectomy

Tool incorporates the relative contribution of tumor stage, lymph node involvement.

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