Bladder Cancer

Trimodal Therapy and RC for MIBC Offer Similar Survival

Trimodal Therapy and RC for MIBC Offer Similar Survival

Mean disease-specific survival at 10 years was 50.9% for TMT and 57.8% for RC patients, a non-significant difference.

Urinary Arsenic Falling in Public Water Consumers

Urinary Arsenic Falling in Public Water Consumers

Reduction occurred after implementation of EPA's maximum contaminant level for arsenic

Fewer Cancer Patients Are Asked to Quit Smoking

Fewer Cancer Patients Are Asked to Quit Smoking

General practitioners less likely to support smoking cessation in patients with cancer than with CHD

Photocure Seeks Expanded Use of Blue Light Cystoscopy

Photocure Seeks Expanded Use of Blue Light Cystoscopy

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FDA has accepted a supplemental New Drug Application asking to expand the labeling indication for Cysview to include use the bladder cancer-detecting system in the outpatient setting.

COBRA Score Gauges Mortality Risk After Cystectomy

COBRA Score Gauges Mortality Risk After Cystectomy

Tool incorporates the relative contribution of tumor stage, lymph node involvement.

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Patients with high alteration number in variants of unknown significance had better outcomes.

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Patients on combination therapy have increased risk of thyroid dysfunction and hypophysitis.

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

The researchers note that TACC3 is a mitotic spindle protein required for accurate segregation of chromosomes, and errors in segregation can lead to aneuploidy, contributing to cancer progression.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

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Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively.

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

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Radical cystectomy is associated with better survival, but findings suggest BPT may produce acceptable oncologic outcomes in appropriately selected patients.

Enhanced Cystoscopy Improves the Care of Bladder Cancer Patients

Enhanced Cystoscopy Improves the Care of Bladder Cancer Patients

The guidelines state that clinicians should offer blue light cystoscopy, if available, as an adjunct to traditional white light cystoscopy (WLC) to increase tumor detection and decrease recurrence.

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

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Instilling mitomycin C within 24 hours of TURBT vs after 2 weeks was associated with a 27% lower risk of recurrence.

Study: Cystectomy Complication Rate Not Improving

Study: Cystectomy Complication Rate Not Improving

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Researchers find no significant change in overall complication rate from 2010 to 2015, but hospital length of stay and need for transfusion have declined.

TERT Test May Improve Detection of Bladder Cancer Recurrence

TERT Test May Improve Detection of Bladder Cancer Recurrence

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In a study, a positive test result was associated with a 5-fold increased risk of recurrent non-muscle invasive bladder cancer.

Robotic, Open Radical Cystectomy Offer Similar Results

Robotic, Open Radical Cystectomy Offer Similar Results

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A new review shows no significant differences in oncologic outcomes, long-term complications, and health-related quality of life between robot-assisted and open radical cystectomy.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

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Symptomatic recurrence was associated with a nearly 2-fold higher risk of death from the time of recurrence versus surveillance-detected recurrence.

Surgery, Combined Modality Offer Similar MIBC Outcomes

Surgery, Combined Modality Offer Similar MIBC Outcomes

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Meta-analysis reveals no significant difference in overall-, disease-specific, and progression-free survival between radical cystectomy and radiation-based, bladder preservation therapy.

MIBC Patients Should Be Followed Long-term After Cystectomy

MIBC Patients Should Be Followed Long-term After Cystectomy

After recurrent disease, 5-year overall survival was worse among patients with late recurrence.

Worse Survival After Robotic Cystectomy Seen at Low-Volume Centers

Worse Survival After Robotic Cystectomy Seen at Low-Volume Centers

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The researchers found lower overall survival among patients undergoing robot-assisted radical cystectomy at hospitals performing 10 or fewer procedures during 2010 to 2012.

Keytruda Approved for All Cancers With Specific Genetic Biomarker

Keytruda Approved for All Cancers With Specific Genetic Biomarker

Of 149 individuals with such tumors who took Keytruda in clinical trials, nearly 40% had a complete or partial remission.

Renal, Bladder Cancer Linked to Physical Inactivity

Renal, Bladder Cancer Linked to Physical Inactivity

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Renal and bladder cancer patients were, respectively, 77% and 73% more likely to report lifetime physical inactivity than controls without cancer.

Pure Bladder Cancer Variants Linked to Worse Survival After RC

Pure Bladder Cancer Variants Linked to Worse Survival After RC

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Patients with a pure variant had significantly lower survival odds than those with pure urothelial carcinoma over a median 6.5 years of follow up.

E-Cigarettes And Increased Risk Of Bladder Cancer Linked

E-Cigarettes And Increased Risk Of Bladder Cancer Linked

Research suggests that both cigarettes and e-cigarettes are tied to an increased risk of bladder cancer.

Real-World mUCB Patient Survival Worse Than in Clinical Trials

Real-World mUCB Patient Survival Worse Than in Clinical Trials

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Just 1 in 4 patients diagnosed with metastatic urothelial carcinoma of the bladder survive for a year, according to US national registry data.

Robot-assisted Radical Cystectomy on the Rise

Robot-assisted Radical Cystectomy on the Rise

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By 2014 to 2015, 1 in 3 bladder cancer surgical procedures performed in the United States were robot-assisted.

Neoadjuvant Chemo Benefits Some Variant MIBC Patients

Neoadjuvant Chemo Benefits Some Variant MIBC Patients

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Researchers find prolonged survival among patients with neuroendocrine muscle-invasive bladder cancer.

Post-chemo PD-L1 Tied to Worse Prognosis in Bladder Cancer Pts

Post-chemo PD-L1 Tied to Worse Prognosis in Bladder Cancer Pts

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Five-year cancer-specific survival rates were 48.1% and 69.6% for PD-L1 positive and negative patients, respectively.

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