The updates come after the Agency made the decision to limit the use of these agents as monotherapy in patients with metastatic urothelial cancer who have not received prior therapy and who have low expression of the protein programmed death ligand 1 (PD-L1).
Bladder preservation for MIBC is associated with a higher mortality rate and greater costs compared with radical cystectomy.
In a randomized study, patients who underwent robotic-assisted and open radical cystectomy had similar 2-year progression survival rates.
Females have worse disease-free, cancer-specific, overall survival versus males with bladder cancer.
In 2015, 69% of surgeries for prostate, bladder, and kidney cancer were performed with robotic assistance, a new meta-analysis shows.
Patients in the highest quintile of urinary albumin excretion had a 4.5-fold increased risk of urothelial cell carcinoma vs those in quintiles 1-3.
Real-world study confirms the improved sensitivity of blue light vs white light cystoscopy (91% vs 79%) for detecting bladder cancer.
Study findings suggest that clinicians should use neoadjuvant chemotherapy in many more muscle-invasive bladder cancer patients.
The 5-year overall survival rate is significantly higher among radical cystectomy patients who receive neoadjuvant vs adjuvant chemotherapy, study finds.
Daily use of aspirin before radical cystectomy is associated with a significant 36% and 30% decreased risk of cancer-specific and all-cause mortality.
A study found that bladder cancer and UTUC occurred in 122.22 and 113.97 per 100,000 persons per year, respectively, among kidney transplant recipients.
Positive results before BCG treatment and at the 6-week instillation are associated with an increased likelihood of disease recurrence and/or progression.
Female sex and need for a blood transfusion are associated with development of Clostridium difficile infection following radical cystectomy.
Large study reveals a significant 15% survival advantage associated with radical cystectomy vs chemoradiation therapy.
Novel immunotherapies and chemotherapies hold promise as non-surgical salvage options.
Enhanced therapeutic effect of bacillus Calmette-Gurin tx in non-muscle invasive bladder cancer.
Men and women who smoke are at 2.3-fold and 2.7-fold increased risk of bladder cancer compared with non-smokers.
Instilling gemcitabine into the bladder immediately following resection of low-grade non-muscle-invasive bladder cancer significantly lowers recurrence risk.
Cystoscopy and cytology remain the standard for diagnosis, but a plethora of urinary biomarkers could someday be a useful adjunct to NMIBC surveillance.
One-year overall survival of 61% for gemcitabine and cisplatin plus ipilimumab.
When combined with cytology, UroSEEK detected 95% of patients who developed bladder cancer
Use of 5-alpha-reductase inhibitors before and after diagnosis of the malignancy is associated with a 15% and 22% decreased risk of bladder cancer mortality, respectively.
In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.
Model, based on 6 factors, predicts overall survival for patients treated with atezolizumab
Appears to be a cost-effective strategy for patients with small size, stage pTa or pT1a recurrent tumors
In a 3-year study, toxic effects of atezolizumab remained manageable and responses durable.
Study results serve as a caution against relying on ureteroscopic biopsy to establish tumor grade and stage, researchers say.
Patients with bladder adenocarcinomas have the best survival, whereas those with small cell carcinomas of the bladder have the worst.
In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.
Nicotine and nicotine-derived nitrosamine ketone enhance mutational susceptibility in human cells.
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