Infection Occurs in One Fourth of Radical Cystectomy Patients

Patients who underwent a radical cystectomy (RC) developed postoperative infection after a median of 13 days.
Patients who underwent a radical cystectomy (RC) developed postoperative infection after a median of 13 days.

Approximately 1 in 4 patients undergoing radical cystectomy (RC) experience an infection within 30 days of surgery, new study findings suggest.

Factors associated with the development of infection include perioperative blood transfusion and prolonged operative time.

Using the American College of Surgeons National Surgical Quality Improvement Project database, a team led by Stephen A. Boorjian, MD, of Mayo Clinic in Rochester, Minnesota, identified 3187 patients who underwent RC and examined factors associated with infection within 30 days of surgery.

Of the 3187 patients, 366 (24%) were diagnosed with postoperative infection at a median of 13 days following surgery, according to a report published online ahead of print in Urologic Oncology. Infections included surgical site infection (SSI), which occurred in 4041 patients (12.7%); sepsis/septic shock (SSI, 405 patients, 12.7%); and urinary tract infection (UTI, 309 patients, 9.7%).

On multivariable analysis, body mass index of 30 kg/m2 or higher, receipt of a perioperative blood transfusion (PBT), and operative time of 480 minutes or more were associated with a statistically significant 1.52, 1.27, and 1.72 times increased odds of infection.

Operative time of 480 minutes or more was independently associated with a significant 1.63, 2.1, and 1.8 times increased odds of SSI, UTI, and sepsis/septic shock, respectively. PBT was associated with a significant 1.33 and 1.29 times increased odds of SSI and sepsis/septic shock, respectively.

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