Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

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The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively.
The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively.

(HealthDay News) — The risk of arterial thromboembolism is increased in the short term among patients with incident cancer, according to a study published in the Journal of the American College of Cardiology.

Babak B. Navi, MD, from Weill Cornell Medicine in New York City, and colleagues identified patients over the age of 66 with a new primary diagnosis of breast, lung, prostate, colorectal, bladder, pancreatic, or gastric cancer, or non-Hodgkin's lymphoma from 2002 through the end of 2011 using the Surveillance Epidemiology and End Results-Medicare linked database. Patients were individually matched to a Medicare enrollee without cancer by demographics and comorbidities, and the 279,719 pairs were followed through the end of 2011.

The researchers found that the 6-month cumulative incidence of arterial thromboembolism was 4.7% and 2.2% in patients with cancer and controls, respectively (hazard ratio, 2.2). The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively (hazard ratio, 2.9). The six-month cumulative incidence of ischemic stroke was 3.0% and 1.6% for patients with cancer and controls, respectively (hazard ratio, 1.9). There was variation in excess risk based on cancer risk; risk correlated with cancer stage, and was usually resolved by one year.

"Patients with incident cancer face a substantially increased short-term risk of arterial thromboembolism," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Reference

  1. Navi BB, Reiner AS, Kamel H, et al. Risk of Arterial Thromboembolism in Patients With Cancer. J Am Coll Cardiol. August 2017. doi: 10.1016/j.jacc.2017.06.047

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