Bladder Cancer Risk Raised in RT-Treated Uterine Cancer Patients

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SAN DIEGO—Uterine cancer patients who have undergone radiotherapy (RT) are at risk of developing bladder cancer and should be evaluated for hematuria, researchers reported at the American Urological Association 2013 annual meeting.

Janet Kukreja, MD, and collaborators at the University of Rochester School of Medicine examined data from the Multiple Primary-Standardized Incidence Ratio (MP-SIR) database as part of the Surveillance, Epidemiology and End Results (SEER) program. Participants included women who were diagnosed with localized or advanced uterine cancer as their first malignant primary from 1980 to 2005.

Bladder cancer developed in 197 of the 40,955 patients who had not undergone RT and 146 of the 15,726 subjects who underwent external beam radiation therapy with or without brachytherapy. The adjusted standardized incidence ratio (SIR) for bladder cancer after any RT was 10; without RT, it was 5.8. The adjusted rate ratio for bladder cancer after any RT was 1.7 times greater than the rate observed in the absence of RT. Fatal bladder cancer after any RT was 2.3 times greater than the rate observed in the absence of RT.

“Given the increased mortality in women with bladder cancer, this may be sufficient cause for routine screening in this specific population,” the authors concluded.

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