Biomarkers Identify Acute Kidney Injury in Emergency Patients

Share this article:

In an international study of 1,635 emergency-department patients, urinary neutrophil gelatinase-associated lipocalin (uNGAL) was the most useful of five urinary biomarkers in predicting the severity and duration of acute kidney injury (AKI) at the time of hospital admission, with 81% specificity and 68% sensitivity at a cutoff of 104 ng/mL.

In the study by Thomas L. Nickolas, MD, MS, and colleagues, which was published in the Journal of the American College of Cardiology (2012;59:246-255), uNGAL and another biomarker, urinary kidney injury molecule 1, predicted a composite outcome of dialysis initiation or death during hospitalization, improved the net risk classification compared with conventional assessments, and identified a substantial subpopulation of patients who had low serum creatinine at hospital admission but were at risk of adverse events.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in News in Brief

More in News in Brief

AVF Placement Less Likely in Metropolitan Areas

Rates of AVF placement in patients approaching HD in the US are significantly lower in metropolitan areas.

ESA Resistance Found To Increase Mortality

Greater resistance to ESA is associated with an increased risk of death among patients on chronic HD.

Overactive Bladder Found to Raise Nocturia Risk

Overactive Bladder Found to Raise Nocturia Risk

In a study, severe nocturia predicted increased mortality risk.