Biomarker Found to Predict AKI in Emergency Patients

Share this article:

A prospective cohort study has shown plasma neutrophil gelatinase-associated lipocalin (NGAL) to be an accurate biomarker for predicting acute kidney injury (AKI) in patients admitted from the emergency department (ED).

As Prasad Devarajan, MD, and colleagues described in the Clinical Journal of the American Society of Nephrology, 21% of 616 persons admitted to a hospital from the ED were classified as AKI.

Compared with other patients, this group had the highest median levels of plasma NGAL (146 to 174 ng/mL at various time points), which increased with AKI severity (207 to 244 ng/mL).

The discriminative ability of plasma NGAL improved with higher grades of severity. The test distinguished AKI from normal function and transient azotemia, and could classify patients into low-, moderate-, and high-risk AKI. Use of plasma NGAL resulted in a net reclassification improvement of 94.3%.

Share this article:
You must be a registered member of RUN to post a comment.

Next Article in News in Brief

More in News in Brief

AVF Placement Less Likely in Metropolitan Areas

Rates of AVF placement in patients approaching HD in the US are significantly lower in metropolitan areas.

ESA Resistance Found To Increase Mortality

Greater resistance to ESA is associated with an increased risk of death among patients on chronic HD.

Overactive Bladder Found to Raise Nocturia Risk

Overactive Bladder Found to Raise Nocturia Risk

In a study, severe nocturia predicted increased mortality risk.