Factors Associated with Depression in BPH Patients

the Renal and Urology News take:

Depression is prevalent among men with benign prostatic hyperplasia (BPH). Now a large Polish study, published in International Urology and Nephrology, has identified factors associated with depressed mood.

Among 4,035 BPH patients surveyed, average age 65, 22% were found to have depressive symptoms as measured by the Beck depression inventory.

Half of BPH patients took a selective alpha 1-selective alpha-adrenolytic (ARA), while the other half received polytherapy of ARA with a 5-alpha reductase inhibitor.

Almost three-quarters of BPH patients were found to have erectile dysfunction (ED), too. Researchers observed that patients with ED were likely to be depressed, and depressed patients were likely to develop ED. Having both depressed mood and ED was linked to lower urinary tract symptoms (LUTS), nocturia, the use of 5-alpha reductase inhibitors, comorbidities, and a sedentary lifestyle, including obesity.

Given the prevalence of depression in BPH, clinicians should ask about their patients' mood and offer appropriate mental health referrals. 

Factors Associated with Depression in BPH Patients
Factors Associated with Depression in BPH Patients
The aim of this observational study was to evaluate the prevalence of depressive symptoms in patients diagnosed with benign prostatic hyperplasia (BPH) and factors affecting their occurrence in a large Polish cohort. However, result suggest that prevalence of depressive symptoms in patients diagnosed with BPH is associated with severity of LUTS, erectile dysfunction, nocturia, BPH pharmacotherapy (5αRIs), sedentary life style, and comorbidities including obesity. 

Methods 

• Four thousand thirty-five men (4,035) diagnosed with BPH participated in the survey (age 65 ± 8 years). 

• The occurrence of symptoms of depression was assessed using the Beck depression inventory, severity of lower urinary tract symptoms (LUTS) on the basis of the international prostate symptoms score, and erectile dysfunction using the international index of erectile function (IIEF-5).

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