Older Paternal Age Reduces IUI Live Birth Rates
Intrauterine insemination success rates decrease by 20% with 10-year increments.
ORLANDO—Advancing paternal age is associated with lower live birth rates, according to findings presented at the American Urological Association 2014 annual meeting.
In a retrospective study of 18,806 stimulated intrauterine insemination (IUI) cycles, Natan Bar-Chama, MD, of Icahn School of Medicine at Mount Sinai in New York, and colleagues found that each 10-year increment in paternal age was associated with a 20% decrease in the live birth rate, after adjusting for standard predictors of live birth.
The mean maternal and paternal ages in the cohort were 36.4 years and 38.4 years, respectively. The cumulative live birth rate was 23%.
“When counseling infertile couples undergoing stimulated IUI, advancing paternal age should be considered an important predictor of live birth success rates,” Dr. Bar-Chama's team concluded in a poster presentation.