Dual Drug Regimen Superior for Easing LUTS

SAN DIEGO—Combination treatment with finasteride and tadalafil improves lower urinary tract symptoms (LUTS) and erectile function better than finasteride alone, data presented at the American Urological Association annual meeting suggest.

Sidney Glina, MD, PhD, of Hospital Ipiranga in Sao Paulo, Brazil, and colleagues, compared the use of finasteride in combination with tadalafil with the use of finasteride and placebo in a study of 696 men aged 45 years and older with LUTS secondary to benign prostatic hyperplasia. Researchers randomized 346 men to the combination arm and 350 to the finasteride/placebo arm.

Baseline mean PSA levels were 2.4 ng/ml and the mean prostate volume was 49.4 mL.

At four, 12, and 26 weeks, the International Prostate Symptom Score improved significantly more in the combination arm than the finasteride/placebo arm. In addition, in sexually active men, the International Index of Erectile Function-Erectile Function domain score improved significantly more in the combination arm at each visit in men with and without erectile dysfunction.

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