Presenting Symptoms May Aid in Initial Bladder Cancer Diagnosis

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ATLANTA—Irritative urinary symptoms are encountered more frequently among patients with bladder cancer who are exposed to bladder carcinogens as a result of occupational activities, according to a Brazilian study presented at the American Urological Association 2012 annual meeting.

Sanarelly Adonias, MD, of the Cancer Institute of São Paulo, and colleagues examined 100 patients with bladder cancer after transurethral resection from 2008 to 2011, 64% of whom were male. Patients were placed in one of two groups: those with no history of occupations linked to bladder cancer risk (Group 1) and those in occupations (such as in the rubber and chemical industries) that exposed them to bladder cancer carcinogens (Group 2).

Patients in Group 2 had a significantly higher incidence of dysuria as a presenting symptom and a non-significantly higher incidence of T1 disease at diagnosis (36% vs. 18%). The two groups showed little or no difference among variables such as rate of recurrence (21% vs. 22%), three or more lesions (22% vs. 19%), or grade. The two groups were similar with respect to other presenting symptoms, such as hematuria and urinary retention.

The researchers concluded that “presenting symptoms may help in the initial bladder cancer diagnosis in patients with a history of occupational exposure.”

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