Surrogate Markers May Identify Age-Associated Biochemical Changes in OAB patients

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WASHINGTON, D.C.—Urinary nerve growth factor (NGF) and MCP-1 may be surrogate markers for monitoring age-associated biochemical changes in patients with overactive bladder (OAB).

In addition, these surrogate markers may better help guide therapeutic interventions in OAB patients, investigators reported at the American Urological Associatino 2011 annual meeting.

Vikas Tyagi, MD, of William Beaumont Hospital in Royal Oak, Mich., and colleagues hypothesized that age-related biochemical changes in the bladder, such as decreased muscle mass, urothelial thinning, and increased collage, result in altered bladder function that can be reflected in altered urinary proteome of elderly OAB patients. The investigators analyzed urine specimens obtained from 74 OAB patients aged 25-90.

The investigators found that the prevalence of OAB increased with age. Univariate analysis of 11 urinary proteins revealed an association between age and four selected proteins in OAB, and urinary NGF had positive modest correlation with age of OAB dry patients. Age-associated biochemical changes in the bladder can be identified in urine proteome, especially in proteins that target specific components of the bladder, such as the urothelium (IP-10) and the afferent sensory nerve pathways (NF and MCP-1). Age-associated elevation of MCP-1 may be related to decreased muscle mass and increased fat in the bladder in older adults with OAB.

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