Overactive Bladder Often Associated with Pelvic Organ Prolapse

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WASHINGTON, D.C.—Posterior compartment pelvic organ prolapse (POP) in women is often associated with overactive bladder (OAB), and POP surgery may help to decrease OAB symptoms as well as detrusor overactive (DO), according to study findings presented at the American Urological Association 2011 annual meeting.

Elisabetta Costantini, MD, of the University of Perugia, Perugia, Italy and colleagues studied 43 patients with posterior vault prolapse who underwent surgery for POP repair. Subjects were followed up at one, three, six, and 12 months postoperatively and then annually. The researchers assessed outcomes with anatomical/physical examinations, patient questionnaires, and urodynamic tests. The mean follow-up was 75 months (range 14- 187 months).

Preoperatively, 33 of the 43 patients (76%) reported OAB and 11 patients (25%) had DO, although two of them had no symptoms. Three patients (6.9%) had persistent posterior compartment prolapse, but no patients required further surgery to correct the recurrence.

Post-operative OAB symptoms disappeared in 25 of the 33 OAB patients (75%), but post-operative storage symptoms persisted in eight patients (24%), according to the investigators.

None of the patients reported new-onset urgency, and DO disappeared in eight of 11 patients (72%) with DO. Constipation was present in 16 of the 33 OAB patients (48%); it resolved in 13 of them (81%).

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