PCA3 May Help Predict Insignificant Prostate Cancer

WASHINGTON, D.C.—Prostate cancer gene 3 (PCA3) may be a valuable predictor of pathologically confirmed low volume disease and insignificant prostate cancer (PCa), according to a study presented at the 2011 annual meeting of the American Urological Association.

Underarm Testosterone Therapy Cleared

WASHINGTON, D.C.—The FDA has approved the first and only testosterone therapy applied to the underarm.

Primary Care Providers Ordering More PSA Tests

WASHINGTON, D.C.—The rate of office-based PSA testing by primary care providers (PCPs) in the United States doubled from 1997 to 2008, according to data presented at the American Urological Association 2011 annual meeting.

Abnormal DREs in Obese Men Predict Greater Risk of Prostate Cancer

WASHINGTON, D.C.—Obese men are less likely to have an abnormal digital rectal examination (DRE) than non-obese men, according to findings presented at the American Urological Association 2011 annual meeting.

Heavier Men Face Higher LUTS Risk

WASHINGTON, D.C.—Elderly men who are overweight or obese are at increased risk for developing lower urinary tract symptoms (LUTS), but those who engage in a relatively high level of physical activity or daily walking for exercise have a reduced risk, data show.

Severe Adverse BPH Outcomes Persist

WASHINGTON, D.C.—Severe adverse outcomes of benign prostatic hyperplasia (BPH) persist despite widespread use of oral therapies, according to a study presented at the American Urological Association 2011 annual meeting.

Trigonal Injections of Botulinum Toxin Improve OAB Outcomes

WASHINGTON, D.C.—Trigonal intradetrusor injections of botulinum toxin-A (BTX-A) results in greater reduction in overactive bladder (OAB) symptoms compared with trigone-sparing BTX-A injections, Irish investigators reported at the American Urological Association 2011 annual meeting.

Statins May Reduce Stone Risk

WASHINGTON, D.C.—Statin use by hyperlipidemic patients may decrease the risk of urinary stone formation, according to study findings presented at the American Urological Association 2011 annual meeting.

Silodosin Found to Ease CP/CPPS Symptoms

WASHINGTON, D.C.—Silodosin may be an effective treatment for moderate or severe chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), researchers reported at the American Urological Association 2011 annual meeting.

Adjuvant Drugs May Aid Clearance of Some Stones

WASHINGTON, D.C.—Adjuvant use of tamsulosin or nifedipine after extracorporeal shock wave lithotripsy (SWL) improves stone free rates in patients treated for non-lower pole renal stones 10-20 mm in diameter, Brazilian researchers reported at the American Urological Association 2011 annual meeting.

Overactive Bladder Often Associated with Pelvic Organ Prolapse

WASHINGTON, D.C.—Posterior compartment pelvic organ prolapse (POP) in women is often associated with overactive bladder (OAB), and POP surgery may help to decrease OAB symptoms as well as detrusor overactive (DO), according to study findings presented at the American Urological Association 2011 annual meeting.

Surrogate Markers May Identify Age-Associated Biochemical Changes in OAB patients

WASHINGTON, D.C.—Urinary nerve growth factor (NGF) and MCP-1 may be surrogate markers for monitoring age-associated biochemical changes in patients with overactive bladder (OAB), according to data presented at the American Urological Association 2011 annual meeting.

Intratumoral CRP May Predict Post-Op RCC Outcomes

WASHINGTON, D.C.—Intratumoral C-reactive protein (CRP) may be a robust biomarker of prognosis in patients with local renal cell carcinoma (RCC), investigators reported at the American Urological Association 2011 annual meeting.

Overweight Young Men Face High Risk of Enlarged Prostates

Overweight Young Men Face High Risk of Enlarged Prostates

WASHINGTON, D.C.—Overweight young men are more likely than normal-weight men to develop an enlarged prostate later in life, researchers reported.

Modest Weight Loss Does Not Prevent LUTS

Modest Weight Loss Does Not Prevent LUTS

WASHINGTON, D.C.—Although obesity has been linked with lower urinary tract symptoms (LUTS) in aging men, modest weight loss may not prevent onset or progression of LUTS in this population, new findings presented at the American Urological Association 2011 annual meeting suggest.

Statins May Improve Urologic Symptoms in Men

WASHINGTON, D.C.—Statin use may decrease the occurrence of lower urinary tract symptoms (LUTS) among men, but not women, researchers reported at the American Urological Association 2011 annual meeting.

African-American Men Less Likely to Receive BPH Treatment

WASHINGTON, D.C.—African American men are less likely to receive treatment for benign prostatic hyperplasia (BPH) compared with other races, according to findings presented at the American Urological Association 2011 annual meeting.

'OAB-Dry' May Need to be Reassessed

WASHINGTON, D.C.—Questionnaires used to diagnose patients with overactive bladder (OAB) may identify anyone with polyuria, bladder hypersensitivity, and even OAB-wet with rare leakage episodes as OAB-dry, investigators reported at the American Urological Association 2011 annual meeting.

Pre-Cystectomy Smoking Linked to Worse Outcomes After Surgery

Pre-Cystectomy Smoking Linked to Worse Outcomes After Surgery

WASHINGTON, D.C.—Pre-cystectomy smoking habits influence survival following radical cystectomy for bladder cancer, according to researchers.

Overactive Bladder Found in One Fifth of Type 2 Diabetics

WASHINGTON, D.C—Japanese researchers found that more than one fifth of patients with type 2 diabetes receiving care at a dedicated diabetes center have overactive bladder (OAB).

Nocturia Is the Most Bothersome OAB Symptom in POTS Patients

WASHINGTON, D.C.—Nocturia is the most common overactive bladder (OAB) symptom affecting health-related quality of life (HRQL) in patients with postural tachycardia syndrome (POTS), investigators reported at the American Urological Association 2011 annual meeting.

Parkinson's Severity Associated with OAB Symptoms

WASHINGTON, D.C.—Overactive bladder (OAB) symptoms are common in patients with Parkinson's disease regardless of age and gender, and the severity of Parkinson's symptoms correlates with OAB symptoms, according to a study presented at the American Urological Association 2011 annual meeting.

Extracapsular Extension Predicts Late PCa Recurrence

Extracapsular Extension Predicts Late PCa Recurrence

WASHINGTON, D.C.—Prostate cancer (PCa) patients found to have extracapsular extension after radical prostatectomy have a greater risk of biochemical recurrence (BCR) recurrence 10 years after surgery, researchers reported at the American Urological Associatoin 2011 annual meeting.

Active Surveillance Offers PCa Survival Similar to Treatment

WASHINGTON, D.C.—Active surveillance for screen-detected localized prostate cancer (PCa) does not increase the risk of death from prostate cancer (PCa) relative to definitive local treatment, according to study findings presented at the American Urological Association 2011 annual meeting.

RARP Offers Favorable Long-Term Outcomes

WASHINGTON, D.C.—Robot-assisted radical prostatectomy (RARP) for localized prostate cancer (PCa) offers favorable intermediate- and long-term oncologic outcomes, researchers reported at the American Urological Association 2011 annual meeting.

OAB Symptoms Linked to Elevated Serum Leptin

WASHINGTON, D.C.—Elevation of serum leptin and a decrease in monocyte chemotactic protein-1 (MCP-1) levels are associated with overactive bladder (OAB) symptoms, according to new data presented at the American Urological Association 2011 annual meeting.

Large Renal Masses Grow Faster than Small Ones

WASHINGTON, D.C.—Renal masses greater than 4 cm in diameter tend to grow faster than smaller masses, a researcher reported at the American Urological Association 2011 annual meeting.

ADT May Increase Proteinuria Risk in African-American Men

WASHINGTON, D.C.—African-American race and older age are risk factors for development of proteinuria in men who receive androgen deprivation therapy (ADT) for prostate cancer (PCa), according to data presented at the American Urological Association 2011 annual meeting.

Sacral Neuromodulation Found Effective and Well-Tolerated

WASHINGTON, D.C.—Sacral neuromodulation with InterStim Therapy is safe and well tolerated as a treatment for patients with overactive bladder and those with urinary retention, French investigators reported at the American Urological Association 2011 annual meeting.

Adverse Events Common After Botulinum Toxin Injections

WASHINGTON, D.C.—Adverse events (AEs) after intravesical botulinum toxin type A for idiopathic detrusor overactivity (IDO) are encountered frequently, according to a new study presented at the American Urological Association 2011 annual meeting.

Botulinum Toxin Effective Long Term for Severe OAB

WASHINGTON, D.C.—Detrusor botulinum toxin type A injections are a safe and effective treatment long-term for patients with severe overactive bladder (OAB), Swiss researchers reported at the American Urological Association 2011 annual meeting.

Erectile Dysfunction Linked to High Uric Acid

WASHINGTON, D.C.—Elevated serum uric acid levels may be a marker for an increased risk of erectile dysfunction (ED), Iranian researchers reported at the American Urological Association 2011 annual meeting.

Extensive PLND May Improve Prostate Cancer Outcomes

WASHINGTON, D.C.—The extent of pelvic lymph node dissection (PLND) significantly affects the likelihood of biochemical recurrence (BCR) in patients with organ-confined prostate cancer (PCa), researchers reported at the American Urological Association 2011 annual meeting.

Cyclosporine Tested As Treatment for Difficult Interstitial Cystis Cases

WASHINGTON, D.C.—A urologist told attendees of the American Urological Association 2011 annual meeting he has had promising results using cyclosporine A off-label to treat patients with severely symptomatic refractory interstitial cystitis (IC).

Cardiovascular Mortality Not Increased with ADT

WASHINGTON, D.C.—Contrary to emerging evidence, a new study suggests that androgen deprivation therapy (ADT) does not increase the risk of cardiovascular mortality, according to data presented at the American Urological Association 2011 annual meeting.

Aggressive Prostate Tumors Linked to Diabetes

WASHINGTON, D.C.—Although studies have suggested that men with diabetes mellitus (DM) are at lower risk of prostate cancer (PCa), new findings suggest that DM is associated with a significantly increased risk of aggressive prostate tumors, researchers reported at the American Urological Association 2011 annual meeting.

OAB Affects Work Productivity

WASHINGTON, D.C.—Men and women who suffer from overactive bladder (OAB) report significantly greater levels of work limitations compared with those without urinary symptoms, according to a new study presented at the American Urological Association 2011 annual meeting.

Partial Nephrectomy Use Increasing, but Still Underused

WASHINGTON, D.C.—The rate of partial nephrectomy (PN) performed on patients with renal cell carcinoma (RCC) has increased nearly fourfold from 1998 to 2007 in the United States, but it is still underused, researchers reported at the American Urological Association 2011 annual meeting.

RCC Surgery Outcomes Worse in Nutritionally Deficient Patients

RCC Surgery Outcomes Worse in Nutritionally Deficient Patients

WASHINGTON, D.C.—Nutritional deficiency (ND) is independently associated with higher mortality after surgery for renal cell carcinoma (RCC), according to findings presented at the American Urological Association 2011 annual meeting.

Lymph Node Density May Help Predict Bladder Cancer Death Risk

WASHINGTON, D.C.—Lymph node density (LN-density) may have prognostic relevance in patients with lymph node-positive bladder cancer (LNposBCA), according to a new German study presented at the American Urological Association 2011 annual meeting.

Robot-Assisted Radical Cystectomy Safe, Feasible for Octogenarians

WASHINGTON, D.C.—Robot-assisted radical cystectomy (RARC) is safe and feasible in octogenarians, researchers reported here at the American Urological Association 2011 annual meeting.

Prostate Cancer Risk Linked to Family History of Breast, Upper GI Cancer

WASHINGTON, D.C.—It is known that men who have a family history of prostate cancer (PCa) are at increased risk of the malignancy, but a new study shows that a family history of other cancers in first-degree relatives may increase that risk as well, according to findings presented at the American Urological Association 2011 annual meeting.

Remission of Urologic Symptoms Not Uncommon

WASHINGTON, D.C.—The natural history of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) may involve as much remission as progression, according to a new longitudinal study presented at the American Urological Association 2011 annual meeting.

Obesity Raises Risk of Aggressive Prostate Cancer

WASHINGTON, D.C.—Obesity is associated with a decreased risk of low-grade and increased risk of high-grade prostate cancer (PCa), according to study data presented at the American Urological Association 2011 annual meeting.

Adjuvant RT Better for Locally Advanced PCa

WASHINGTON, D.C.—Adjuvant radiotherapy (RT) may be associated with better disease-specific survival than salvage RT among men who have undergone radical prostatectomy (RP) for locally advanced prostate cancer (PCa), researchers reported at the American Urological Association 2011 annual meeting.

Eating Barbecued Hamburgers Well Done May Raise Risk of Advanced Prostate Cancer

Eating Barbecued Hamburgers Well Done May Raise Risk of Advanced Prostate Cancer

WASHINGTON, D.C.—Men who eat grilled or barbecued hamburgers or any red meat that is well done or very well done may be at increased risk for advanced prostate cancer (PCa), according to data presented at the American Urological Association 2011 annual meeting.

IMRT Largely Replaces EBRT for Prostate Cancer

WASHINGTON, D.C.—Intensity-modulated radiotherapy (IMRT) has largely replaced 3D external beam radiotherapy (EBRT) as the preferred radiation treatment for localized prostate cancer (PCa), according to data presented at the American Urological Association 2011 annual meeting.

Smoking Cessation Counseling by Urologists May Work Short Term

WASHINGTON, D.C.—Limited smoking cessation counseling by urologists may affect short-term abstinence rates in the perioperative period, according to preliminary results of a pilot study presented at the American Urological Association 2011 annual meeting.

Bladder and Ureteral Injury after GI Surgery on the Rise

WASHINGTON, D.C.—Lower urinary tract (LUT) injury following gastrointestinal (GI) surgery is on the increase, according to data presented at the American Urological Association 2011 annual meeting.

Stone Incidence Rising Among Adolescents

WASHINGTON, D.C.—The incidence of renal stones has doubled among adolescents over a 25-year period, but has remained stable in younger individuals, investigators reported at the American Urological Association 2011 annual meeting.

Mortality from Renal and Pelvis Cancers Higher in Places with Fewer Docs

WASHINGTON, D.C.—Mortality rates from kidney and renal pelvis cancers (KCa) are increased significantly in places with a low population density of physicians, according to a study presented at the American Urological Association 2011 annual meeting.

Osteoporosis Program Helps Men on Androgen Suppression for Prostate Cancer

WASHINGTON, D.C.—Men receiving androgen suppression for prostate cancer (PCa) and participated in an osteoporosis disease management program had a significantly decreased incidence of hip fractures compared with those not in the program, according to a study presented at the American Urological Association 2011 annual meeting.

Overactive Bladder Highly Prevalent, Study Finds

WASHINGTON, D.C.—Overactive bladder (OAB) is highly prevalent in both women and men and the prevalence varies by race and ethnicity, according to study findings presented at the American Urological Association 2011 annual meeting.

Poor Sleep May Raise Risk of Urologic Symptoms

WASHINGTON, D.C.—Poor sleep quality may be a novel and modifiable risk factor that precedes the development of urologic symptoms in men and women, according to finding presented at the American Urological Association 2011 annual meeting.

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