PSA Rises More Slowly with Age in Diabetics

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SAN FRANCISCO—Men with diabetes experience significantly smaller increases in PSA level as they age compared with non-diabetics, according to findings reported here at the American Urological Association Annual Meeting.

Researchers analyzed data obtained from 569 Caucasian men aged 40-79 (mean age 53.1 years) who had enrolled in a study in 1990 and had at least two PSA measurements. Subjects had a median follow-up of 8.4 years (maximum 15 years).

The overall mean change in PSA level was 3.6% per year and increased significantly with age, according to a team led by Lauren Wallner, PhD, MPH, a research fellow at the University of Michigan in Ann Arbor. After adjusting for age, the mean change in PSA level was 1.1 % among men with diabetes compared with 3.7% for non-diabetics. The change in PSA did not differ significantly by hypertension status after adjusting for age.

“As lower levels of serum PSA as men age potentially influences the detection of prostate cancer, it is plausible that the presence of diabetes may lead to fewer prostate cancers being detected among men with diabetes,” Dr. Wallner told Renal & Urology News. “As such, as screening guidelines are revised for prostate cancer, it may be prudent to take into consideration the presence of metabolic conditions.”

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