Living Kidney Donor Graft Survival Improving

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Ten-year graft survival increased from 56.1% in 1987–1994 to 58.6% and 62.6% in 1995–2001 and 2002–2008, respectively.
Ten-year graft survival increased from 56.1% in 1987–1994 to 58.6% and 62.6% in 1995–2001 and 2002–2008, respectively.
The following article is part of conference coverage from the 2017 American Transplant Congress (ATC) in Chicago, Illinois. Renal and Urology News' staff will be reporting breaking news associated with research conducted by leading experts in transplantation. Check back for the latest news from ATC 2017.

Graft survival has improved significantly among recipients of kidneys from living donors despite increased recipient and donor age and less biological relatedness, researchers reported at the 2017 American Transplant Congress in Chicago.

Using the United Network for Organ Sharing database, Vaughn E. Whittaker, MD, and colleagues at the State University of New York at Syracuse studied 114,620 adults who received kidneys from living donors from 1987 to 2015. The investigators divided the study period into 4 eras: 1987–1994, 1995–2001, 2002–2008, and 2009–2015. 

For patients who received kidney transplants in these eras, the 5-year graft survival rates increased with each successive era: 76.6%, 79.7%, 83.1%, and 85.4%, respectively. Ten-year graft survival increased from 56.1% in 1987–1994 to 58.6% and 62.6% in 1995–2001 and 2002–2008, respectively. The 15-year graft survival rate rose from 37.7% in 1987–1994 to 39.9% in 1995–2001.

During 1987–1994, 1995–2001, 2002–2008, and 2009–2015, the median age of recipients was 36, 43, 48, and 50 years, respectively, and the median age of donors was 37, 39, 41, and 43 years, respectively. Biological relatedness decreased from 93.6% in 1987–1994 to 76.9%, 62.5%, and 50.1% in 1995–2001, 2002–2008, and 2009–2015, respectively.

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Reference

Whittaker V, Gruessner R, Laftavi M, et al. Outcome of adult living donor renal transplants in different era: Analysis of UNOS database. [abstract]. Am J Transplant 2017;17 (suppl 3). Poster presented at the 2017 American Transplant Congress in Chicago, April 29–May 3. Abstract A235.


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