Low Vitamin D, Anemia Linked in CKD Patients

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PHOENIX—Chronic kidney disease (CKD) patients with anemia have significantly lower levels of 25 vitamin D (25D) than those without anemia, researchers concluded.

Secundino Cigarrán, MD, of Hospital Da Costa, Lugo, Spain, and colleagues enrolled 563 CKD patients with a mean age of 68 years and a mean estimated glomerular filtration rate (eGFR) of 46.67 mL/min/1.73 m2. The study population was 38% female and 30% diabetic. Subjects' mean hemoglobin level was 13.16 g/dL. Of the 563 patients, 201 (35.9%) had anemia-defined Hb levels (less than 12.5 g/dL).

Mean 25D levels in the anemic and nonanemic patients were 16.7 and 18.6 ng/mL, respectively, Dr. Cigarrán reported at the 31st Annual Dialysis Conference. Mean levels of 1,25 hydroxyvitamin D did not differ between the groups (34.6 and 40.85 pg/mL).

In addition, anemic patients were significantly older than nonanemic patients (71 vs. 66 years) and were more likely to be diabetic (35.6% vs. 25.7%) and to have a lower eGFR (36.54 vs. 52.36). Anemic patients had significantly lower serum albumin levels (4.18 vs. 4.34 g/dL), lower calcium levels (9.20 vs. 9.38 mg/dL), and higher phosphorus (3.76 vs. 3.41 mg/dL).

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