Good Residual Renal Function Improves HD Patient Outcomes

Researchers observe significantly higher levels of albumin and hemoglobin and better calcium and phosphate metabolism.
Researchers observe significantly higher levels of albumin and hemoglobin and better calcium and phosphate metabolism.

SEATTLE—Residual renal function (RRF) may help to improve nutritional status, anemia, and calcium-phosphate metabolism in patients on maintenance hemodialysis (HD), according to findings presented at the 2016 Annual Dialysis Conference.

The findings are from a study of 120 maintenance HD patients by Wenly Lyu, MD, and colleagues from Fudan University in Shanghai, China. The investigators classified patients as RRF+ if their RRF was 1 mL/min/1.73 m2 or higher (48 patients) or RRF− if RRF was less than 1 mL/min/1.73 m2 (72 patients).

The 120 patients had a 24-hour residual urine volume of 489.54 mL and an average urea nitrogen clearance rate of 1.52 mL/min. The blood albumin level and hemoglobin levels were significantly higher in the RRF+ than the RRF− patients (36.21 vs. 34.25 g/L and 109 vs. 105 g/L, respectively), the researchers reported.  In addition, the RRF+ group had significantly higher proportions of patients with serum calcium levels between 2.0 and 2.5 mmol/L (33.3% vs. 27.7%), serum phosphorus levels less than 1.5 mmol/L (37.5% vs. 33.3%), and parathyroid hormone levels below 300 pg/mL (41.6% vs. 38.8%).

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