Company asks FDA to approve ferric citrate for iron deficiency anemia in patients with non-dialysis dependent chronic kidney disease.
Decreased use of erythropoiesis-stimulating agents and an uptick in peritoneal dialysis use are among the trends.
Older men on TRT versus placebo for 1 year had improved hemoglobin levels and volumetric bone mineral density and estimated bone strength.
CKD patients with larger erythrocyte volumes had more than triple the risk of dying from cardiovascular causes, researchers reported.
Investigators observed no difference in hemoglobin level between transplant recipients and non-transplant CKD patients starting hemodialysis.
New and established peritoneal dialysis patients both showed this trend.
In a study 52.1% of patients receiving ferric citrate attained a 1.0 g/dL or greater increase in hemoglobin compared with just 19.1% receiving placebo.
New study finds no difference in all-cause and cause-specific mortality between iron sucrose and sodium ferric gluconate complex.
Use of ESAs declined while use of blood transfusions increased between 2008 and 2012.
The surface chemistry of the polymer reacts to the pH level of blood as it travels through the body.
The condition is present in more than half of Medicare patients with stage 3-5 chronic kidney disease.
US patients receive higher intravenous iron and ESA doses during the first year of hemodialysis compared with those in Europe.
Low vitamin D status was associated with a 2-fold higher risk for anemia.
Results were homogeneous, with differences in absolute mortality consistently less than 1% among the most extreme exposure categories.
Pending future research, patients should avoid taking more than 120 mg per day.
SHPT patients who received 6 months of cinacalcet treatment had a 10% increase in the odds of reaching target hemoglobin levels.
Study finds no increased risk of major adverse cardiovascular events and death.
Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.
Management strategy also is associated with reduced mortality risk, but not achievement of hemoglobin targets.
End-stage renal disease is 32% more likely to develop in patients with C-reactive protein levels of 6.9 mg/L or higher vs 3.0 mg/L or lower.
Other risk factors include reduced muscle mass and lower levels of physical activity.
A recent study resulted in a new definition of less-than-optimal response to erythropoiesis-stimulating agents.
A hemoglobin level of 10.5 g/dL offers the optimal balance of cost and quality adjusted life years, researchers conclude.
The odds of developing anemia were 2-fold greater among patients with than without diabetes mellitus.
Anemia was associated with impaired activity levels at CKD stages 3, 4, and dialysis.
IV administration of vitamin B6 did not improve anemia or abnormal bone metabolism over 6 months.
Average weekly doses greater than 70 µg/week was associated with a 77% increased risk of cancer compared with no ESA exposure.
A high erythropoietin resistance index was associated with triple the risk for death from any cause.
Patients provided small doses of intravenous iron per treatment achieved higher hemoglobin levels than patients receiving weekly iron.
In a small study, 82% of patients had iron overload prior to hemodialysis initiation.
Renal and Urology News Articles
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)