Ferumoxytol and iron sucrose have comparable safety in the treatment of anemia in patients with CKD.
Platelets may aggregate more easily in iron-deficient patients.
Soluble ferric pyrophosphate (Triferic), an investigational drug, is delivered to hemodialysis patients via dialysate.
Geriatric patients with CKD are at high risk for morbidity and mortality from the potential side effects of treatments.
In a study, ferumoxytol and iron sucrose treatment was associated with comparable increases in hemoglobin levels and adverse event rates.
This trait in African-American hemodialysis patients was associated with a 13.2% higher dose of erythropoiesis-stimulating agents.
Decreasing TSAT and higher ESA doses are associated with increasing platelet counts.
Folic acid treatment significantly improved hemoglobin levels and decreased epoetin alfa use.
Elemental iron requirement was reduced by half in patients receiving ferric citrate versus an active control.
These include use of lower ESA doses and hemoglobin levels.
Weekly dose of erythropoiesis-stimulating agents decreased and hemoglobin levels increased.
Patients with levels below 10 g/dL had the highest unadjusted mortality and all-cause hospitalization rates.
A transferrin saturation of 20% or less was associated with a 2.2 times increased risk of death from any cause.
Study also documents use of higher IV iron doses and declining hemoglobin levels.
Plasma ascorbic acid levels in the physiologic range correlated inversely with EPO resistance.
Soluble ferric pyrophosphate is a unique carbohydrate-free formulation administrated via dialysate.
Children on dialysis who have anemia and require high doses of drugs to treat it are at increased risk of dying prematurely.
Soluble ferric pyrophosphate significantly decreased ESA use while maintaining target hemoglobin levels without increasing iron stores.
The trend is most pronounced among Medicare recipients since the debut of bundling, ESA labeling changes.
Study also showed an increase in the proportion of patients with hemoglobin level below 10 g/dL and in transfusion rates.
Voluntary recall of anemia drug due to reports of anaphylaxis, including three deaths
Preoperative anemia associated with elevated risk of deaths from other illnesses.
Once-monthly injections of peginesatide are as effective as one to three injections per week of epoetin in maintaining hemoglobin levels.
No major adverse events reported with administering 1.02 grams of ferumoxytol in patients with iron deficiency anemia.
Meta-analysis also reveals an increased risk of vascular access thrombosis, but no increased likelihood of end-stage renal disease.
Hematocrit decreases as estimated glomerular filtration rate (eGFR) declines in hypertensive chronic kidney disease (CKD) patients.
Patients initiating daily hemodialysis (DHD) face a significant decrease in mean hemoglobin (Hb), hematocrit, and transferrin.
Intravenous ascorbic acid (IVAA) can be a potent and effective adjuvant treatment for hemodialysis patients who have normoferritinemic anemia resistant to treatment with erythropoietin (EPO).
Epoetin use and hemoglobin (Hb) levels have declined similarly for black and non-black dialysis patients following the advent of Medicare's system of "bundled" payments.
Iron deficiency in the absence of anemia is associated with intradialytic hypotension (IDH), a finding that suggests iron has a role beyond erythropoiesis.