Anemia

Hypogonadism in Male HD Patients Linked to Poor ESA Response

Hypogonadism in Male HD Patients Linked to Poor ESA Response

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Other risk factors include reduced muscle mass and lower levels of physical activity.

Hemodialysis Patient Hyporesponsiveness to ESAs Ups Death Risk

Hemodialysis Patient Hyporesponsiveness to ESAs Ups Death Risk

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A recent study resulted in a new definition of less-than-optimal response to erythropoiesis-stimulating agents.

Most Cost-Effective Hb Target in Anemic CKD Patients Identified

Most Cost-Effective Hb Target in Anemic CKD Patients Identified

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A hemoglobin level of 10.5 g/dL offers the optimal balance of cost and quality adjusted life years, researchers conclude.

Diabetes May Increase Anemia Risk in CKD Patients

Diabetes May Increase Anemia Risk in CKD Patients

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The odds of developing anemia were 2-fold greater among patients with than without diabetes mellitus.

Anemic CKD Patients Have Lower Health-Related Quality of Life

Anemic CKD Patients Have Lower Health-Related Quality of Life

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Anemia was associated with impaired activity levels at CKD stages 3, 4, and dialysis.

ESA Resistance Linked to Vitamin B6 Treatment

ESA Resistance Linked to Vitamin B6 Treatment

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IV administration of vitamin B6 did not improve anemia or abnormal bone metabolism over 6 months.

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

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Average weekly doses greater than 70 µg/week was associated with a 77% increased risk of cancer compared with no ESA exposure.

ESA-Resistance Linked to Early Death

ESA-Resistance Linked to Early Death

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A high erythropoietin resistance index was associated with triple the risk for death from any cause.

Is Giving Small Iron Doses Per Dialysis Session Better for Patients?

Is Giving Small Iron Doses Per Dialysis Session Better for Patients?

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Patients provided small doses of intravenous iron per treatment achieved higher hemoglobin levels than patients receiving weekly iron.

Hepatic Iron Overload May Be Common Before Dialysis

Hepatic Iron Overload May Be Common Before Dialysis

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In a small study, 82% of patients had iron overload prior to hemodialysis initiation.

Anemia Prevalence, Treatment in Non-Dialysis CKD Varies by Country

Anemia Prevalence, Treatment in Non-Dialysis CKD Varies by Country

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Less than half of anemic patients were prescribed ESAs or iron in the US and France, and a high percentage overall did not have iron indices measured.

ESA Doses Lower Among Dialysis Patients at Higher Elevations

ESA Doses Lower Among Dialysis Patients at Higher Elevations

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Investigators find that the normalized mean ESA dose decreases as patients' elevation of residence increases.

Higher Conversion Ratio for Epoetin Beta to Darbepoetin Alfa

Higher Conversion Ratio for Epoetin Beta to Darbepoetin Alfa

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Researchers confirmed higher dose conversion ratios in Taiwanese patients with stable hemoglobin.

Anemia Risk Factors in Peritoneal Dialysis Patients ID'd

Anemia Risk Factors in Peritoneal Dialysis Patients ID'd

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New findings implicate transferrin saturation and nutritional status assessed by albumin.

TRT Found to Reduce Anemia in Hypogonadal Men

TRT Found to Reduce Anemia in Hypogonadal Men

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After 54 weeks of treatment with testosterone undecanoate, anemia prevalence decreased from 29.6% to 10%.

Managing Anemia in Cancer Patients With CKD

Managing Anemia in Cancer Patients With CKD

A summary of Dr. Jeffrey S. Berns' presentation that will be given at the National Kidney Foundation's 2016 Spring Clinical Meetings in Boston, MA.

Ferritin Levels Rising in Hemodialysis Patients

Ferritin Levels Rising in Hemodialysis Patients

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Trend is independent of intravenous iron use and exposure to erythropoiesis-stimulating agents.

CERA Safe, Effective in Patient Subgroups

CERA Safe, Effective in Patient Subgroups

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No new adverse events observed in patients with underlying cardiovascular risk factors who switched to continuous erythropoietin receptor activator.

Platelet/Lymphocyte Ratio May Predict ESA Resistance

Platelet/Lymphocyte Ratio May Predict ESA Resistance

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Greater hyporesponsiveness to erythropoiesis-stimulating agents was associated with increased PLR ratios.

Dialysis Bundling, ESA Labeling Changes Did Not Increase Mortality

Dialysis Bundling, ESA Labeling Changes Did Not Increase Mortality

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Observed rates of all-cause and cardiovascular mortality and myocardial infarction were consistent with expected rates, study shows.

Good Residual Renal Function Improves HD Patient Outcomes

Good Residual Renal Function Improves HD Patient Outcomes

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Researchers observe significantly higher levels of albumin and hemoglobin and better calcium and phosphate metabolism.

ESAs Don't Improve Anemia Patients' Quality of Life

ESAs Don't Improve Anemia Patients' Quality of Life

Based on effect of erythropoietin-stimulating agents for higher hemoglobin targets.

ESRD Anemia Responds to Investigational Oral Drug

ESRD Anemia Responds to Investigational Oral Drug

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In a phase 2 trial, roxadustat maintained hemoglobin levels over 19 weeks as well as epoetin alfa.

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

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In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.

Earlier ESA Initiation May Improve Renal Outcomes

Earlier ESA Initiation May Improve Renal Outcomes

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Study shows benefit of initiating epoetin beta therapy at hemoglobin levels not less than 10 g/dL in non-dialysis CKD patients.

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

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Treatment corrects anemia and improves quality of life, according to a systemic review.

Ergocalciferol Supplements Improve Vitamin D Deficiency, Not Anemia

Ergocalciferol Supplements Improve Vitamin D Deficiency, Not Anemia

Six-months of supplementation has no impact on epoetin utilization in HD patients with low 25(OH)D.

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

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In a study, investigators observed that levels were higher in those with stage 3a than stage 3b chronic kidney disease.

Weekly ESA Dosing at Dialysis Centers May Offer Time Savings

Weekly ESA Dosing at Dialysis Centers May Offer Time Savings

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The estimated potential staff time savings totaled 23 hours for an average facility with 70 patients, researchers found.

Ferumoxytol Similar in Safety to Other IV Iron Products

Ferumoxytol Similar in Safety to Other IV Iron Products

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Rates of death and important non-fatal outcomes between ferumoxytol and iron sucrose or sodium ferric gluconate do not differ significantly.

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