Geriatric patients with CKD are at high risk for morbidity and mortality from the potential side effects of treatments.
Children on dialysis who have anemia and require high doses of drugs to treat it are at increased risk of dying prematurely.
Completely correcting anemia in kidney transplant recipients may preserve kidney function better than partially correcting anemia.
Ferumoxytol and iron sucrose have comparable safety in the treatment of anemia in patients with CKD.
Platelets may aggregate more easily in iron-deficient patients.
Soluble ferric pyrophosphate (Triferic), an investigational drug, is delivered to hemodialysis patients via dialysate.
In a study, ferumoxytol and iron sucrose treatment was associated with comparable increases in hemoglobin levels and adverse event rates.
This trait in African-American hemodialysis patients was associated with a 13.2% higher dose of erythropoiesis-stimulating agents.
Decreasing TSAT and higher ESA doses are associated with increasing platelet counts.
Folic acid treatment significantly improved hemoglobin levels and decreased epoetin alfa use.
Elemental iron requirement was reduced by half in patients receiving ferric citrate versus an active control.
These include use of lower ESA doses and hemoglobin levels.
Weekly dose of erythropoiesis-stimulating agents decreased and hemoglobin levels increased.
Patients with levels below 10 g/dL had the highest unadjusted mortality and all-cause hospitalization rates.
A transferrin saturation of 20% or less was associated with a 2.2 times increased risk of death from any cause.
Study also documents use of higher IV iron doses and declining hemoglobin levels.
Plasma ascorbic acid levels in the physiologic range correlated inversely with EPO resistance.
Soluble ferric pyrophosphate is a unique carbohydrate-free formulation administrated via dialysate.