Androgen Deprivation

Statins Plus ADT After Prostate Cancer Radiotherapy Ups Survival

Statins Plus ADT After Prostate Cancer Radiotherapy Ups Survival

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Researchers observed a significant 36% decreased overall and prostate cancer-specific mortality.

Radiation Plus ADT Beneficial in Node-Positive Prostate Cancer

Radiation Plus ADT Beneficial in Node-Positive Prostate Cancer

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The 5-year risk of overall mortality is decreased by 50% compared with androgen deprivation therapy alone.

Adding Statins to ADT May Delay PCa Progression

Adding Statins to ADT May Delay PCa Progression

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Prostate cancer progression was delayed by a median 10 months in statin users.

Bipolar Androgen Therapy Helps Hormone Therapy-resistant PCa

Bipolar Androgen Therapy Helps Hormone Therapy-resistant PCa

Small study suggests alternating testosterone levels may make hormonal therapy work longer for prostate cancer patients.

ADT-RT Combo Offers Better Outcomes

ADT-RT Combo Offers Better Outcomes

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Longer cancer-specific and overall survival seen in older men with locally advanced or high-risk PCa

PSA Doubling Time Predicts Salvage Radiation Outcomes

PSA Doubling Time Predicts Salvage Radiation Outcomes

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PSA doubling time of 6 months or less and seminal vesicle invasion were significant predictors of biochemical recurrence.

Prolonged Prostate Cancer Hormone Therapy Raises Fracture Risk

Prolonged Prostate Cancer Hormone Therapy Raises Fracture Risk

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Androgen-deprivation therapy (ADT) for more than 1 year is associated with a 2.5 times higher odds of fracture in prostate cancer patients.

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone replacement therapy (TRT) may lower hemoglobin levels and improve lipid profile in diabetic men with androgen deficiency.

Androgen Deprivation Therapy (ADT) Raises Heart-Related Death Risk

Androgen Deprivation Therapy (ADT) Raises Heart-Related Death Risk

But overall risk of heart-related death risk from prostate cancer treatment is small, researchers say.

Chemo-ADT Combo Ups Survival in Patients with Metastatic PCa

Chemo-ADT Combo Ups Survival in Patients with Metastatic PCa

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Starting docetaxel with androgen deprivation therapy prolonged median overall survival by more than 13 months versus ADT alone.

ADT May Be Safely Deferred After PSA Relapse

ADT May Be Safely Deferred After PSA Relapse

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Immediate ADT found to offer little or no survival advantage to prostate cancer who experience biochemical recurrence.

Adding ADT to Radiotherapy Improves Prostate Cancer Outcomes

Adding ADT to Radiotherapy Improves Prostate Cancer Outcomes

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The combined treatment was associated with a reduced risk of biochemical and clinical progression compared with radiotherapy alone.

Osteoporosis May Be Present Before Prostate Cancer ADT

Osteoporosis May Be Present Before Prostate Cancer ADT

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Danish study reveals a 10% prevalence of osteoporosis among men due to start androgen-deprivation therapy.

PSA Nadir in ADT Recipients: The Lower, The Better

PSA Nadir in ADT Recipients: The Lower, The Better

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The nadir should be below 0.01 ng/mL because even levels of 0.01 to 0.2 ng/mL predict an increased risk of adverse outcomes.

Primary ADT Not Beneficial in Most Cases of Early Prostate Cancer

Primary ADT Not Beneficial in Most Cases of Early Prostate Cancer

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The treatment, however, is associated with a decreased risk of all-cause mortality in men at high risk of disease progression.

Exercise Eases Adverse Effects of Androgen-Deprivation Therapy

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It is beneficial in terms of muscle strength, cardiorespiratory fitness, functional task performance, lean body mass, and fatigue.

Prostate Cancer ADT Raises Hip Fracture Risk

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Liberal use of androgen deprivation therapy likely gave prostate cancer patients a fracture risk comparable to that of the cancer itself.

Prostate Cancer ADT Found to Boost Acute Kidney Injury Risk

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Acute kidney injury was most likely to develop in men receiving combined androgen blockade.

Very Low Testosterone Key During Continuous ADT

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Study reveals lower risk of developing castrate-resistant prostate cancer.

Integrated PCa Care Improves IMRT Efficiency

Integrated PCa Care Improves IMRT Efficiency

Integrated prostate cancer centers have greater use of intensity modulated radiation therapy.

PSA Relapse May Be An Unreliable Post-ADT Endpoint

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Testosterone takes a long time to recover, so PSA levels in prostate cancer patients may remain low.

Managing Bone Loss Associated with Androgen Deprivation Therapy

While bone loss and reduction in bone mineral density are well known consequences of ADT, the main concern is increased risk of osteoporotic fractures.

Continuous Superior to Intermittent ADT, Study Finds

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A large, international trial has found intermittent ADT is not equivalent to continuous ADT.

Sildenafil Preserves Erectile Function in Radiotherapy Patients

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Data support prophylactic use of a PDE-5 inhibitor in men receiving radiotherapy for prostate cancer.

Continuous ADT Use for Prostate Cancer Quantified

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Nearly 189,000 men with nonmetastatic disease are receiving continuous ADT for six months or more, researchers estimate.

ADT-Related Fracture Boosts Mortality Risk

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Men with prostate cancer receiving ADT who experience a fracture may have a 1.38-fold higher mortality risk.

Hormonal ADT for Prostate Cancer Ups Heart Attack, Stroke Risk

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Risk is unaffected by orchiectomy, large Danish study finds.

ADT for Prostate Cancer May Raise Biliary Disease Risk

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Elevated risk of gallbladder problems found with use of GnRH agonists.

Exercise Maintains Sexual Interest During Androgen Suppression

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Researchers concluded that exercise be considered as an adjunctive therapy in men undergoing androgen suppression.

Calcium for ADT Bone Loss May Worsen PCa: Interview with Gary Schwartz, PhD

Calcium for ADT Bone Loss May Worsen PCa: Interview with Gary Schwartz, PhD

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Considering that bone loss is a known side effect of ADT for men with PCa, it might seem logical that calcium and vitamin D supplementation would help manage this consequence.

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