Androgen Deprivation

Steps for Reducing CVD Risks in Prostate Cancer Patients

Steps for Reducing CVD Risks in Prostate Cancer Patients

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The advice is useful as clinicians wait for formal guidelines.

Modest Survival Benefit with EBRT + Brachytherapy in Intermediate PCa

Modest Survival Benefit with EBRT + Brachytherapy in Intermediate PCa

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Combined radiotherapy remains controversial due to the increased potential for toxicities.

Adjuvant Bicalutamide With Salvage RT Improves Local PCa Survival

Adjuvant Bicalutamide With Salvage RT Improves Local PCa Survival

Anti-androgen therapy during and after salvage radiotherapy in patients with localized prostate cancer significantly improved long-term overall survival.

Study: ADT, Radiotherapy Possibly Reduce Bladder Cancer Risk

Study: ADT, Radiotherapy Possibly Reduce Bladder Cancer Risk

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The finding of lower bladder cancer incidence in patients receiving pelvic radiation contrasts with previous research.

Bipolar Androgen Therapy Promising for Advanced Hormone-Sensitive PCa

Bipolar Androgen Therapy Promising for Advanced Hormone-Sensitive PCa

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In a small study, high-dose testosterone given intermittently with androgen deprivation therapy lowered PSA levels without serious adverse effects.

Gene Signature May Predict PCa Hormone Treatment Failure

Gene Signature May Predict PCa Hormone Treatment Failure

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A 12-gene androgen deprivation therapy resistance signature may help guide therapeutic decision making after radical prostatectomy.

Adverse Effects Greater for Medical vs. Surgical Castration in PCa

Adverse Effects Greater for Medical vs. Surgical Castration in PCa

Higher risks of several clinically relevant adverse effects compared with surgical castration.

Low Testosterone Before ADT Predicts Poor Prognosis in Metastatic PCa

Low Testosterone Before ADT Predicts Poor Prognosis in Metastatic PCa

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The study found no association with obesity, however, unlike previous studies.

Androgen Deprivation Therapy Linked to Alzheimer's Disease

Androgen Deprivation Therapy Linked to Alzheimer's Disease

A new study by University of Pennsylvania and Stanford researchers highlights a possible link between men who receive androgen deprivation therapy (ADT) and the future onset of Alzheimer's disease.

Prostate Cancer ADT May Increase Thromboembolic Disease Risk

Prostate Cancer ADT May Increase Thromboembolic Disease Risk

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The risk is highest among patients who switch from anti-androgen to GnRH agonist therapy.

Prostate Cancer ADT Strategies Offer Similar Efficacy, QoL

Prostate Cancer ADT Strategies Offer Similar Efficacy, QoL

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The time to PSA progression in men with relapsing or locally advanced PCa was similar with intermittent and continuous androgen deprivation.

Radiation Minus Androgen Deprivation Better for Certain PCa Patients

Radiation Minus Androgen Deprivation Better for Certain PCa Patients

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Compared with combination treatment, radiation therapy alone was linked with 64% and 83% lower odds of early death and death from cardiac causes among patients with co-existing illnesses.

ADT-RT Results in Improved Outcomes for Locally Advanced PCa

ADT-RT Results in Improved Outcomes for Locally Advanced PCa

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This approach is, or should be, the standard of care for locally advanced PCa, some researchers say.

Recent Developments in Prostate Cancer Management

Recent Developments in Prostate Cancer Management

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Additional novel medical therapies to treat prostate cancer and earlier use of the existing medical therapies are the future of prostate cancer management.

Preop ADT Could Potentially Eradicate High-Risk Prostate Tumors

Preop ADT Could Potentially Eradicate High-Risk Prostate Tumors

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No residual tumor was found in 5.4% of men who received androgen deprivation therapy prior to radical surgery for high-risk prostate cancer.

Acupuncture May Ease Hot Flashes from Androgen Deprivation Therapy

Acupuncture May Ease Hot Flashes from Androgen Deprivation Therapy

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Acupuncture's ability to stimulate endorphin production may partly explain the clinical improvements.

ADT Plus Docetaxel Chemo May Increase Survival in Metastatic Prostate Cancer

ADT Plus Docetaxel Chemo May Increase Survival in Metastatic Prostate Cancer

Adding chemotherapy to hormone therapy added 14 months to patients' lives in study.

Androgen Deprivation for Localized Prostate Cancer Ups Cardiac Risks

Androgen Deprivation for Localized Prostate Cancer Ups Cardiac Risks

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Patients with longer life expectancy are most at risk of cardiac morbidity, researchers concluded.

Active Surveillance of Prostate Cancer Increasing in the U.S.

Active Surveillance of Prostate Cancer Increasing in the U.S.

Many men with low-risk disease being spared prostatectomy, radiation, and androgen deprivation treatment.

Prostate Cancer Treatment May Increase Colorectal Cancer Risk

Prostate Cancer Treatment May Increase Colorectal Cancer Risk

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Researchers observed greater incidences of colorectal cancer among patients who underwent bilateral orchiectomy, surgery, and ADT.

Androgen Deprivation Therapy Increases Metabolic Syndrome

Androgen Deprivation Therapy Increases Metabolic Syndrome

Researchers observed increases in components of metabolic syndrome and in the prevalence of full metabolic syndrome among men with prostate cancer treated with ADT.

Androgen Deprivation Therapy Increases Diabetes Risk

Androgen Deprivation Therapy Increases Diabetes Risk

Findings among men treated for localized prostate cancer.

Short-Term Androgen Deprivation Plus Radiation Superior

Short-Term Androgen Deprivation Plus Radiation Superior

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The combination improved oncologic control better than dose-escalated radiotherapy alone in men with intermediate-risk prostate cancer.

ADT Therapy for Prostate Cancer Linked to Impaired Thinking

ADT Therapy for Prostate Cancer Linked to Impaired Thinking

Men with a particular gene mutation affected most, researchers find.

Early ADT for Recurrent Prostate Cancer May Hike Death Risk

Early ADT for Recurrent Prostate Cancer May Hike Death Risk

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This effect appears to occur mainly in men who experience recurrence when they are younger than 65 and in those with low-risk cancer.

Statins May Help Prostate Cancer Patients on ADT

Statins May Help Prostate Cancer Patients on ADT

Prostate cancer remained stable for an average 10 extra months in men taking statins, but more trials are needed to confirm benefits, researchers say.

Monitor Older Men on ADT for Diabetes and CVD

Monitor Older Men on ADT for Diabetes and CVD

Prolonged androgen deprivation treatment ups risk in older men with prostate cancer, especially those with comorbidities.

Time to PCa Metastasis Affects Overall Survival

Time to PCa Metastasis Affects Overall Survival

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Median time to death was shortest in men with metastatic disease at diagnosis.

Androgen Deprivation Therapy Impairs Physical Function

Androgen Deprivation Therapy Impairs Physical Function

Physical side effects seen over first 12 months of androgen deprivation therapy (ADT) persisted or worsened over 3 years of follow-up.

Statins Promising for Cancers

Statins Promising for Cancers

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Studies suggest that these cholesterol-lowering drugs can improve treatment of genitourinary cancers and prevent contrast-induced nephropathy.

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