One-Year Outcomes Not Worse in Obese Kidney Donors

BOSTON—Researchers who examined renal outcomes in obese living kidney donors observed no increased incidence of hypertension, proteinuria, or renal dysfunction compared with non-obese donors at one year after nephrectomy, according to a report presented at the 2012 American Transplant Congress.

Nidhi Aggarwal, MD, and collaborators at the University of Illinois in Chicago studied 516 living kidney donors with a mean age of 36.4 years. The racial makeup of the group was 41% African American, 24% Caucasian, and 35% Hispanic. Of the 516 donors, 119 had normal weight (body mass index [BMI] below 25 kg/m2), 188 were overweight (BMI 25-29.9), 136 were obese (BMI 30-34.9), and 73 were morbidly obese (BMI 35 kg/m2 or greater).

At 12 months after donation, the proportion of patients with hypertension was 7.4%, 10.4%, 5%, and 10% among normal weight, overweight, obese, and morbidly obese individuals, respectively. The proportion of those with proteinuria was 2.3%, 7.8%, 9.8%, and 4.8%, respectively.  The mean estimated glomerular filtration rate at 12 months was 68, 66, 68, and 72 mL/min/1.73 m2, respectively.

The investigators cautioned that long-term follow-up studies of obese donors are needed to determine renal outcomes beyond the first year post-nephrectomy.

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